US2009227005A1PendingUtilityA1

Methods for pathogen detection

56
Assignee: SEARETE LLCPriority: Mar 27, 2007Filed: Sep 28, 2007Published: Sep 10, 2009
Est. expiryMar 27, 2027(~0.7 yrs left)· nominal 20-yr term from priority
Inventors:Edward K.Y. JungEric C. LeuthardtRoyce A. LevienRobert W. LordMark A. MalamudJohn D. Rinaldo, Jr.Lowell L. Wood, Jr.
G01N 35/00G01N 2035/00158B01L 3/502761
56
PatentIndex Score
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Cited by
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Claims

Abstract

The present disclosure relates to methods, systems, devices, and microfluidic chips that may be used for the detection of pathogens.

Claims

exact text as granted — not AI-modified
1 .- 78 . (canceled) 
   
   
       79 . A system comprising:
 circuitry for combining one or more samples with one or more magnetically active pathogen indicator binding agents that can bind to one or more pathogen indicators associated with the one or more samples to form one or more magnetically active pathogen indicator complexes; and   circuitry for separating the one or more magnetically active pathogen indicator complexes from the one or more samples through use of one or more magnetic fields and one or more separation fluids that are in substantially parallel flow with the one or more samples.   
   
   
       80 . The system of  claim 79 , wherein the circuitry for combining one or more samples with one or more magnetically active pathogen indicator binding agents that can bind to one or more pathogen indicators associated with the one or more samples to form one or more magnetically active pathogen indicator complexes comprises:
 circuitry for combining the one or more samples with at least one magnetically active antibody, aptamer, polynucleotide, or polypeptide.   
   
   
       81 . The system of  claim 79 , wherein the circuitry for separating the one or more magnetically active pathogen indicator complexes from the one or more samples through use of one or more magnetic fields and one or more separation fluids that are in substantially parallel flow with the one or more samples comprises:
 circuitry for separating the one or more magnetically active pathogen indicator complexes through use of magnetic attraction or magnetic repulsion.   
   
   
       82 . The system of  claim 79 , wherein the circuitry for separating the one or more magnetically active pathogen indicator complexes from the one or more samples through use of one or more magnetic fields and one or more separation fluids that are in substantially parallel flow with the one or more samples comprises:
 circuitry for separating the one or more magnetically active pathogen indicator complexes through use of one or more ferrofluids.   
   
   
       83 . The system of  claim 79 , further comprising:
 circuitry for analyzing the one or more samples.   
   
   
       84 . (canceled) 
   
   
       85 . The system of  claim 83 , further comprising:
 circuitry for identifying one or more pathogens present within the one or more samples.   
   
   
       86 . (canceled) 
   
   
       87 . The system of  claim 85 , wherein the circuitry for identifying one or more pathogens present within the one or more samples comprises:
 circuitry for displaying an identity of the one or more pathogens present within the one or more samples.   
   
   
       88 . A system comprising:
 circuitry for combining one or more samples with one or more magnetically active pathogen indicator binding agents that can bind to one or more pathogen indicators associated with the one or more samples to form one or more magnetically active pathogen indicator complexes; and   circuitry for separating the one or more magnetically active pathogen indicator complexes from the one or more samples through use of one or more magnetic fields and one or more separation fluids that are in substantially antiparallel flow with the one or more samples.   
   
   
       89 . The system of  claim 88 , wherein the circuitry for combining one or more samples with one or more magnetically active pathogen indicator binding agents that can bind to one or more pathogen indicators associated with the one or more samples to form one or more magnetically active pathogen indicator complexes comprises:
 circuitry for combining the one or more samples with at least one magnetically active antibody, aptamer, polynucleotide, or polypeptide.   
   
   
       90 . The system of  claim 88 , wherein the circuitry for separating the one or more magnetically active pathogen indicator complexes from the one or more samples through use of one or more magnetic fields and one or more separation fluids that are in substantially antiparallel flow with the one or more samples comprises:
 circuitry for separating the one or more magnetically active pathogen indicator complexes through use of magnetic attraction or magnetic repulsion.   
   
