Therapeutic or prophylactic agent for allergic dermatitis

Abstract

A therapeutic or prophylactic agent for allergic dermatitis is disclosed. The therapeutic or prophylactic agent comprises as an effective ingredient a glycine derivative having a specific structure or a pharmaceutically acceptable salt thereof, for example, the below-described compound [(E)-2-(2,6-dichlorobenzamido)-5-[4-(isopropyl-pyrimidin-2-ylamino)phenyl]pent-4-enoic acid]. The therapeutic or prophylactic agent for allergic dermatitis according to the present invention has high therapeutic or prophylactic effect.

1 . A therapeutic or prophylactic agent for allergic dermatitis comprising as an effective ingredient (a) a compound of Formula (I): 
     
       
         
         
             
             
         
       
       wherein 
       R 1  represents hydrogen or C 1 -C 5  alkyl; 
       X independently represents fluoro, chloro, bromo, iodo or C 1 -C 3  alkyl; 
       V represents —CH═CH— or —C≡C—; 
       Y represents Formula (II) or Formula (III): 
     
     
       
         
         
             
             
         
       
       wherein 
       R 2  represents C 1 -C 5  alkyl or C 1 -C 3  alkoxy; 
       R 3  represents hydrogen or C 1 -C 5  alkyl; 
       m represents an integer of 0 to 3; 
       n represents 0 or 1; 
       p represents an integer of 0 to 2; 
       W represents —O— or —N(R 4 )— 
       wherein 
       R 4  represents hydrogen, C 1 -C 5  alkyl, C 3 -C 6  alkenyl, phenyl, benzyl, benzyl substituted with one or two R 5 s, tetrahydropyranyl, —(CH 2 ) q —O—CH 3 , pyridylmethyl, —(CH 2 ) q —CN, C 4 -C 7  cycloalkylmethyl or thiazol-4-ylmethyl; 
       R 5  represents hydroxy or C 1 -C 3  alkoxy; and 
       q represents an integer of 1 to 3; 
       or (b) a pharmaceutically acceptable salt of the compound of said Formula (I). 
     
   
   
       2 . The therapeutic or prophylactic agent of  claim 1 , wherein in said Formula (I),
 V is —CH═CH—; and   when Y is represented by the Formula (II), m is 0; or   when Y is represented by the Formula (III), p is 1.   
   
   
       3 . The therapeutic or prophylactic agent of  claim 2 , wherein in Formula (I),
 R 1  is hydrogen; and   when Y is represented by the Formula (II), W is —N(R 4 )— and R 4  is C 1 -C 3  alkyl, cyanoethyl, tetrahydropyranyl or phenyl; or   when Y is represented by the Formula (III), n is 0 and R 3  is C 1 -C 3  alkyl.   
   
   
       4 . The therapeutic or prophylactic agent of  claim 3 , wherein in Formula (I),
 X is independently chloro or methyl;   V is trans —CH═CH—; and   when Y is represented by the Formula (II), W is —N(R 4 )— and R 4  is methyl or isopropyl; or   when Y is represented by the Formula (III), R 3  is methyl.   
   
   
       5 . A method of producing a therapeutic or prophylactic agent for allergic dermatitis comprising using the compound of the Formula (I) or the pharmaceutically acceptable salt thereof recited  claim 1  for the production of the therapeutic or prophylactic agent for allergic dermatitis. 
   
   
       6 . A therapeutic or prophylactic method for allergic dermatitis, comprising administering to a patient an effective amount of the compound of the Formula (I) or the pharmaceutically acceptable salt thereof recited in  claim 1 . 
   
   
       7 . A method of producing a therapeutic or prophylactic agent for allergic dermatitis comprising using the compound of the Formula (I) or the pharmaceutically acceptable salt thereof recited  claim 2  for the production of the therapeutic or prophylactic agent for allergic dermatitis. 
   
   
       8 . A therapeutic or prophylactic method for allergic dermatitis, comprising administering to a patient an effective amount of the compound of the Formula (I) or the pharmaceutically acceptable salt thereof recited in  claim 2 . 
   
   
       9 . A method of producing a therapeutic or prophylactic agent for allergic dermatitis comprising using the compound of the Formula (I) or the pharmaceutically acceptable salt thereof recited  claim 3  for the production of the therapeutic or prophylactic agent for allergic dermatitis. 
   
   
       10 . A therapeutic or prophylactic method for allergic dermatitis, comprising administering to a patient an effective amount of the compound of the Formula (I) or the pharmaceutically acceptable salt thereof recited in  claim 3 . 
   
   
       11 . A method of producing a therapeutic or prophylactic agent for allergic dermatitis comprising using the compound of the Formula (I) or the pharmaceutically acceptable salt thereof recited  claim 4  for the production of the therapeutic or prophylactic agent for allergic dermatitis. 
   
   
       12 . A therapeutic or prophylactic method for allergic dermatitis, comprising administering to a patient an effective amount of the compound of the Formula (I) or the pharmaceutically acceptable salt thereof recited in  claim 4 .