Pharmaceutical composition for treating depression and method for preparation thereof

Abstract

A pharmaceutical composition for treating depression and method for preparation thereof is provided. The pharmaceutical composition includes Radix Ginseng, Radix Glycyrrhizae, and/or their aqueous or alcoholic extract. Fructus Jujubae or their aqueous or alcoholic extract can also be included in the pharmaceutical composition.

1 . A pharmaceutical composition for treating a depression, at least comprising one of the following compositions of raw materials:
 (A) 4˜18 parts by weight of a ginseng and 3˜14 parts by weight of a liquorice;   (B) a ginseng extract extracted from 4˜18 parts by weight of the ginseng and a liquorice extract extracted from 3˜14 parts by weight of the liquorice;   (C) 4˜18 parts by weight of the ginseng and the liquorice extract extracted from 3˜14 parts by weight of the liquorice; and   (D) a ginseng extract extracted from 4˜18 parts by weight of the ginseng and 3˜14 parts by weight of the liquorice.   
   
   
       2 . The pharmaceutical composition according to  claim 1 , further comprising one of 3˜14 parts by weight of a jujuba and a jujuba extract extracted from 3˜14 parts by weight of the jujuba, wherein the jujuba extract is one of a jujuba water extract and a jujuba ethanol extract. 
   
   
       3 . The pharmaceutical composition according to  claim 1 , further comprising one of 4˜8 parts by weight of a jujuba and a jujuba extract extracted from 4˜8 parts by weight of the jujuba. 
   
   
       4 . The pharmaceutical composition according to  claim 1 , wherein the composition (A) of the raw materials is formed by 7˜11 parts by weight of the ginseng and 4˜8 parts by weight of the liquorice. 
   
   
       5 . The pharmaceutical composition according to  claim 1 , wherein the ginseng extract of the composition (B) of the raw materials is extracted from 7˜11 parts by weight of the ginseng and the liquorice extract thereof is extracted from 4˜8 parts by weight of the liquorice. 
   
   
       6 . The pharmaceutical composition according to  claim 1 , wherein the pharmaceutical composition comprises a pharmacologically acceptable additive. 
   
   
       7 . The pharmaceutical composition according to  claim 1 , wherein the pharmaceutical composition is processed into one selected from a group of a powder, a capsule, a tablet, and a pill. 
   
   
       8 . The pharmaceutical composition according to  claim 1 , wherein the ginseng extract is one of a ginseng water extract and a ginseng ethanol extract, and the liquorice extract is one of a liquorice water extract and a liquorice ethanol extract. 
   
   
       9 . A pharmaceutical composition for treating a depression, comprising:
 a ginseng extract extracted from 3A˜10A parts by weight of a ginseng and having B % content of a ginsenoside, wherein a multiplication product of B and A is 20˜40, and A is ranged between 0.2 and 40; and   0.2C˜0.8C part by weight of a glycyrrhizically related acid having D % purity, wherein a multiplication product of D and C is 80˜98, and C is ranged between 0.8 and 98.   
   
   
       10 . The pharmaceutical composition according to  claim 9 , wherein the ginseng is one of a ginseng water extract and a ginseng ethanol extract, and the glycyrrhizically related acid is one of a glycyrrhizic acid and a glycyrrhetic acid. 
   
   
       11 . The pharmaceutical composition according to  claim 10 , wherein the ginseng ethanol extract comprises 20˜40% content of the ginsenoside, and the purity of the glycyrrhizically related acid is 80˜98%. 
   
   
       12 . The pharmaceutical composition according to  claim 9 , further comprising a jujuba extract extracted from 0.05E˜0.2E part by weight of ajujuba and having F % content of a jujuba cyclic adenosine monophosphate (cAMP), wherein a multiplication product of F and E is 0.5˜3, E is ranged between 0.005 and 3, and the jujuba extract is one of a jujuba water extract and a jujuba ethanol extract. 
   
   
       13 . The pharmaceutical composition according to  claim 12 , wherein the jujuba ethanol extract comprises 0.5˜3% content of the jujuba cAMP. 
   
   
       14 . The pharmaceutical composition according to  claim 9 , wherein the ginseng extract is an ethanol extract extracted from 4˜6 parts by weight of the ginseng and has 25˜35% content of ginsenoside, the glycyrrhizically related acid is 0.3˜0.5 part by weight of a glycyrrhetic acid having 85˜95% purity, and the pharmaceutical composition further comprises a jujuba ethanol extract extracted from 0.08˜0.12 part by weight of a jujuba and having 0.8˜1.2% purity of a jujuba cAMP. 
   
   
       15 . The pharmaceutical composition according to  claim 9 , wherein the pharmaceutical composition comprises a pharmacologically acceptable additive. 
   
   
       16 . The pharmaceutical composition according to  claim 9 , wherein the pharmaceutical composition is processed into one selected from a group consisting of a powder, a capsule, a tablet, and a pill. 
   
   
       17 . A preparation method of a pharmaceutical composition, comprising steps of:
 (1) decocting 4˜18 parts by weight of a ginseng in 60˜77% concentration of an ethanol solution to obtain a first extract;   (2) decocting 4˜18 parts by weight of a liquorice in a water to obtain a second extract; and   (3) mixing and sifting the first extract and the second extract to obtain the pharmaceutical composition.   
   
   
       18 . The preparation method according to  claim 17 , further comprising a step of:
 (4) extracting 3˜14 parts by weight of a jujuba in 60˜75% concentration of the ethanol solution to obtain a third extract, and adding the third extract into the pharmaceutical composition.   
   
   
       19 . A preparation method of a pharmaceutical composition, comprising a step of:
 (1) mixing 3˜10 parts by weight of a ginseng extract having 20˜40% content of a ginsenoside with 0.2˜0.8 part by weight of a glycyrrhizically related acid having 80˜98% purity to obtain a pharmaceutical composition.   
   
   
       20 . The preparation method according to  claim 17 , further comprising a step of:
 (2) compounding a β-cyclodextrin with a jujuba extract extracted from 0.05˜0.2 part by weight of a jujuba and having 1% jujuba cyclic adenosine monophosphate (cAMP) to obtain a jujuba extract compound, and adding the jujuba extract compound into the pharmaceutical composition.