   
       91 . The system of  claim 88 , wherein the circuitry for separating the one or more magnetically active pathogen indicator complexes from the one or more samples through use of one or more magnetic fields and one or more separation fluids that are in substantially antiparallel flow with the one or more samples comprises:
 circuitry for separating the one or more magnetically active pathogen indicator complexes through use of one or more ferrofluids.   
   
   
       92 . The system of  claim 88 . further comprising:
 circuitry for analyzing the one or more samples.   
   
   
       93 . (canceled) 
   
   
       94 . The system of  claim 92 , further comprising:
 circuitry for identifying one or more pathogens present within the one or more samples.   
   
   
       95 . (canceled) 
   
   
       96 . The system of  claim 94 , wherein the circuitry for identifying one or more pathogens present within the one or more samples comprises:
 circuitry for displaying an identity of the one or more pathogens present within the one or more samples.   
   
   
       97 .- 122 . (canceled) 
   
   
       123 . A system comprising:
 circuitry for separating one or more magnetically active pathogen indicator complexes from one or more samples through use of one or more magnetic fields and one or more separation fluids that are in substantially parallel flow with the one or more samples.   
   
   
       124 . The system of  claim 123 , wherein the circuitry for separating one or more magnetically active pathogen indicator complexes from one or more samples through use of one or more magnetic fields and one or more separation fluids that are in substantially parallel flow with the one or more samples comprises:
 circuitry for separating the one or more magnetically active pathogen indicator complexes through use of magnetic attraction or magnetic repulsion.   
   
   
       125 . The system of  claim 123 , wherein the circuitry for separating one or more magnetically active pathogen indicator complexes from one or more samples through use of one or more magnetic fields and one or more separation fluids that are in substantially parallel flow with the one or more samples comprises:
 circuitry for separating the one or more magnetically active pathogen indicator complexes through use of one or more ferrofluids.   
   
   
       126 . The system of  claim 123 , further comprising:
 circuitry for detecting one or more pathogen indicators.   
   
   
       127 . (canceled) 
   
   
       128 . The system of  claim 126 , further comprising:
 circuitry for identifying one or more pathogens present within the one or more samples.   
   
   
       129 . (canceled) 
   
   
       130 . The system of  claim 128 , wherein the circuitry for identifying one or more pathogens present within the one or more samples comprises:
 circuitry for displaying an identity of the one or more pathogens present within the one or more samples.   
   
   
       131 . A system comprising:
 circuitry for separating one or more magnetically active pathogen indicator complexes from one or more samples through use of one or more magnetic fields and one or more separation fluids that are in substantially antiparallel flow with the one or more samples.   
   
   
       132 . The system of claim  13 l wherein the circuitry for separating one or more magnetically active pathogen indicator complexes from one or more samples through use of one or more magnetic fields and one or more separation fluids that are in substantially antiparallel flow with the one or more samples comprises:
 circuitry for separating the one or more magnetically active pathogen indicator complexes through use of magnetic attraction or magnetic repulsion.   
   
   
       133 . The system of  claim 131 , wherein the circuitry for separating one or more magnetically active pathogen indicator complexes from one or more samples through use of one or more magnetic fields and one or more separation fluids that are in substantially antiparallel flow with the one or more samples comprises:
 circuitry for separating the one or more magnetically active pathogen indicator complexes through use of one or more ferrofluids.   
   
   
       134 . The system of  claim 131 , further comprising:
 circuitry for detecting one or more pathogen indicators.   
   
   
       135 . (canceled) 
   
   
       136 . The system of  claim 134 , further comprising:
 circuitry for identifying one or more pathogens present within the one or more samples.   
   
   
       137 . (canceled) 
   
   
       138 . The system of  claim 136 , wherein the circuitry for identifying one or more pathogens present within the one or more samples comprises:
 circuitry for displaying an identity of the one or more pathogens present within the one or more samples.   
   
   
       139 .- 192 . (canceled)

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