Cancer antigen peptide formulations

Abstract

Cancer antigen peptides derived from WT 1 which have an in vivo efficacy, particularly a clinical usefulness, and cancer vaccines as dosage forms suitable for said cancer antigen peptides, are provided. The invention relates to water-in-oil emulsions which comprise as an effective ingredient either one or both of peptides selected from the group consisting of a peptide having an amino acid sequence of Cys Met Thr Trp Asn Gln Met Asn Leu (SEQ ID NO: 2), and a peptide having an amino acid sequence of Cys Tyr Thr Trp Asn Gln Met Asn Leu (SEQ ID NO: 3), as well as processes for preparation of said emulsion.

1 - 7 . (canceled) 
     
     
         8 . A water-in-oil emulsion which comprises as an effective ingredient a peptide having the amino acid sequence of Cys Met Thr Trp Asn Gln Met Asn Leu (SEQ ID NO:2). 
     
     
         9 . The emulsion according to  claim 8 , wherein the emulsion is in a dosage unit form that comprises 0.1 to 100 mg of the peptide. 
     
     
         10 . The emulsion according to  claim 8 , wherein the emulsion is to be used as a cancer vaccine. 
     
     
         11 . The emulsion according to  claim 9 , wherein the emulsion is to be used as a cancer vaccine. 
     
     
         12 . A process for preparation of the water-in-oil emulsion according to  claim 8 , which comprises mixing a preparation comprising a peptide having the amino acid sequence of Cys Met Thr Trp Asn Gln Met Asn Leu (SEQ ID NO:2), together with an emulsifier and an oil. 
     
     
         13 . A kit for preparation of the water-in-oil emulsion according to  claim 8 , which includes a container comprising a peptide having the amino acid sequence of Cys Met Thr Trp Asn Gln Met Asn Leu (SEQ ID NO:2), and a container comprising an emulsifier and an oil. 
     
     
         14 . The kit according to  claim 13 , wherein the kit is to be used to prepare the water-in-oil emulsion according to claim  1  just before use. 
     
     
         15 . A method for treatment of lung cancer in a patient in need thereof who is positive for WTI, which comprises administering a water-in-oil emulsion which comprises as an effective ingredient a peptide having the amino acid sequence of Cys Met Thr Trp Asn Gln Met Asn Leu (SEQ ID NO:2).