Novel anti-inflammatory androstane derivative

Abstract

According to one aspect of the invention, there is provided a compound of formula (I) and solvates thereof. There are also provided compositions containing the compound, processes for preparing it, and its use in therapy.

1 . A method of treating rhinitis and conjunctivitis in a human subject comprising administering to said human subject an effective amount of the compound of formula (I) 
     
       
         
         
             
             
         
       
     
   
   
       2 . The method of  claim 1 , wherein said effective amount of the compound of formula (I) is administered once per day. 
   
   
       3 . The method of  claim 2 , wherein said effective amount of the compound of formula (I) is administered once per day in 1 or 2 doses. 
   
   
       4 . The method of  claim 2 , wherein said effective amount of the compound of formula (I) is administered once per day in a single dose. 
   
   
       5 . The method of  claim 1  where said compound of formula (I) is contained in an aqueous formulation. 
   
   
       6 . The method of  claim 5 , wherein said compound of formula (I) is presented in said aqueous formulation as a suspension of finely divided solid particles suspended in an aqueous suspending media. 
   
   
       7 . The method of  claim 1 , wherein said compound is applied to the nasal mucosa of said human subject. 
   
   
       8 . A method of treating rhinitis and conjunctivitis in a human subject comprising administering to said human subject an effective amount of the compound of formula (I) 
     
       
         
         
             
             
         
       
     
     as a finely divided solid material suspended in an aqueous suspending media delivered to the nasal mucosa of said subject once per day in one or two doses.