US2009156562A1PendingUtilityA1

Novel colored solutions of injectable drugs and their pharmaceutically acceptable salts

28
Individually held — no corporate assignee on recordPriority: Nov 14, 2005Filed: Nov 13, 2006Published: Jun 18, 2009
Est. expiryNov 14, 2025(expired)· nominal 20-yr term from priority
Inventors:Peter D. Winch
A61K 31/05A61K 31/5415A61K 31/225A61K 47/22A61K 9/0019A61K 31/5517A61K 31/5513A61K 31/47A61K 31/58A61K 31/4748A61K 31/4709A61K 31/4164A61K 31/661A61K 31/55A61K 31/40A61K 31/135
28
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Claims

Abstract

The invention is directed to pharmaceutical compositions comprising colored solutions, colored emulsions, or colored powders of injectable pharmaceuticals wherein said pharmaceuticals are selected from the group consisting of muscle relaxants, hypnotics, induction agents, and anticholinergics. The formulations of the present invention may all be colored using fluorescein. Different colors may be achieved by either varying the concentration of fluorescein, or by combining fluorescein with another dye. The invention is also directed to methods involving the use of said pharmaceutical compositions.

Claims

exact text as granted — not AI-modified
1 - 285 . (canceled) 
     
     
         286 . A colored injectable pharmaceutical, wherein said color is derived from a dye comprising fluorescein. 
     
     
         287 . The colored injectable pharmaceutical of  claim 286 , wherein said color is derived from a dye comprising fluorescein and methylene blue. 
     
     
         288 . The colored injectable pharmaceutical of  claim 286 , wherein said color is derived from a dye comprising fluorescein and indigo carmine. 
     
     
         289 . The colored injectable pharmaceutical of  claim 286 , wherein said pharmaceutical is a muscle relaxant, and wherein said color is derived from a dye comprising fluorescein in the concentration of 7 mg/mL to 250 mg/mL, and wherein the color is bright orange. 
     
     
         290 . The colored injectable pharmaceutical of  claim 286 , wherein said pharmaceutical is a hypnotic, and wherein said color is derived from a dye comprising fluorescein in the concentration of 1 mg/mL to 10 mg/mL, and wherein the color is orange. 
     
     
         300 . The colored injectable hypnotic of  claim 290 , wherein said color is derived from a dye comprising fluorescein in the concentration of 1.5 mg/mL to 2.5 mg/mL, and wherein the color is orange. 
     
     
         301 . The colored injectable pharmaceutical of  claim 286 , wherein said pharmaceutical is a induction agent, and wherein said color is derived from a dye comprising fluorescein in the concentration of 0.001 mg/mL to 2.5 mg/mL, and wherein the color is yellow. 
     
     
         302 . The colored injectable pharmaceutical of  claim 286 , wherein said pharmaceutical is an anticholinergic, wherein said color is derived from a dye comprising fluorescein in the concentration of 0.001 mg/mL to 0.1 mg/mL and methylene blue in the concentration of 0.001 mg/mL to 0.05 mg/mL, and wherein the color is green. 
     
     
         303 . The colored injectable pharmaceutical of  claim 286 , wherein said pharmaceutical is an anticholinergic, wherein said color is derived from a dye comprising fluorescein in the concentration of 0.001 mg/mL to 0.4 mg/mL and indigo carmine in the concentration of 0.001 mg/mL to 0.05 mg/mL, and wherein the color is green. 
     
     
         304 . A method of preparing color coded injectable pharmaceuticals, wherein different colors are created by varying the concentration of fluorescein. 
     
     
         305 . The method of  claim 304 , wherein the colors yellow, orange, and bright orange are created by varying the concentration of fluorescein. 
     
     
         306 . The pharmaceutical composition of  claim 286 , wherein the pharmaceutical is atracurium besylate and wherein the color is bright orange. 
     
     
         307 . The pharmaceutical composition of  claim 286 , wherein the pharmaceutical is rocuronium and wherein the color is bright orange. 
     
     
         308 . The pharmaceutical composition of  claim 286 , wherein the pharmaceutical is vecuronium and wherein said color is bright orange. 
     
     
         309 . The pharmaceutical composition of  claim 286 , wherein the pharmaceutical is cisatracurium besylate and wherein the color is bright orange. 
     
     
         310 . The pharmaceutical composition of  claim 286 , wherein the pharmaceutical is pancuronium and wherein the color is bright orange. 
     
     
         311 . The pharmaceutical composition of  claim 286 , wherein the pharmaceutical is succinylcholine and wherein the color is bright orange. 
     
     
         312 . The pharmaceutical composition of  claim 286 , wherein the pharmaceutical is lorazepam and wherein said color is orange. 
     
     
         313 . The pharmaceutical composition of  claim 286 , wherein the pharmaceutical is midazolam hydrochloride and wherein said color is orange. 
     
     
         314 . The pharmaceutical composition of  claim 286 , wherein the pharmaceutical is diazepam and wherein said composition is a solution and said color is orange. 
     
     
         315 . The pharmaceutical composition of  claim 286 , wherein the pharmaceutical is etomidate and wherein the color is yellow. 
     
     
         316 . The pharmaceutical composition of  claim 286 , wherein the pharmaceutical is propofol and wherein the color is yellow. 
     
     
         317 . The pharmaceutical composition of  claim 286 , wherein the pharmaceutical is fospropofol disodium and wherein the color is yellow. 
     
     
         318 . The pharmaceutical composition of  claim 286 , wherein the pharmaceutical is fospropofol disodium and wherein the color is orange. 
     
     
         319 . The pharmaceutical composition of  claim 286 , wherein the pharmaceutical is ketamine hydrochloride and wherein the color is yellow. 
     
     
         320 . The pharmaceutical composition of  claim 286 , wherein the pharmaceutical is atropine, and wherein the color is green derived from fluorescein and methylene blue. 
     
     
         321 . The pharmaceutical composition of  claim 286 , wherein the pharmaceutical is atropine, and wherein the color is green derived from fluorescein and indigo carmine. 
     
     
         322 . The pharmaceutical composition of  claim 286 , wherein the pharmaceutical is glycopyrrolate and wherein the color is green derived from fluorescein and methylene blue. 
     
     
         323 . The pharmaceutical composition of  claim 286 , wherein the pharmaceutical is glycopyrrolate and wherein the color is green derived from fluorescein and indigo carmine. 
     
     
         324 . The pharmaceutical composition of  claim 286 , wherein the pharmaceutical is gantacurium and wherein the color is bright orange. 
     
     
         325 . The pharmaceutical composition of  claim 286 , wherein the pharmaceutical is mivacurium and wherein the color is bright orange.

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