Inflatable occlusion devices, methods, and systems

Abstract

Described are devices, methods and systems useful for achieving occlusion of vascular vessels. Percutaneous procedures can be used to occlude and obliterate the greater saphenous vein, for example in the treatment of varicose vein condition caused by venous reflux. Certain embodiments encompass the deployment and filling of an inflatable occlusion device via a percutaneous procedure, so as to occlude or obliterate a portion of a vascular vessel.

1 . A medical product comprising an occlusion balloon including a remodelable material. 
   
   
       2 . The medical product of  claim 1 , wherein the remodelable material comprises an extracellular matrix material. 
   
   
       3 . The medical product of  claim 2 , wherein the extracellular matrix material comprises submucosa, renal capsule membrane, dermal collagen, dura mater, pericardium, serosa, peritoneum, or basement membrane. 
   
   
       4 . The medical product of  claim 3 , wherein the submucosa comprises mammalian submucosa. 
   
   
       5 . The medical product of  claim 4 , wherein mammalian submucosa comprises porcine, bovine, or ovine submucosa material. 
   
   
       6 . The medical product of  claim 5 , wherein porcine submucosa comprises adult porcine submucosa. 
   
   
       7 . The medical product of  claim 1 , wherein the balloon comprises a single wall. 
   
   
       8 . The medical product of  claim 7 , wherein the balloon has a length of at least about 20 cm. 
   
   
       9 . The medical product of  claim 7 , wherein the balloon has a length of at least about 40 cm. 
   
   
       10 . An inflatable occlusion device for occluding a vascular vessel of a human, comprising:
 a balloon having a proximal end and a distal end, wherein the balloon has a length of at least about 10 cm, and wherein the balloon is configured for percutaneous delivery into the vascular vessel so as to cause occlusion of the vascular vessel.   
   
   
       11 . The inflatable occlusion device of  claim 10 , wherein the balloon includes a balloon wall formed from a remodelable extracellular matrix sheet material harvested from a biological tissue source, the remodelable extracellular matrix sheet material being effective to promote ingrowth of tissue of the patient into the remodelable extracellular matrix sheet material. 
   
   
       12 . The inflatable occlusion device of  claim 10  further comprising a delivery device having a lumen, wherein the balloon is removably positioned in the delivery device lumen and deployable from the lumen to the vascular vessel for causing occlusion of the vessel. 
   
   
       13 . The inflatable occlusion device of  claim 12  further comprising a wire guide positioned in the delivery device lumen. 
   
   
       14 . The inflatable occlusion device of  claim 13 , wherein the balloon is received over the wire guide. 
   
   
       15 . The inflatable occlusion device of  claim 14 , wherein the balloon has an opening in a wall of the balloon through which the wire guide extends. 
   
   
       16 . The inflatable occlusion device of  claim 10 , wherein the balloon includes a double walled balloon. 
   
   
       17 . The inflatable occlusion device of  claim 10 , further comprising a fill material for filling the balloon. 
   
   
       18 . The inflatable occlusion device of  claim 17 , wherein the fill material comprises, collagen, chitosan, oxidized regenerated cellulose, calcium alginate, alginate, or any suitable combination thereof. 
   
   
       19 . The inflatable occlusion device of  claim 17 , wherein the fill material comprises a remodelable extracellular matrix fill material effective to promote ingrowth of tissue of the patient into the remodelable extracellular matrix fill material. 
   
   
       20 . The inflatable occlusion device of  claim 19 , wherein the remodelable extracellular matrix fill material comprises a particulate remodelable extracellular matrix. 
   
   
       21 . A medical product, comprising:
 an inflatable occlusion device deployable within the vasculature of a patient; and   a fill material for filling the inflatable occlusion device, the fill material comprising a remodelable extracellular matrix material.   
   
   
       22 . The medical product of  claim 21 , wherein the remodelable extracellular matrix material comprises fluidized material.