Composition Comprising a Colloidal Synthetic Bioresorbable Vector and a Viral Vector

Abstract

The invention relates to pharmaceutical compositions containing a colloidal synthetic bioresorbable vector which comprises at least one type of proteinic substance, to a viral vector corresponding to at least one type of proteinic substance of the synthetic vector and to a method for the prophylactic, therapeutic and diagnosis use thereof.

1 . Pharmaceutical composition comprising
 a colloidal synthetic bioresorbable vector comprising at least one protein substance, and   a viral vector comprising at least one nucleotide sequence which codes for a protein substance corresponding to at least one protein substance of the synthetic vector.   
     
     
         2 . Composition according to  claim 1 , wherein it comprises a vector of spherical nature as the colloidal synthetic vector. 
     
     
         3 . Composition according to  claim 1 , wherein the colloidal synthetic vector is prepared from at least one polymer chosen from amongst the poly(α-hydroxy acids). 
     
     
         4 . Composition according to  claim 1 , wherein the colloidal synthetic vector is prepared from at least one natural polymer. 
     
     
         5 . Composition according to  claim 1 , wherein the colloidal synthetic vector comprises protein substances of different types, each constituting an antigen associated with the same disease. 
     
     
         6 . Composition according to the  claim 1 , wherein it comprises an adenovirus or a poxvirus as the viral vector. 
     
     
         7 . Composition according to  claim 6 , wherein the poxvirus is the Modified Vaccinia Virus Ankara. 
     
     
         8 . Composition according to  claim 1 , wherein the protein substances are of viral origin. 
     
     
         9 . Composition according to  claim 8 , wherein the protein substances of viral origin are proteins of the HIV virus. 
     
     
         10 . Composition according to  claim 1 , wherein the protein substance is an antigen associated with tumours. 
     
     
         11 . A method for preparing a medicament, comprising:
 utilizing the composition of  claim 1 .   
     
     
         12 . A method for preparing a vaccine, comprising:
 utilizing the composition of  claim 1 .   
     
     
         13 . A method for diagnosing in vitro of the pathological state for which the protein substance or substances of the synthetic vector a constitute antigens, comprising:
 utilizing the composition of  claim 1 .   
     
     
         14 . The method according to  claim 13 , wherein the pathological state is a viral infection. 
     
     
         15 . The method according to  claim 13 , wherein the pathological state is a cancer. 
     
     
         16 . Method of prophylactic or therapeutic treatment, in particular vaccination, comprising the administration to a patient of an effective dose of the composition as defined in  claim 1 . 
     
     
         17 . Method of treatment according to  claim 16 , wherein the composition is administered in a staggered manner. 
     
     
         18 . Method of treatment according to  claim 17 , wherein the synthetic vector is administered before the viral vector.