US2009258822A1PendingUtilityA1

Diagnosis and Treatment of Age-Related Macular Degeneration

69
Assignee: UNIV IOWA RES FOUNDPriority: Feb 14, 2005Filed: Jun 8, 2009Published: Oct 15, 2009
Est. expiryFeb 14, 2025(expired)· nominal 20-yr term from priority
Inventors:Gregory S. Hageman
A61P 43/00A61P 27/00A61P 27/02C12Q 2600/136C12Q 2600/158C12Q 2600/156A61P 17/00C07K 14/435A61K 9/0048C12Q 2600/172C12Q 1/6883C12Q 1/6827C07K 14/47A61P 13/12A61K 38/1703C12N 15/63A61K 48/00A61K 48/005A61K 48/0058C12N 15/00C07K 14/472A61P 25/00
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Claims

Abstract

The invention relates to Factor H gene polymorphisms and haplotypes associated with an elevated or a reduced risk of AMD. The invention provides methods and reagents for diagnosis and treatment of AMD.

Claims

exact text as granted — not AI-modified
1 . A diagnostic method for determining a subject's propensity to develop age-related macular degeneration (AMD), comprising detecting the presence or absence of a variation at a polymorphic site of a gene encoding a regulator of complement (RCA), wherein the gene encodes Factor H. 
     
     
         2 .- 28 . (canceled) 
     
     
         29 . A method of treating a patient diagnosed with or at risk for developing age-related macular degeneration (AMD) comprising administering a Factor H polypeptide to the patient. 
     
     
         30 .- 46 . (canceled) 
     
     
         47 . An isolated host cell expressing a recombinant variant human Factor H, wherein said variant has histidine in place of tyrosine at amino acid 402 (Y402H), or the variant has cysteine in place of arginine at amino acid 1210 (R120C). 
     
     
         48 .- 60 . (canceled)

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