Thrombin Receptor Antagonists

Abstract

A series of compounds represented by the structural formulas and pharmaceutically acceptable isomers, salts, solvates and polymorphs thereof are disclosed. Also disclosed are pharmaceutical compositions containing said compounds and their use as thrombin receptor antagonists and binders to cannabinoid receptors.

1 . A compound represented by any of the following structural formulas 
     
       
         
         
             
             
         
       
       
         
         
             
             
         
       
     
     or a pharmaceutically acceptable isomer, salt, solvate or polymorph thereof. 
   
   
       2 . A pharmaceutical composition comprising an effective amount of at least one compound of  claim 1  and at least one pharmaceutically acceptable carrier. 
   
   
       3 . A method of inhibiting thrombin receptors comprising administering to a mammal in need of such treatment an effective amount of at least one compound of  claim 1 . 
   
   
       4 . A method of inhibiting cannabinoid receptors comprising administering to a mammal in need of such treatment an effective amount of at least one compound of  claim 1 . 
   
   
       5 . A method of treating thrombosis, platelet aggregation, coagulation, cancer, inflammatory diseases or respiratory diseases comprising administering to a mammal in need of such treatment an effective amount of at least one compound of  claim 1 . 
   
   
       6 . A method of treating atherosclerosis, restenosis, hypertension, angina pectoris, arrhythmia, heart failure, myocardial infarction, glomerulonephritis, thrombotic stroke, thromboembolytic stroke, peripheral vascular diseases, cerebral ischemia, rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, diabetes, osteoporosis, renal ischemia, cerebral stroke, cerebral ischemia, nephritis, inflammatory disorders of the lungs and gastrointestinal tract, reversible airway obstruction, chronic asthma or bronchitis comprising administering to a mammal in need of such treatment an effective amount of at least one compound of  claim 1 . 
   
   
       7 . A compound represented by the following structural formula: 
     
       
         
         
             
             
         
       
     
     or a pharmaceutically acceptable isomer, salt or solvate thereof. 
   
   
       8 . A compound represented by the following structural formula 
     
       
         
         
             
             
         
       
     
     or a pharmaceutically acceptable isomer, salt or solvate thereof. 
   
   
       9 . A compound represented by the following structural formula 
     
       
         
         
             
             
         
       
     
     or a pharmaceutically acceptable isomer, salt or solvate thereof. 
   
   
       10 . A compound represented by the following structural formula 
     
       
         
         
             
             
         
       
     
     or a pharmaceutically acceptable isomer, salt or solvate thereof. 
   
   
       11 . A compound represented by the following structural formula 
     
       
         
         
             
             
         
       
     
     or a pharmaceutically acceptable isomer, salt or solvate thereof. 
   
   
       12 . A compound represented by the following structural formula 
     
       
         
         
             
             
         
       
     
     or a pharmaceutically acceptable isomer, salt or solvate thereof. 
   
   
       13 . A compound represented by the following structural formula 
     
       
         
         
             
             
         
       
     
     or a pharmaceutically acceptable isomer, salt or solvate thereof. 
   
   
       14 . A compound represented by the following structural formula 
     
       
         
         
             
             
         
       
     
     or a pharmaceutically acceptable isomer, salt or solvate thereof. 
   
   
       15 . A compound represented by the following structural formula 
     
       
         
         
             
             
         
       
     
     or a pharmaceutically acceptable isomer, salt or solvate thereof. 
   
   
       16 . A compound represented by the following structural formula 
     
       
         
         
             
             
         
       
     
     or a pharmaceutically acceptable isomer, salt or solvate thereof.