Lubricious coatings for medical devices

Abstract

An ultraviolet curable lubricious coating including at least one lubricious polymer and at least one oxygen-insensitive crosslinkable polymer, methods of making and using the same, and articles coated therewith.

1 . An ultraviolet curable lubricious coating comprising:
 a) at least one lubricious polymer; and   b) at least one polymer which is crosslinkable by an oxygen-insensitive non-cationic mechanism.   
   
   
       2 . The lubricious coating of  claim 1  wherein said at least one lubricious polymer is hydrophobic, hydrophilic or a mixture thereof. 
   
   
       3 . (canceled) 
   
   
       4 . The lubricious coating of  claim 1  wherein said at least one lubricious polymer is a noncrosslinked hydrogel. 
   
   
       5 . The lubricious coating of  claim 1  wherein said at least one lubricious polymer is crosslinkable. 
   
   
       6 . The lubricious coating of  claim 5  wherein said lubricious polymer and said at least one oxygen-insensitive crosslinkable polymer form an interpenetrating network. 
   
   
       7 . The lubricious coating of  claim 1  wherein said crosslinkable polymer comprises at least one styrylpyridinium group. 
   
   
       8 . The lubricious coating of  claim 1  wherein said crosslinkable polymer has the following general structure: 
     
       
         
         
             
             
         
       
       where m and n are positive numbers and X is an anion. 
     
   
   
       9 . The lubricious coating of  claim 1  wherein said lubricious polymer is a hydrophilic polymer selected from the group consisting of poly(acrylic acid), poly(methacrylic acid), polyurethanes, polyethylene oxide, poly(N-isopolyacrylamide), or polymers of hydroxyl-substituted lower alkyl acrylates, methacrylates, acrylamide, methacrylamide, lower allylacrylamides and methacrylamides, hydroxyl-substituted lower alkyl vinyl ethers, sodium vinylsulfonate, sodium styrenesulfonate, 2-acrylamido-2-methylpropanesulfonic acid, N-vinylpyrrole, N-vinyl-2-pyrrolidone, 2-vinyloxazoline, 2-vinyl4,4′-dialkyloxazolin-5-one, 2- and 4-inylpruidine, vinylically unsaturated carboxylic acids having a total of 3 to 5 carbon atoms, amino-lower alkyl (where the term ‘amino” also includes quaternary ammonium), mono-lower alkylamino-lower alkyl and di-lower alkylamino-lower alkyl acrylates and methacrylates, allyl alcohol, any copolymers thereof, and mixtures thereof. 
   
   
       10 . The lubricious coating of  claim 9  wherein said lubricious polymer is polyethylene oxide. 
   
   
       11 . The lubricious coating of  claim 9  wherein said lubricious polymer is a polyurethane or a blend of polyurethanes. 
   
   
       12 . A medical device comprising:
 a) a tubular member;   b) a coating on said tubular member, said coating comprising at least one hydrophilic polymer and at least one polymer which is crosslinkable by an oxygen-insensitive, non-cationic mechanism.   
   
   
       13 . The medical device of  claim 12  wherein said oxygen-insensitive crosslinkable polymer comprises styrylpyridinium groups. 
   
   
       14 . The medical device of  claim 12  wherein said oxygen-insensitive crosslinkable polymer has the following general structure: 
     
       
         
         
             
             
         
       
       where m and n are positive numbers and X is an anion. 
     
   
   
       15 . The medical device of  claim 12  wherein said at least one hydrophilic polymer comprises at least one member selected from the group consisting of poly(acrylic acid), poly(methacrylic acid), polyurethanes, polyethylene oxide, poly(N-isopolyacrylamide), or polymers of hydroxyl-substituted lower alkyl acrylates, methacrylates, acrylamide, methacrylamide, lower allylacrylamides and methacrylamides, hydroxyl-substituted lower alkyl vinyl ethers, sodium vinylsulfonate, sodium styrenesulfonate, 2-acrylamido-2-methylpropanesulfonic acid, N-vinylpyrrole, N-vinyl-2-pyrrolidone, 2-vinyloxazoline, 2-vinyl4,4′-dialkyloxazolin-5-one, 2- and 4-inylpruidine, vinylically unsaturated carboxylic acids having a total of 3 to 5 carbon atoms, amino-lower alkyl (where the term ‘amino” also includes quaternary ammonium), mono-lower alkylamino-lower alkyl and di-lower alkylamino-lower alkyl acrylates and methacrylates, allyl alcohol and mixtures thereof. 
   
   
       16 . The medical device of  claim 15  wherein said at least one hydrophilic polymer is polyethylene oxide. 
   
   
       17 . The medical device of  claim 15  wherein said at least one hydrophilic polymer is a polyurethane or a blend of polyurethanes. 
   
   
       18 . The medical device of  claim 17  wherein said at least one hydrophilic polymer is an aliphatic polyether polyurethane. 
   
   
       19 . The medical device of  claim 18  wherein said at least one aliphatic polyether polyurethane can absorb from about 500% to about 2000% water by weight. 
   
   
       20 . The medical device of  claim 12  wherein said tubular member has an inner surface and an outer surface, said hydrophilic coating is on said inner surface said outer surface or a combination thereof. 
   
   
       21 . (canceled) 
   
   
       22 . A dilatation balloon with a coating, said coating comprising at least one lubricious polymer and at least one polymer which is crosslinkable by an oxygen-insensitive non-cationic mechanism. 
   
   
       23 - 43 . (canceled)