US2009258092A1PendingUtilityA1

Improved Tissue Maintenance

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Assignee: HIBERNATION THREAPEUTICS LTDPriority: May 29, 2006Filed: May 29, 2006Published: Oct 15, 2009
Est. expiryMay 29, 2026(expired)· nominal 20-yr term from priority
Inventors:Geoffrey Philip Dobson
A61K 31/7076A61K 31/167A61P 9/00A61P 9/10A61K 33/06A61P 41/00A61K 45/06A01N 1/126A01N 1/10
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Claims

Abstract

The invention provides a method of reducing damage to a tissue, organ or cell from surgical procedures comprising administering a composition comprising a potassium channel opener/agonist and/or an adenosine receptor agonist (eg. adenosine) together with a local anaesthetic (eg. lignocaine) when perfusing the organ.

Claims

exact text as granted — not AI-modified
1 . A method of reducing damage to a tissue, organ or cell from periods of reduced activity comprising administering a composition comprising:
 a potassium channel opener/agonist and/or an adenosine receptor agonist, together with   a local anaesthetic.   
   
   
       2 . A method according to  claim 1  in which the composition further includes magnesium cations. 
   
   
       3 . A method according to  claim 1  in which the composition is heated to at least 32° C. before administration. 
   
   
       4 . A method according to  claim 1  wherein the composition is administered when reperfusing the organ. 
   
   
       5 . A method according to  claim 1  wherein the reduced activity is medically induced. 
   
   
       6 . A method according to  claim 1  wherein the composition is administered while perfusing the organ during a quiescent state. 
   
   
       7 . A method according to  claim 1  wherein the organ is a heart and the reduced activity is cardioplegic arrest. 
   
   
       8 . A method of reducing post-operative fibrillation following a heart procedure comprising administering a composition comprising:
 a potassium channel opener/agonist and/or an adenosine receptor agonist, together with   a local anaesthetic.   
   
   
       9 . A method according to  claim 8  wherein the composition is administered during the recovery phase of the procedure. 
   
   
       10 . A composition for reducing the risk or incidence of post-operative complications from surgical procedures comprising a potassium channel opener/agonist and/or an adenosine receptor agonist together with a local anaesthetic and magnesium cations. 
   
   
       11 . A composition according to  claim 10  having a potassium concentration of less than about 10 mM.

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