US2009263419A1PendingUtilityA1

Live attenuated bacterial vaccine

69
Assignee: GOVERNERS FOR HIGHER EDUCATIONPriority: Aug 29, 2003Filed: May 21, 2009Published: Oct 22, 2009
Est. expiryAug 29, 2023(expired)· nominal 20-yr term from priority
Inventors:Paul S. Cohen
A61K 2039/522A61K 39/02A61P 31/04A61K 39/0275A61P 37/04A61K 2039/523Y02A50/30
69
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Claims

Abstract

A live, attenuated bacterium of the genus Escherichia, Yersinia or Salmonella, that does not have a functional tRNA5leu, and vaccines comprising the live, attenuated bacterium.

Claims

exact text as granted — not AI-modified
1 - 11 . (canceled) 
     
     
         12 . A vaccine comprising an immunogenically effective amount of live, attenuated  Salmonella typhimurium  ( S. typhimurium ), said  S. typhimurium  not having a functional tRNA 5   leu , and a pharmaceutically acceptable carrier. 
     
     
         13 . The vaccine according to  claim 12 , wherein the  S. typhimurium  does not have a functional tRNA 5   leu  as the result of a mutation in the leux gene. 
     
     
         14 . The vaccine according to  claim 13 , wherein the mutation in the leux gene comprises an insertion. 
     
     
         15 . The vaccine according to  claim 14 , wherein the mutation in the leux gene comprises the insertion of a heterologous gene. 
     
     
         16 . The vaccine of  claim 12 , wherein the  S. typhimurium  comprises a heterologous gene. 
     
     
         17 . The vaccine of  claim 13 , wherein the mutation in the leux gene comprises a deletion. 
     
     
         18 . The vaccine of  claim 13 , wherein the mutation in the leux gene comprises a deletion and an insertion. 
     
     
         19 . The vaccine of  claim 13 , wherein the mutation in the leux gene comprises a substitution.

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