Administration of pyridinedicarboxylic acid compounds for stimulating or inducing the growth of human keratinous fibers and/or arresting their loss

Abstract

The invention relates to the use in a composition for caring for human hair or eyelashes of an effective amount of a pyridinedicarboxylic acid derivative of general formula (I) or of one of its salts, in which R 1 and R 2 represent, independently of one another, OH, OR′, —NH 2 , —NHR′ or —NR′R″, and R′ and R″ represent, independently of one another, a saturated or unsaturated and linear or branched C 1 -C 18 alkyl radical or an aryl radical, this alkyl or aryl radical optionally being substituted by at least one OH, alkoxy, acyloxy, amino or alkylamino group, or R′ and R″ together represent a heterocycle, the composition being intended to induce and/or stimulate the growth of human keratinous fibers, such as the hair and eyelashes, and/or slow down their loss; the invention also relates to a cosmetic treatment intended to stimulate the growth of human keratinous fibers, such as the hair and eyelashes, and/or slow down their loss.

1 .- 24 . (canceled) 
   
   
       25 . A regime or regimen for inducing/stimulating the growth of human keratinous fibers and/or retarding the loss and/or increasing the density thereof, comprising administering to an individual subject in need of such treatment, a thus effective amount of at least one compound having the following structural formula (I), or salt selected from the group consisting of the double salt of sodium or of potassium, zinc (Zn 2+ ), calcium (Ca 2+ ), copper (Cu 2+ ), iron (Fe 2+ ), strontium (Sr 2+ ), magnesium (Mg 2+ ) and manganese (Mn 2+ ) salts, triethanolamine, monoethanolamine, diethanolamine, hexadecylamine, N,N,N′,N′-tetrakis(2-hydroxypropyl)-ethylenediamine or tris(hydroxymethyl)aminomethane salts, hydroxides, carbonates and chlorides: 
     
       
         
         
             
             
         
       
       in which:
 R 1  and R 2 , which may be identical or different, are each OH, OR′, wherein R′ represents a saturated or unsaturated linear or branched C 1 -C 18  alkyl radical. 
 
     
   
   
       26 . The regime or regimen as defined by  claim 25 , for inducing/stimulating the growth of human head hair, eyebrows, eyelashes, beard hairs, moustache hairs or pubic hairs and/or retarding the loss and/or increasing the density thereof. 
   
   
       27 . A regime or regimen for inducing/stimulating the growth of human head hair and/or retarding the loss and/or increasing the density thereof, comprising topically applying onto the hair and/or scalp of an individual in need of such treatment, a thus effective amount of at least one compound having the following structural formula (I), or salt thereof: 
     
       
         
         
             
             
         
       
       in which:
 R 1  and R 2 , which may be identical or different, are each OH, OR′, wherein R′ represents a saturated or unsaturated linear or branched C 1 -C 18  alkyl radical. 
 
     
   
   
       28 . A regime or regimen for treating androgenic alopecia, comprising administering to an individual in need of such treatment, a thus effective amount of at least one compound having the following structural formula (I), or salt thereof: 
     
       
         
         
             
             
         
       
       in which:
 R 1  and R 2 , which may be identical or different, are each OH, OR′, wherein R′ represents a saturated or unsaturated linear or branched C 1 -C 18  alkyl radical. 
 
     
   
   
       29 . The regime or regimen as defined by  claim 25 , wherein formula (I), R 1  and R 2 , which may be identical or different, are each: 
     
       
         
         
             
             
         
       
     
   
   
       30 . The regime or regimen as defined by  claim 25 , wherein formula (I), R 1  and R 2 , are respectively in the 2 and 3 or 2 and 4 positions of the pyridine ring. 
   
   
       31 . The regime or regimen as defined by  claim 25 , comprising administering a salt of said at least one compound of formula (I), selected from the group consisting of the double salt of sodium or of potassium, calcium (Ca 2+ ), copper (Cu 2+ ), iron (Fe 2+ ), strontium (Sr 2+ ), magnesium (Mg 2+ ) and manganese (Mn 2+ ) salts, triethanolamine, monoethanolamine, diethanolamine, hexadecylamine, N,N,N′,N′-tetrakis(2-hydroxypropyl)-ethylenediamine or tris(hydroxymethyl)aminomethane salts, hydroxides, carbonates and chlorides. 
   
