Anhydrous crystal of bata-lactam compound and method for preparation thereof

Abstract

The present invention provides anhydrous crystals of β-lactam compound represented by the formula: The β-lactam compound of the invention is produced by heating an aqueous solution of a salt of the β-lactam compound and adjusting the pH of the aqueous solution to 3 or lower. The β-lactam compound has excellent storage stability.

1 . Anhydrous crystals of a β-lactam compound represented by formula (1): 
     
       
         
         
             
             
         
       
     
   
   
       2 . Anhydrous crystals according to  claim 1 , which have peaks at the following interplanar spacings in the X-ray diffraction spectrum obtained by a copper radiation of λ=1.5418 Å through a monochromator:
 d (interplanar spacings)
 8.413-9.298 
 8.248-9.116 
 7.167-7.922 
 6.357-7.026 
 5.728-6.331 
 5.614-6.205 
 5.311-5.870 
 4.871-5.384 
 4.662-5.153 
 4.518-4.994 
 4.420-4.885 
 4.124-4.558 
 3.971-4.389 
 3.331-3.682 
 3.306-3.653 
 3.119-3.447 
 2.743-3.032 
 2.593-2.866 
   
   
   
       3 . Anhydrous crystals according to  claim 2 , wherein the X-ray diffraction spectrum obtained by a copper radiation through a monochromator, λ=1.5418 Å, is characterized by the following interplanar spacings and relative intensities: 
     
       
         
               
               
               
             
                   
                   
               
                   
                 d (interplanar spacings) 
                 Relative intensities (I/I o ) 
               
                   
                   
               
                   
                 8.413-9.298 
                 0.11-0.31 
               
                   
                 8.248-9.116 
                 0.01-0.40 
               
                   
                 7.167-7.922 
                 0.29-0.43 
               
                   
                 6.357-7.026 
                 0.58-0.76 
               
                   
                 5.728-6.331 
                 0.01-1.00 
               
                   
                 5.614-6.205 
                 0.38-0.98 
               
                   
                 5.311-5.870 
                 0.43-0.65 
               
                   
                 4.871-5.384 
                 0.29-0.57 
               
                   
                 4.662-5.153 
                 0.80-1.00 
               
                   
                 4.518-4.994 
                 0.02-0.40 
               
                   
                 4.420-4.885 
                 0.14-0.22 
               
                   
                 4.124-4.558 
                 0.01-0.55 
               
                   
                 3.971-4.389 
                 0.58-0.82 
               
                   
                 3.331-3.682 
                 0.10-0.50 
               
                   
                 3.306-3.653 
                 0.09-0.37 
               
                   
                 3.119-3.447 
                 0.01-0.56 
               
                   
                 2.743-3.032 
                 0.31-0.57 
               
                   
                 2.593-2.866 
                 0.01-0.75 
               
                   
                   
               
           
              
              
              
             
             
              
              
              
              
              
              
              
              
              
              
              
              
              
              
              
              
              
              
              
             
          
         
       
     
   
   
       4 . (canceled)