Treatment of diseases using ice inhibitors

Abstract

This invention relates to methods and compositions for treating autoinflammatory diseases. The invention also assays for evaluating the ability of an ICE inhibitor to treat autoinflammatory diseases.

1 - 4 . (canceled) 
   
   
       5 . A method for ameliorating, treating, or preventing an autoinflammatory disease in a subject, comprising administering a compound that inhibits ICE or a pharmaceutical composition comprising said compound to said subject, wherein the compound is: 
     
       
         
         
             
             
         
       
       and each stereoisomer thereof, including: 
     
     
       
         
         
             
             
         
       
     
   
   
       6 . A method for ameliorating, treating, or preventing an autoinflammatory disease in a subject, comprising administering a compound that inhibits ICE or a pharmaceutical composition comprising said compound to said subject, wherein the compound is: 
     
       
         
         
             
             
         
       
       and each stereoisomer thereof, including: 
     
     
       
         
         
             
             
         
       
     
   
   
       7 - 13 . (canceled) 
   
   
       14 . The method according to  claim 5  or  6 , wherein the compound is administered to the subject at a dose selected from the group consisting of:
 (a) between about 300 mg to about 2,400 mg per administration;   (b) between about 600 mg to about 1,800 mg per administration; and   (c) about 900 mg per administration.   
   
   
       15 . The method according to  claim 5  or  6 , wherein the compound is administered to the subject at a dose selected from the group consisting of:
 (a) between about 2 mg per kg body weight to about 200 mg per kg body weight per day;   (b) between about 6 mg per kg body weight to about 100 mg per kg body weight per day; and   (c) between about 25 mg per kg body weight to about 75 mg per kg body weight per day.   
   
   
       16 . (canceled) 
   
   
       17 . A method for ameliorating or treating Cryopyrin-associated Periodic Syndromes, Muckle-Wells Syndrome, Familial Cold Autoinflammatory Syndrome, Familial Mediterranean Fever, Chronic Infantile Neurological Cutaneous and Articular Syndrome, Neonatal Onset Multisystem Inflammatory Disease, TNFR1-Associated Periodic Syndrome, Hyper-IgD periodic fever Syndrome, Blau's syndrome, systemic onset juvenile idiopathic arthritis, or macrophage activation syndrome in a subject, comprising administering a compound or a pharmaceutical composition comprising said compound to said subject, wherein said compound is: 
     
       
         
         
             
             
         
       
       and each stereoisomer thereof, including: 
     
     
       
         
         
             
             
         
       
     
   
   
       18 . A method for ameliorating or treating Cryopyrin-associated Periodic Syndromes, Muckle-Wells Syndrome, Familial Cold Autoinflammatory Syndrome, Familial Mediterranean Fever, Chronic Infantile Neurological Cutaneous and Articular Syndrome, Neonatal Onset Multisystem Inflammatory Disease, TNFR1-Associated Periodic Syndrome, Hyper-IgD periodic fever Syndrome, Blau's syndrome, systemic onset juvenile idiopathic arthritis, or macrophage activation syndrome in a subject, comprising administering a compound or a pharmaceutical composition comprising said compound to said subject, wherein said compound is: 
     
       
         
         
             
             
         
       
       and each stereoisomer thereof, including: 
     
     
       
         
         
             
             
         
       
     
   
   
       19 . The method according to any one of  claims 5 ,  6 ,  17  or  18 , wherein said compound or said pharmaceutical composition is administered orally, parenterally, by inhalation spray, topically, rectally, nasally, buccally, vaginally or via an implanted reservoir. 
   
   
       20 . The method according to any one of  claims 5 ,  6 ,  17  or  18 , wherein said compound or said pharmaceutical composition is used to ameliorate or treat Muckle-Wells Syndrome. 
   
   
       21 . The method according to any one of  claims 5 ,  6 ,  17  or  18 , wherein said compound or said pharmaceutical composition is used to ameliorate or treat Familial Cold Autoinflammatory Syndrome.