Apparatus and method for autologous normovolemic hemodilution

Abstract

A system and method for autologous normovolemic hemodilution (ANH) are disclosed. The system can include a vacuum canister, which is sized to accept donor bags of a predetermined capacity. The vacuum canister is connected to a vacuum source which applies a suction to the donor bag within the canister. The system can include a canister having a self-generated vacuum, which includes compressible sidewalls that are spring-loaded to provide negative pressure needed to collect blood from a patient without the use of a gravity-induced siphon gradient. Also disclosed are ANH systems and kits that rely on a gravity-induced siphon gradient for blood collection.

1 . An autologous normovolemic hemodilution (ANH) blood collection device comprising a canister that defines an internal volume for receiving a blood collection bag, the canister including a blood inlet port and a vacuum inlet port; and
 wherein the canister is openable and provides a substantially air-tight seal around the blood collection bag.   
   
   
       2 . The device of  claim 1 , wherein the canister defines an internal volume that limits the volume of blood collected within the blood collection bag. 
   
   
       3 . The device of  claim 1 , wherein the canister is configured to define an internal volume having a size and shape substantially corresponding to a blood collection bag filled to a desired maximum volume. 
   
   
       4 . The device of  claim 1 , wherein the canister is hinged. 
   
   
       5 . The device of  claim 1 , wherein the canister is openable and provides a seal around the blood collection bag that is suitable for supporting a vacuum of at least −25 millimeters of Mercury. 
   
   
       6 . The device of  claim 1 , wherein the canister is substantially transparent or substantially translucent. 
   
   
       7 . The device of  claim 6 , wherein an outer surface of the canister includes a plurality of volume-indicating markings. 
   
   
       8 . A system for ANH blood collection comprising the device of  claim 1 , and a vacuum source in substantially air-tight communication with the canister via tubing. 
   
   
       9 . The system of  claim 8 , further comprising a blood collection line between a draw point on a patient and the blood input port on the device. 
   
   
       10 . The system of  claim 8 , wherein the vacuum source evacuates the internal volume of the canister, thereby generating a negative pressure within the collection bag of sufficient magnitude to draw blood from the patient through the collection line. 
   
   
       11 . The system of  claim 10 , wherein the blood collection device is disposed at a vertical height that is at least as high as the vertical height of a draw point on the patient. 
   
   
       12 . An autologous normovolemic hemodilution (ANH) blood collection device comprising:
 a canister having resilient, compressible sidewalls;   a compression device operative to compress the canister; and   wherein the resilient canister sidewalls are operative to return to an decompressed state following compression, thereby generating a negative pressure within the canister of sufficient magnitude to draw blood from a patient.   
   
   
       13 . The device of  claim 12 , wherein the sidewalls include flexible outer wall members and an integral coil member. 
   
   
       14 . The device of  claim 12 , wherein the compression device is a rotatable compression knob. 
   
   
       15 . The device of  claim 12 , further comprising an agitator connected to a drive mechanism within the canister. 
   
   
       16 . The device of  claim 15 , wherein the drive mechanism includes a lower portion threadably engaging an upper portion, the upper portion being connected to the compression knob. 
   
   
       17 . The device of  claim 16 , wherein the drive mechanism rotates as the canister returns to an uncompressed state, the rotation rotating the agitator within the canister. 
   
   
       18 . The device of  claim 16 , wherein at least one of the internal portion of the sidewalls, the agitator and the drive mechanism are coated with an anticoagulant. 
   
   
       19 . The device of  claim 12 , wherein the canister includes a blood reinfusion port and a blood input port. 
   
   
       20 . A system for ANH blood collection comprising the device of  claim 19 , a blood collection line between a draw point on a patient and the blood input port on the device. 
   
   
       21 . The system of  claim 20 , wherein the blood collection device is disposed at a vertical height that is at least as high as the vertical height of a draw point on the patient. 
   
   
       22 . The system of  claim 20 , further comprising a pressure regulator disposed along the blood collection line in fluid communication with the patient and the blood collection device. 
   
   
       23 . A device for collecting blood from a patient through a blood collection line, the device comprising a canister in fluid communication with the patient, the canister being configured to self-generate an internal negative pressure of sufficient magnitude to draw blood from the patient.