US2009216118A1PendingUtilityA1

Polysaccharide markers

62
Assignee: SENORX INCPriority: Jul 26, 2007Filed: Feb 21, 2008Published: Aug 27, 2009
Est. expiryJul 26, 2027(~1 yrs left)· nominal 20-yr term from priority
Inventors:Michael L. JonesPaul Lubock
A61P 7/04A61B 2090/3908A61B 2090/3962A61B 2017/00831A61B 2017/00004A61K 9/0024A61B 2017/00898A61B 90/39A61B 2090/3925A61B 2090/3987
62
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Claims

Abstract

The marker member delivery system described has a plurality of marker members disposed within a delivery tube or cannula which contain a suitable polysaccharide such as starch (e.g. corn starch or potato starch) and a binder such as methylcellulose. These marker members are preferably press-formed from powders. The system has preferably has at least one other marker member formed of bioabsorbable material with a radiopaque element attached to or incorporated therein. The marker with a radiopaque marker element is preferably disposed within the delivery tube between two marker members formed of polysaccharide and is preferably formed of a bioabsorbable material other than a polysaccharide.

Claims

exact text as granted — not AI-modified
1 . A remotely imageable marker system comprising a tubular delivery member and a plurality of marker members which comprise a bioabsorbable polysaccharide in sufficient amounts to exhibit hemostatic properties and a binder and which are disposed within an inner lumen of the tubular delivery member. 
   
   
       2 . The imageable marker system of  claim 1  wherein the marker members are about 10 to about 90% (by wt.) bioabsorbable polysaccharide. 
   
   
       3 . The imageable marker system of  claim 2  wherein the marker members are formed of a polysaccharide selected from the group consisting of starch, glycogen, cellulose, chitin, chitosan, dextran, pectins, glucans, agar, alginate and carrageen. 
   
   
       4 . The imageable marker system of  claim 2  wherein the marker members are formed of corn starch or potato starch. 
   
   
       5 . The imageable marker system of  claim 3  wherein the marker members are about 10 to about 90% (by wt.) binder. 
   
   
       6 . The imageable marker system of  claim 1  wherein the marker members are formed of a binder selected from the group consisting of methycellulose, hydroxyethyl cellulose, polyethylene glycol, polyvinyl alcohol, polyvinylpyrolidone. 
   
   
       7 . The imageable marker system of  claim 1  wherein the marker members are formed of a binder comprising methycellulose. 
   
   
       8 . The imageable marker system of  claim 1  wherein the marker members are press-formed into a desired shape. 
   
   
       9 . The imageable marker system of  claim 8  wherein the press-formed marker members are formed of a powder having particle size less than 0.01 inch. 
   
   
       10 . The imageable marker system of  claim 9  wherein the powder has a particle size of about 10 to about 200 micrometers. 
   
   
       11 . The imageable marker system of  claim 8  wherein the press-formed marker member have a transverse dimension of about 0.02 to about 0.1 inch. 
   
   
       12 . The imageable marker system of  claim 8  wherein the press-formed marker member have a short transverse dimension of about 0.035 to about 0.075 inch. 
   
   
       13 . The imageable marker system of  claim 8  wherein the press-formed marker member has a length of about 0.1 to about 0.4 inch. 
   
   
       14 . The imageable marker system of  claim 8  wherein the press-formed marker member has a length of about 0.15 to about 0.35 inch. 
   
   
       15 . The imageable marker system of  claim 1  wherein the tubular delivery member has a marker body formed of bioabsorbable material and having a radiopaque marker element disposed within the inner lumen thereof. 
   
   
       16 . The imageable marker system of  claim 15  wherein the marker body having a radiopaque marker element is disposed between two marker members formed of polysaccharide. 
   
   
       17 . The imageable marker system of  claim 16  wherein there are two marker members formed of polysaccharide distal to the marker body having a radiopaque marker element. 
   
   
       18 . The imageable marker system of  claim 16  wherein there are two marker members formed of polysaccharide proximal to the marker body having a radiopaque marker element. 
   
   
       19 . An intracorporeal marker comprising a press-formed body of polysaccharide in sufficient amounts to exhibit hemostatic properties and a binder. 
   
   
       20 . The intracorporeal marker of  claim 19  wherein the press-formed body contains about 10 to about 90% (by wt.) bioabsorbable polysaccharide. 
   
   
       21 . The imageable marker of  claim 19  wherein the press-formed body is formed of a polysaccharide selected from the group consisting of starch, glycogen, cellulose, chitin, chitosan, dextran, pectins, glucans, agar, alginate and carrageen. 
   
   
       22 . The imageable marker of  claim 19  wherein the press-formed body is formed of corn starch or potato starch. 
   
   
       23 . The intracorporeal marker of  claim 19  wherein the press-formed body contains about 10 to about 90% (by wt.) binder. 
   
   
       24 . The intracorporeal marker of  claim 19  wherein the press-formed body is formed of a binder selected from the group consisting of methycellulose, hydroxyethyl cellulose, polyethylene glycol, polyvinyl alcohol, polyvinylpyrolidone. 
   
   
       25 . The intracorporeal marker system of  claim 19  wherein the press-formed body is formed of a binder comprising methycellulose. 
   
   
       26 . The intracorporeal marker of  claim 19  wherein the press-formed body is formed of a mixed powder of polysaccharide and binder. 
   
   
       27 . The intracorporeal marker of  claim 26  wherein the powder has a particle size less than 0.01 inch. 
   
   
       28 . The intracorporeal marker of  claim 26  wherein the powder has a particle size of about 10 to about 200 micrometers. 
   
   
       29 . The intracorporeal marker of  claim 19  wherein the press-formed body has a transverse dimension of about 0.02 to about 0.1 inch. 
   
   
       30 . The intracorporeal marker of  claim 19  wherein the press-formed body has a transverse dimension of about 0.035 to about 0.075 inch. 
   
   
       31 . The intracorporeal marker of  claim 19  wherein the press-formed body has a length of about 0.1 to about 0.4 inch. 
   
   
       32 . The intracorporeal marker of  claim 19  wherein the press-formed body has a length of about 0.15 to about 0.35 inch.

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