US2009098615A1PendingUtilityA1
Genetically modified cells and methods for converting (r)-methylmalonyl coa to (s)-methylmalonyl coa
Est. expiryOct 27, 2019(expired)· nominal 20-yr term from priority
C12P 19/62C12N 9/90C12P 11/00
58
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Claims
Abstract
Recombinant Escherichia coli host cells that comprise recombinant DNA expression vectors that drive expression of methylmalonyl CoA mutase from Propionibacterium shermanii or Streptomyces cinnamonensis as well as Propionibacterium shermanii epimerase can produce S-methylmalonyl CoA, a required substrate for the production of polyketides by most modular polyketide synthases not present in wild-type E. coli host cells.
Claims
exact text as granted — not AI-modified1 . A method for converting (R)-methylmalonyl CoA to (S)-methylmalonyl CoA in a host cell, the method comprising culturing the host cell of claim 22 under conditions such that said epimerase is expressed, and (R)-methylmalonyl CoA is converted into (S)-methylmalonyl CoA.
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