NMDAR Biomarkers for Diagnosis and Treatment of Traumatic Brain Injury and Other Disorders

Abstract

Provided are methods for detecting various subunits and isoforms of NMDA receptors to help diagnose and differentiate (1) the anatomical location of NMDA receptor over-expression, (2) ischemic conditions in the central and peripheral nervous systems, and (3) the type and cause of chronic pain.

1 )- 11 ) (canceled) 
   
   
       12 ) An isolated peptide comprising SEQ ID 1, SEQ ID 2 or SEQ ID 3, or an analog or fragment thereof. 
   
   
       13 ) The peptide of  claim 12  linked to a diagnostic substrate or indicator reagent. 
   
   
       14 ) The isolated peptide of  claim 12  comprising SEQ ID 1. 
   
   
       15 ) The isolated peptide of  claim 12  comprising SEQ ID 2. 
   
   
       16 ) The isolated peptide of  claim 12  comprising SEQ ID 3. 
   
   
       17 ) An isolated antibody that is specific for a peptide comprising SEQ ID 1, SEQ ID 2, or SEQ ID 3, or an analog or fragment thereof. 
   
   
       18 ) The isolated antibody of  claim 17  linked to a diagnostic substrate or indicator reagent. 
   
   
       19 ) The isolated antibody of  claim 17  wherein said peptide has SEQ ID 1. 
   
   
       20 ) The isolated antibody of  claim 17  wherein said peptide has SEQ ID 2. 
   
   
       21 ) The isolated antibody of  claim 17  wherein said peptide has SEQ ID 3. 
   
   
       22 ) An isolated nucleic acid that encodes for a peptide comprising SEQ ID 1, SEQ ID 2, or SEQ ID 3, or an analog or fragment thereof. 
   
   
       23 )- 29 ) (canceled)