Antibodies to hADA2

Abstract

Human polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for therapeutic purposes. Antagonists against such polypeptides and their use as a therapeutic are also disclosed. Also disclosed are diagnostic methods for detecting disease which utilize the sequences and polypeptides.

1 . An isolated polynucleotide comprising a polynucleotide having at least a 95% identity to a member selected from the group consisting of:
 (a) a polynucleotide encoding a polypeptide comprising the amino acid according to SEQ ID NO:12;   (b) a polynucleotide encoding a polypeptide comprising the amino acid according to SEQ ID NO:13;   (c) a polynucleotide encoding a polypeptide comprising the amino acid according to SEQ ID NO:14;   (d) a polynucleotide encoding a polypeptide comprising the amino acid according to SEQ ID NO:15;   (e) a polynucleotide encoding a polypeptide comprising the amino acid according to SEQ ID NO:16;   (f) a polynucleotide encoding a polypeptide comprising the amino acid according to SEQ ID NO:17;   (g) a polynucleotide encoding a polypeptide comprising the amino acid according to SEQ ID NO:18;   (h) a polynucleotide encoding a polypeptide comprising the amino acid according to SEQ ID NO:19;   (i) a polynucleotide encoding a polypeptide comprising the amino acid according to SEQ ID NO:20;   (j) a polynucleotide encoding a polypeptide comprising the amino acid according to SEQ ID NO:21;   (k) a polynucleotide encoding a polypeptide comprising the amino acid according to SEQ ID NO:22; and   (l) the complement of (a), (b), (c), (d), (e), (f), (g), (h), (i), (j), and (k).   
     
     
         2 . The isolated polynucleotide of  claim 1  wherein said member is (a). 
     
     
         3 . The isolated polynucleotide of  claim 1  wherein said member is (b). 
     
     
         4 . The isolated polynucleotide of  claim 1  wherein said member is (c). 
     
     
         5 . The isolated polynucleotide of  claim 1  wherein said member is (d). 
     
     
         6 . The isolated polynucleotide of  claim 1  wherein said member is (e). 
     
     
         7 . The isolated polynucleotide of  claim 1  wherein said member is (f). 
     
     
         8 . The isolated polynucleotide of  claim 1  wherein said member is (g). 
     
     
         9 . The isolated polynucleotide of  claim 1  wherein said member is (h). 
     
     
         10 . The isolated polynucleotide of  claim 1  wherein said member is (i). 
     
     
         11 . The isolated polynucleotide of  claim 1  wherein said member is (j). 
     
     
         12 . The isolated polynucleotide of  claim 1  wherein said member is (k). 
     
     
         13 . The isolated polynucleotide of  claim 1 , wherein the polynucleotide is DNA. 
     
     
         14 . A method of making a recombinant vector comprising inserting the isolated polynucleotide of  claim 1  into a vector, wherein said polynucleotide is DNA. 
     
     
         15 . A recombinant vector comprising the polynucleotide of  claim 1 , wherein the polynucleotide is DNA. 
     
     
         16 . A recombinant host cell comprising the polynucleotide of  claim 1 , wherein said polynucleotide is DNA. 
     
     
         17 . A method for producing a polypeptide comprising expressing from the recombinant cell of  claim 16  the polypeptide encoded by said polynucleotide. 
     
     
         18 . The isolated polynucleotide of  claim 1  comprising the nucleotide sequence which is a member selected from the group consisting of:
 (a) a polynucleotide comprising the sequence according to SEQ ID NO:1;   (b) a polynucleotide comprising the sequence according to SEQ ID NO:2;   (c) a polynucleotide comprising the sequence according to SEQ ID NO:3;   (d) a polynucleotide comprising the sequence according to SEQ ID NO:4;   (e) a polynucleotide comprising the sequence according to SEQ ID NO:5;   (f) a polynucleotide comprising the sequence according to SEQ ID NO:6;   (g) a polynucleotide comprising the sequence according to SEQ ID NO:7;   (h) a polynucleotide comprising the sequence according to SEQ ID NO:8;   (i) a polynucleotide comprising the sequence according to SEQ ID NO:9;   (j) a polynucleotide comprising the sequence according to SEQ ID NO: 10; and   (k) a polynucleotide comprising the sequence according to SEQ ID NO:11.   
     
     
         19 . An isolated polypeptide comprising a polypeptide having at least a 95% identity to a member selected form the group consisting of:
 (a) a polypeptide comprising the amino acid according to SEQ ID NO:12;   (b) a polypeptide comprising the amino acid according to SEQ ID NO:13;   (c) a polypeptide comprising the amino acid according to SEQ ID NO:14;   (d) a polypeptide comprising the amino acid according to SEQ ID NO:15;   (e) a polypeptide comprising the amino acid according to SEQ ID NO:16;   (f) a polypeptide comprising the amino acid according to SEQ ID NO:17;   (g) a polypeptide comprising the amino acid according to SEQ ID NO:18;   (h) a polypeptide comprising the amino acid according to SEQ ID NO:19;   (i) a polypeptide comprising the amino acid according to SEQ ID NO:20;   (j) a polypeptide comprising the amino acid according to SEQ ID NO:21; and   (k) a polypeptide comprising the amino acid according to SEQ ID NO:22.   
     
     
         20 . An antibody that specifically binds the polypeptide of  claim 19 . 
     
     
         21 . A method for identifying an antagonist of the polypeptide of  claim 19 , comprising:
 (a) contacting a cell expressing said polypeptide with a compound to be screened; and   (b) determining whether said compound acts as an antagonist of said polypeptide.   
     
     
         22 . A method for identifying an agonist of the polypeptide of  claim 19 , comprising:
 (a) contacting a cell expressing said polypeptide with a compound to be screened; and   (b) determining whether said compound acts as an agonist of said polypeptide.