Peritoneal dialysis method

Abstract

A peritoneal dialysate containing adenosine triphosphate or a salt thereof, and a peritoneal dialysis method using the dialysate. The peritoneal dialysate is safe and causes less peritoneal injuries even when employed in peritoneal dialysis over a long period of time.

1 .- 20 . (canceled) 
   
   
       21 . A composition comprising water, glucose, electrolytes, and adenosine triphosphate or a salt thereof in a form suitable for use as a pertioneal dialysate. 
   
   
       22 . The composition of  claim 21 , which has an osmotic pressure of 300 to 700 mOsm/L. 
   
   
       23 . The composition of  claim 21 , which contains glucose in at a concentration of 1,000 to 4,000 mg/dL. 
   
   
       24 . The composition of  claim 21 , which contains glucose in at a concentration of 1,200 to 3,600 mg/dL. 
   
   
       25 . The composition of  claim 21 , which contains Na + , Ca 2+ , Mg 2+  and Cl −  as electrolytes. 
   
   
       26 . The composition of  claim 21 , which contains as electrolytes 100-200 mEq/L Na + , 4-5 mEq/L Ca 2+ , 1-2 mEq/L Mg 2+  and 80-120 mEq/L Cl − . 
   
   
       27 . The composition of  claim 21 , which contains 10-5,000 μM ATP or a salt thereof. 
   
   
       28 . The composition of  claim 21 , which contains 50-2,000 μM ATP or a salt thereof. 
   
   
       29 . The composition of  claim 21 , further comprising at least one organic acid in an amount ranging from 30-50 mEq/L. 
   
   
       30 . The composition of  claim 21 , further comprising lactic acid in an amount ranging from 30-50 mEq/L. 
   
   
       31 . The composition of  claim 21 , which has an osmotic pressure of 300 to 700 mOsm/L, and which contains:
 1,000 to 4,000 mg/dL glucose,   100-200 mEq/L Na + , 4-5 mEq/L Ca 2+ , 1-2 mEq/L Mg 2+  and 80-120 mEq/L Cl −  as electrolytes,   10-5,000 μM ATP or a salt thereof, and optionally   30-50 mEq/L of at least one organic acid.   
   
   
       32 . A peritoneal dialysis method comprising administering into the peritoneum of a subject in need thereof an effective amount of the composition of  claim 21 . 
   
   
       33 . The method of  claim 32 , wherein the composition is administered intraperitoneally via a catheter implanted in the peritoneal cavity. 
   
   
       34 . The method of  claim 32 , further comprising administering a dialysate containing a level of glucose above a physiological level of glucose
 wherein said dialyzate is administered after administering said composition and wherein said composition contains a physiological level of glucose ranging from 0.08 to 0.16% (w/v).   
   
   
       35 . The method of  claim 32 , wherein the subject has a renal disease. 
   
   
       36 . The method of  claim 32 , wherein said subject has cell injuries caused by exposure to high levels of sugar. 
   
   
       37 . The method of  claim 32 , wherein said subject has peritoneal mesothelial cell injuries caused by exposure to high levels of sugar. 
   
   
       38 . The method of  claim 32 , wherein said subject has hardening of the peritoneum or peritonitis. 
   
   
       39 . The method of  claim 32 , wherein said subject has sclerotic encysted peritonitis or intractable prolonged peritonitis. 
   
   
       40 . A peritoneal dialysis method comprising:
 administering into the peritoneum of a subject in need thereof an effective amount of a dialysate comprising water, glucose, electrolytes; and   administering a separate amount of adenosine triphosphate or a salt thereof, which is optionally administered orally, intravenously, intramuscularly, or locally.