Polynucleotides and Polypeptides Encoding Receptors

Abstract

Receptor polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing receptor polypeptides and polynucleotides in the design of protocols for the treatment of diseases and diagnostic assays for such conditions.

1 . An isolated polynucleotide comprising a nucleotide sequence that has at least 80% identity over its entire length to a nucleotide sequence selected from the group consisting of:
 (a) a nucleotide sequence encoding the polypeptide of SEQ ID NO:Y;   (b) a nucleotide sequence having at least 80% identity to a nucleotide sequence encoding the polypeptide expressed by the cDNA insert deposited at the ATCC; or   (c) a nucleotide sequence complementary to said isolated polynucleotide.   
     
     
         2 . The polynucleotide of  claim 1 , wherein said polynucleotide is (a). 
     
     
         3 . The polynucleotide of  claim 1 , wherein said polynucleotide is (b). 
     
     
         4 . The polynucleotide of  claim 1 , wherein said polynucleotide is (c). 
     
     
         5 . A method of diagnosing a disease or a susceptibility to a disease in a subject that is related to the presence of mutations in, or the production of, a nucleotide sequence, comprising collecting a sample from a subject and:
 (a) determining the presence or absence of a mutation in a nucleotide sequence encoding the polypeptide of SEQ ID NO:Y in the genome of said subject; and/or   (b) analyzing for the presence or amount of the nucleotide in said sample derived from said subject.   
     
     
         6 . The method of  claim 5 , wherein the polynucleotide is a fragment of the nucleotide sequence encoding the polypeptide of SEQ ID NO:Y. 
     
     
         7 . The method of  claim 6 , wherein the polynucleotide fragment comprises at least 30 consecutive nucleotides of the nucleotide sequence encoding the polypeptide of SEQ ID NO:Y 
     
     
         8 . The method of  claim 6 , wherein the polynucleotide fragment comprises at least 50 consecutive nucleotides of the nucleotide sequence encoding the polypeptide of SEQ ID NO:Y. 
     
     
         9 . An isolated polypeptide comprising an amino acid sequence that has at least 80% identity over its entire length to an amino acid sequence encoding the polypeptide of SEQ ID NO:Y. 
     
     
         10 . The polypeptide of  claim 9 , wherein the polypeptide comprises at least 30 consecutive amino acids of SEQ ID NO:Y. 
     
     
         11 . The polypeptide of  claim 9 , wherein the polypeptide comprises at least 50 consecutive amino acids of SEQ ID NO:Y.