Medicament dispensing device, medicament magazine therefor and method of removing a medicament from a medicament chamber

Abstract

The invention relates to a medicament dispensing device, particularly a multi-dose powder inhaler, a medicament magazine thereof, and a method of removing a medicament from the medicament magazine as depicted in exemplary FIG. 1 . The inhaler has a mouthpiece ( 9 ) and an air channel ( 4 ) connected thereto, as well as a medicament magazine with at least one medicament chamber containing a powdered medicament. A drive current is produced in the air channel, while a vacuum flow ( 5 ′) can be produced by the drive current and a constriction formed in the air channel. This narrowest part of the air channel that produces the vacuum flow is connected to a removal opening ( 2 ) which communicates with a control opening ( 3 ), in order to form an emptying current through the control opening via the removal opening. In a preferred embodiment the at least one medicament chamber including the control opening, the removal opening and a fill opening are housing in the one-piece medicament magazine.

1 - 24 . (canceled) 
   
   
       25 . Medicament dispensing device comprising a mouthpiece ( 9 ) and an air channel ( 4 ) connected therewith, as well as a medicament magazine with at least one medicament chamber containing a medicament, wherein a drive current comprising a vacuum flow can be generated in the air channel, characterised in that a most narrow region of the air channel that produces the vacuum flow, is connected to a removal opening ( 2 ) provided by the medicament magazine, this removal opening being connected to a control opening ( 3 ), to form an emptying current through the control opening via the removal opening. 
   
   
       26 . Medicament dispensing device according to  claim 25 , wherein the control and removal openings ( 3 , 2 ) are provided in the medicament magazine. 
   
   
       27 . Medicament dispensing device according to  claim 25 , wherein a bypass opening ( 8 ) is provided in the air channel ( 4 ) for forming a bypass flow, the bypass opening being arranged downstream of the removal opening ( 2 ) in the direction of the mouthpiece ( 9 ). 
   
   
       28 . Medicament dispensing device according to  claim 25 , having a throttle arrangement for varying the amount of medicament removed per unit of time. 
   
   
       29 . Medicament dispensing device according to  claim 28 , wherein the throttle arrangement comprises the control opening ( 3 ), the removal opening ( 2 ), the inner configuration of the medicament chamber and the configuration of the air channel connected to the removal opening. 
   
   
       30 . Medicament dispensing device according to one of  claim 25  for administering a medicament that contains an active substance or a combination of active substances selected from among the group of betamimetics, anticholinergics, steroids, antiallergics, ergot alkaloid derivatives, triptanes, CGRP antagonists, the phosphodiesterase-V inhibitors, phosphodiesterase-IV inhibitors, LTD4-antagonists, EGFR-kinase inhibitors. 
   
   
       31 . Medicament magazine ( 1 ) comprising a plurality of medicament chambers, each having at least one opening for the removal ( 2 ) of a medicament, characterised in that the medicament chamber has a fill opening ( 13 ) and the removal opening ( 2 ) is connected to a control opening ( 3 ), wherein the removal opening ( 2 ) can be attached to a vacuum flow in order to form an emptying current through the control opening ( 3 ) via the removal opening ( 2 ), and wherein the removal opening, the control opening and the fill opening are spaced from one another. 
   
   
       32 . Medicament magazine according to  claim 31 , wherein the removal opening ( 2 ) and control opening ( 3 ) are integrated and predefined in the medicament magazine. 
   
   
       33 . Medicament magazine ( 1 ) comprising a plurality of medicament chambers having at least one opening for the removal ( 2 ) of a medicament, characterised in that the medicament chamber has a fill opening ( 13 ) and the removal opening ( 2 ) is connected to a control opening ( 3 ), the removal opening ( 2 ) being connectable to a vacuum flow in order to produce an emptying current through the control opening ( 3 ) via the removal opening ( 2 ) and wherein the removal opening ( 2 ) and control opening ( 3 ) are integrated and predefined in the medicament magazine. 
   
   
       34 . Medicament magazine according to  claim 33 , wherein the fill opening ( 13 ), removal opening ( 2 ) and control opening ( 3 ) are arranged at a spacing from one another. 
   
   
       35 . Medicament magazine according to  claim 31 , wherein the magazine is annular and a plurality of medicament chambers are arranged in a ring in the magazine. 
   
   
       36 . Medicament magazine according to  claim 31 , wherein the fill opening ( 13 ) is arranged in a side of the magazine opposite the removal and control opening ( 2 , 3 ). 
   
   
       37 . Medicament magazine according to  claim 31 , wherein the fill opening ( 13 ) is arranged on the same side of the magazine as the removal and control opening ( 2 , 3 ). 
   
   
       38 . Medicament magazine according to  claim 31 , wherein a turbulence element ( 7 ) is arranged in the medicament chamber. 
   
   
       39 . Medicament magazine according to  claim 38 , wherein the turbulence element ( 7 ) is formed by at least a part of the wall of the medicament chamber. 
   
   
       40 . Medicament magazine according to  claim 31 , produced in one piece by injection moulding. 
   
   
       41 . Multi-dose powder inhaler comprising a medicament magazine according to  claim 31 . 
   
   
       42 . Multi-dose powder inhaler according to  claim 41 , comprising  60  medicament chambers with single doses of medicament. 
   
   
       43 . Method of removing a medicament from a medicament chamber, wherein a medicament is removed from the medicament chamber by the formation of a vacuum flow, and wherein the vacuum flow produces an emptying current through the medicament chamber, characterised in that the vacuum flow is part of a drive current ( 5 ) and is connected to a removal opening ( 2 ), defined by the medicament magazine, which removal opening is connected to the medicament chamber, wherein the emptying current is not connected with the drive current before entering the medicament chamber. 
   
   
       44 . Method according to  claim 43 , wherein the quantity of medicament to be removed per unit of time is determined by the strength of the emptying current, while the latter can be varied by means of a throttle arrangement. 
   
   
       45 . Method according to  claim 43 , wherein at least some of the emptying current flows away over the medicament contained in the medicament chamber. 
   
   
       46 . Method according to  claim 43 , wherein an additional vacuum flow in the medicament chamber is produced by means of an inner configuration of the medicament chamber. 
   
   
       47 . Method according to  claim 43 , wherein a medicament is emptied into a preliminary chamber ( 105 ) which is attached to a vacuum flow via a removal opening ( 2 ) for the removal of the medicament. 
   
   
       48 . Method according to  claim 43 , wherein a medicament chamber is opened before the removal of medicament, by piercing, scraping off or peeling a sealing foil ( 14 ) that closes off the medicament chamber.