Formulation for controlled release of drugs by combining hydrophilic and hydrophobic agents

Abstract

Combinations of hydrophilic and hydrophobic entities in a biodegradable sustained release implant are shown to modulate each other's rate of release. Formulations of a therapeutically active agent and modulator provide substantially constant rate of release for an extended period of time.

1 . A monolithic implant for treating an ocular condition, the implant comprising:
 (a) a biodegradable polymeric matrix;   (b) an anti-inflammatory steroid homogenously distributed through the polymeric matrix, and;   (c) a saccharide for modifying release of the steroid from the polymeric matrix.   
   
   
       2 . The implant of  claim 1 , wherein the saccharide is a monosaccharide, a disaccharide or a polysaccharide. 
   
   
       3 . The implant of  claim 1  wherein the polymeric matrix comprises a copolymer of glycolic and lactic acid. 
   
   
       4 . A method for treating an ocular condition, the method comprising the step of administering to the vitreous cavity of an eye, a monolithic implant comprising a biodegradable polymeric matrix, an anti-inflammatory steroid homogenously distributed through the polymeric matrix, and a saccharide for modifying release of the steroid from the polymeric matrix.