Methods of treating infection

Abstract

The present invention relates to methods of inhibiting the proliferation of bacteria for either ex vivo or in vivo use. The invention also relates to methods of treating a patient infected with an antibiotic resistant bacteria by administering a pharmaceutical composition comprising an Empedopeptin; methods of sanitizing surfaces and instruments; and methods of assaying bacteria for Empedopeptin resistance.

1 . A method of inhibiting bacterial proliferation comprising:
 providing a pharmaceutical composition comprising Empedopeptin or a pharmaceutically acceptable salt thereof,   wherein the bacteria comprises at least one Gram positive strain, and the Gram positive strain is resistant to glycopeptides, aminoglycosides, oxazolidinones, penicillins, macrolides, rifamycins, polypeptides, lipopeptides, chloramphenicol, or any combination thereof.   
     
     
         2 . The method of  claim 1 , wherein the Gram positive strain further comprises  Enterococcus faecalis, Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae, Streptococcus pyogenes , or any combination thereof. 
     
     
         3 . The method of  claim 2 , wherein the Gram positive strain is further resistant to at least one of linezolid, oxacillin, vancomycin, daptomycin, erythromycin, methicillin, gentamicin, chloramphenicol, fusidic acid, rifampin, or combinations thereof. 
     
     
         4 . The method of  claim 1 , further comprising providing a second pharmaceutical composition, wherein the second pharmaceutical composition comprises a second antibiotic agent. 
     
     
         5 . An isolated nucleotide sequence comprising SEQ ID NO 1. 
     
     
         6 . An isolated protein sequence comprising SEQ ID NO 2. 
     
     
         7 . An isolated nucleotide sequence comprising SEQ ID NO 3. 
     
     
         8 . An isolated protein sequence comprising SEQ ID NO 4. 
     
     
         9 . An isolated nucleotide sequence comprising SEQ ID NO 5. 
     
     
         10 . An isolated protein sequence comprising SEQ ID NO 6. 
     
     
         11 . An isolated nucleotide sequence comprising SEQ ID NO 7 
     
     
         12 . An isolated protein sequence comprising SEQ ID NO 8.