   
       32 . The regime or regimen as defined by  claim 25 , comprising administering a thus effective amount of: 
     pyridine-2,4-dicarboxylic acid or its sodium salt, 
     pyridine-2,3-dicarboxylic acid or its sodium salt, 
     dimethylpyridine-2,4-dicarboxylate, 
     dimethylpyridine-2,3-dicarboxylate, 
     diethyl pyridine-2,4-dicarboxylate, 
     diethyl pyridine-2,3-dicarboxylate, 
     diisopropyl pyridine-2,4-dicarboxylate, 
     2,4-di(n-propylamido) pyridine, 
     diethyl pyridine-2,5-dicarboxylate, 
     dimethylpyridine-2,5-dicarboxylate, 
     2,4-di(2-hydroxyethylamido)pyridine, 
     2,4-di(3-hydroxypropylamido)pyridine, or mixture thereof. 
   
   
       33 . The regime or regimen as defined by  claim 25 , said at least one compound of formula (I) comprising an ester. 
   
   
       34 . The regime or regimen as defined by  claim 32 , comprising administering a thus effective amount of diethyl pyridine-2,4-dicarboxylate. 
   
   
       35 . A regime or regimen for inducing/stimulating the growth of human keratinous fibers and/or retarding the loss and/or increasing the density thereof, comprising administering to an individual in need of such treatment, a thus effective amount of at least one compound having the structural formula (I): 
     
       
         
         
             
             
         
       
       in which:
 R 1  and R 2  are respectively in the 2 and 4 positions of the pyridine ring and wherein R 1  and R 2 , which may be identical or different, are each OH, OR 1 , wherein R 1  represents a saturated linear or branched C 1 -C 10  alky radical. 
 
     
   
   
       36 . The regime or regimen of  claim 35 , wherein R 1  and R 2  are each: 
     
       
         
         
             
             
         
       
     
   
   
       37 . The regime or regimen of  claim 35 , wherein the compound of formula (I) is selected from the group consisting of pyridine-2,4-dicarboxylic acid or its sodium salt, dimethylpyridine-2,4-dicarboxylate, diethyl pyridine-2,4-dicarboxylate, diisopropyl pyridine-2,4-dicarboxylate, or a mixture thereof. 
   
   
       38 . A regime or regimen for inducing/stimulating the growth of human head hair and/or retarding the loss and/or increasing the density thereof, comprising topically applying onto the hair and/or scalp of an individual in need of such treatment, a thus effective amount of at least one compound having the structural formula (I): 
     
       
         
         
             
             
         
       
       in which:
 R 1  and R 2  are respectively in the 2 and 4 positions of the pyridine ring and wherein R 1  and R 2  which may be identical or different, are each OH, OR 1 , wherein R 1  represents a saturated linear or branched C 1 -C 10  alky radical. 
 
     
   
   
       39 . The regime or regimen of  claim 38 , wherein R 1  and R 2  are each: 
     
       
         
         
             
             
         
       
     
   
   
       40 . The regime or regimen of  claim 38 , wherein the compound of formula (I) is selected from the group consisting of pyridine-2,4-dicarboxylic acid or its sodium salt, dimethylpyridine-2,4-dicarboxylate, diethyl pyridine-2,4-dicarboxylate, diisopropyl pyridine-2,4-dicarboxylate, or a mixture thereof. 
   
   
       41 . A regime or regimen for treating androgenic alopecia, comprising administering to an individual in need of such treatment, a thus effective amount of at least one compound having the structural formula (I): 
     
       
         
         
             
             
         
       
       in which:
 R 1  and R 2  are respectively in the 2 and 4 positions of the pyridine ring and wherein R 1  and R 2  which may be identical or different, are each OH, OR 1 , wherein R 1  represents a saturated linear or branched C 1 -C 10  alky radical. 
 
     
   
   
       42 . The regime or regimen of  claim 41 , wherein R 1  and R 2  are each: 
     
       
         
         
             
             
         
       
     
   
   
       43 . The regime or regimen of  claim 41 , wherein the compound of formula (I) is selected from the group consisting of pyridine-2,4-dicarboxylic acid or its sodium salt, dimethylpyridine-2,4-dicarboxylate, diethyl pyridine-2,4-dicarboxylate, diisopropyl pyridine-2,4-dicarboxylate, or a mixture thereof.