4-Pyrimidineamine Compounds And Uses As Anti-Proliferative Agents

Abstract

The present disclosure provides 4-pyrimidineamine compounds having antiproliferative activity, compositions comprising the compounds and methods of using the compounds to inhibit cellular proliferation and to treat proliferative diseases such as tumorigenic cancers.

1 - 24 . (canceled) 
   
   
       25 . A compound selected from the group consisting of: 
     
       
         
               
             
                   
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
                   
               
               
               
               
               
               
             
                 R 2   
                 R 4′   
                 R 8   
                 R 9   
                 R 10   
               
                   
               
               
               
               
               
             
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                 and 
               
                   
               
               
               
               
               
             
                 
                   
                     
                     
                         
                         
                     
                   
                 
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       26 . A composition comprising a compound according to  claim 25  and a pharmaceutically acceptable carrier, excipient and/or diluent. 
   
   
       27 . The composition of  claim 26  which is packaged in unit dosage form. 
   
   
       28 . A method of inhibiting proliferation of a breast, colon, pancreatic, lung, bone, or renal tumor cell comprising contacting the cell with an amount of a compound according to  claim 25  effective to inhibit its proliferation: 
   
   
       29 . A method of treating a cancer selected from breast cancer, colon cancer, pancreatic cancer, lung cancer, renal cancer, and bone cancer, comprising administering to a subject in need thereof an amount of a compound according to  claim 25  effective to treat the proliferative disease. 
   
   
       30 . The method of  claim 29  in which the cancer is a metastatic tumor. 
   
   
       31 . The method of  claim 29  in which the compound is administered in the form of a pharmaceutical composition. 
   
   
       32 . The method of  claim 29  in which the compound is administered orally. 
   
   
       33 . The method of  claim 29  in which the compound is administered intravenously. 
   
   
       34 . The method of  claim 29  in which the subject is a human.