Use of flavonoids as immunomodulating or immuno-protective agents in cosmetic and dermatological preparations

Abstract

A method of treating or prophylactically treating immunosuppression or allergic and inflammatory symptoms of skin caused by UVB radiation which comprises applying to the skin a cosmetic or dermatological composition which comprises one or more flavonoids.

1 . A method of treating or prophylactically treating immunosuppression of skin cells induced by UVB radiation, wherein the method comprises topically applying to skin of a person in need thereof an effective amount therefor of a cosmetic or dermatological composition comprising one or more compounds selected from chalcones and glycosides thereof. 
   
   
       2 . The method of  claim 1 , wherein immunosuppression is treated. 
   
   
       3 . The method of  claim 1 , wherein the composition further comprises one or more cinnamic acid derivatives. 
   
   
       4 . The method of  claim 1 , wherein the composition further comprises one or more antioxidants. 
   
   
       5 . The method of  claim 4 , wherein the one or more antioxidants comprise at least one of tocopherol and a derivative thereof. 
   
   
       6 . The method of  claim 1 , wherein the composition further comprises one or more of alpha-glucosylrutin, alpha-glucosylmyricitrin, alpha-glucosylquercitrinin, alpha-glucosylquercitrin, rutin, chrysin, kaempferol, myricetin, rhamnetin, apigenin, luteolin, naringin, hesperidin, naringenin, hesperitin, morin, phloridzin, diosmin, fisetin, vitexin, neohesperidin, flavone and genistein. 
   
   
       7 . The method of  claim 1 , wherein the composition comprises from 0.01% to 10% by weight of the one or more compounds, based on a total weight of the composition. 
   
   
       8 . The method of  claim 7 , wherein the composition comprises from 0.1% to 6% by weight of the one or more compounds. 
   
   
       9 . The method of  claim 1 , wherein the cosmetic or dermatological composition comprises an emulsion. 
   
   
       10 . The method of  claim 1 , wherein the cosmetic or dermatological composition comprises a gel. 
   
   
       11 . A method for treating or prophylactically treating one or more of allergic and inflammatory symptoms of skin caused by UVB radiation, wherein the method comprises topically applying to the skin a cosmetic or dermatological composition comprising one or more compounds selected from alpha-glucosylrutin, alpha-glucosylmyricitrin, alpha-glucosylquercitrinin, alpha-glucosylquercitrin, quercetin, rutin, chrysin, kaempferol, myricetin, rhamnetin, apigenin, luteolin, naringin, hesperidin, naringenin, hesperitin, morin, phloridzin, diosmin, fisetin, vitexin, neohesperidin, dihydrochalcone, flavone, genistein, and chalcones and glycosides thereof. 
   
   
       12 . The method of  claim 11 , wherein allergic symptoms are treated or prophylactically treated. 
   
   
       13 . The method of  claim 11 , wherein allergic symptoms are treated or prophylactically treated. 
   
   
       14 . The method of  claim 11 , wherein the composition further comprises one or more antioxidants. 
   
   
       15 . The method of  claim 14 , wherein the one or more antioxidants comprise at least one of tocopherol and a derivative thereof. 
   
   
       16 . The method of  claim 11 , wherein the composition comprises from 0.01% to 10% by weight of the one or more compounds, based on a total weight of the composition. 
   
   
       17 . The method of  claim 16 , wherein the composition comprises from 0.1% to 6% by weight of the one or more compounds. 
   
   
       18 . The method of  claim 11 , wherein the cosmetic or dermatological composition comprises an emulsion. 
   
   
       19 . The method of  claim 11 , wherein the cosmetic or dermatological composition comprises a gel. 
   
   
       20 . The method of  claim 11 , wherein the one or more compounds comprise alpha-glucosylrutin.