Peptides Having Activities of Insulin Like Growth Factor-1 and their Uses

Abstract

The present invention relates to a peptide having the activity of insulin like growth factor-1 (IGF-1) and derived from IGF-1, a composition for improving skin conditions or treating a periodontal disease comprising the peptide. The IGF-1 mimicking peptides of this invention have identical functions or actions to natural-occurring IGF-1 and much better stability and skin permeation than natural-occurring IGF-1. In these connections, the composition comprising the peptides of this invention can exhibit excellent efficacies on the treatment, prevention and improvement of diseases or conditions demanding IGF-1 activities. In addition, the peptides of this invention can be advantageously applied to pharmaceutical compositions, quasi-drugs and cosmetics.

1 . A peptide having the activity of insulin like growth factor-1 (IGF-1) and derived from IGF-1, which comprises the amino acid sequence selected from SEQ ID NOs:2-8. 
     
     
         2 . The peptide according to  claim 1 , wherein a linker in the amino acid sequence of SEQ ID NO:6 is Ala-Ala dimer, amino hexanoic acid or amino butyric acid. 
     
     
         3 . The peptide according to  claim 1 , wherein the amino acid sequence of SEQ ID NO:6 is the amino acid sequence of SEQ ID NO:1. 
     
     
         4 . The peptide according to  claim 1 , wherein Cys residues present at the N-terminal and C-terminal of the amino acid sequence of SEQ ID NO:4 are linked to form a disulfide bond. 
     
     
         5 . The peptide according to  claim 1 , wherein the C-terminal of the peptide is modified to have a hydroxyl group (—OH) or an amino group (—NH 2 ). 
     
     
         6 . The peptide according to  claim 1 , wherein the N-terminal of the peptide is protected with a protection group selected from the group consisting of acetyl group, fluorenyl methoxy carbonyl group, formyl group, palmitoyl group, myristyl group, stearyl group or polyethylene glycol (PEG). 
     
     
         7 .- 11 . (canceled) 
     
     
         12 . A method for improving a skin condition or treating a periodontal disease, which comprises administering to a subject a composition comprising the peptide according to  claim 1  as an active ingredient. 
     
     
         13 . The method according to  claim 12 , wherein the composition comprises (a) a pharmaceutically effective amount of a peptide having the activity of insulin like growth factor-1 (IGF-1) and derived from IGF-1, which comprises the amino acid sequence selected from SEQ ID NOs:2-8; and (b) a pharmaceutically acceptable carrier. 
     
     
         14 . The method according to  claim 12 , wherein the composition comprises (a) a cosmetically effective amount of a peptide having the activity of insulin like growth factor-1 (IGF-1) and derived from IGF-1, which comprises the amino acid sequence selected from SEQ ID NOs:2-8; and (b) a cosmetically acceptable carrier. 
     
     
         15 . The method according to  claim 12 , wherein the improvement in the skin condition is the improvement in wrinkle or skin elasticity, the prevention of skin aging, the prevention of hair loss, the promotion of hair growth, the improvement in skin moisture, the removal of dark spots or the treatment of acne. 
     
     
         16 . The method according to  claim 12 , wherein the composition has the treatment efficacy on the periodontal disease and is toothpaste or a composition for mouth cleaning or mouth caring. 
     
     
         17 .- 21 . (canceled)