Treatment of dna damage related disorders

Abstract

The present invention provides methods and compositions for prophylaxis and treatment of a variety of disorders including DNA damage related disorders, cancer, ischemia, oxidative stress, atherosclerosis, and stroke using a chloroquine compound.

1 .- 61 . (canceled) 
     
     
         62 . A method for treating atherosclerosis comprising administering to a subject in need thereof, an effective amount of a chloroquine compound. 
     
     
         63 . The method of  claim 62 , wherein the chloroquine compound is selected from the group consisting of chloroquine, chloroquine phosphate, hydroxychloroquine, chloroquine diphosphate, chloroquine sulphate, hydroxychloroquine sulphate, or enantiomers, derivatives, analogs, metabolites, pharmaceutically acceptable salts, and mixtures thereof. 
     
     
         64 . The method of  claim 63 , wherein the chloroquine compound is chloroquine diphosphate. 
     
     
         65 . The method of  claim 62 , wherein the chloroquine compound is administered intravenously. 
     
     
         66 . The method of  claim 62 , wherein the chloroquine compound is administered orally. 
     
     
         67 . The method of  claim 62 , wherein the administering is performed at regular intervals for a period of at least six months. 
     
     
         68 . The method of  claim 62 , wherein the chloroquine compound is administered systemically. 
     
     
         69 . The method of  claim 62 , wherein the subject is human. 
     
     
         70 . The method of  claim 69 , wherein the administration dosage of the chloroquine compound is 0.05 to 1 mg/kg per day. 
     
     
         71 . The method of  claim 70 , wherein the dosage is 0.2 to 0.6 mg/kg per day. 
     
     
         72 . The method of  claim 62 , wherein the amount of the compound administered is up to about 10 mg/kg/day. 
     
     
         73 . The method of  claim 62 , wherein the amount of the compound administered is more than about 0.1 mg/kg/day. 
     
     
         74 . The method of  claim 62 , wherein the amount of the compound administered is more than about 1.0 mg/kg/day. 
     
     
         75 . The method of  claim 62 , wherein the amount of the compound administered is less than about 50 mg/kg/day. 
     
     
         76 . The method of  claim 62 , wherein the amount of the compound administered is less than about 10 mg/kg/day. 
     
     
         77 . The method of  claim 62 , wherein the chloroquine compound is administered more than once a week. 
     
     
         78 . The method  claim 62 , wherein the chloroquine compound is administered daily. 
     
     
         79 . The method of  claim 62 , wherein the chloroquine compound is formulated in a sustained release formulation. 
     
     
         80 . The method of  claim 62 , further comprising administering one or more additional active agents to the subject. 
     
     
         81 . The method of  claim 80 , wherein one or more additional agents are selected from the group consisting of antiplatelet agents, lipid lowering agents, bile acid sequestrants, fibrinates, HMG-CoA reductase inhibitors, nocotinic acid derivatives, and blood pressure lowering agents. 
     
     
         82 . The method of  claim 62 , wherein the subject is free of psoriasis, malaria, protozoal infections, Alzheimer's disease, Parkinson's disease, lupus erythematosus, rheumatism, hypercalcemia, multiple sclerosis.