US2009068737A1PendingUtilityA1
Methods of inhibiting interleukin-17 receptor
Est. expiryMar 23, 2015(expired)· nominal 20-yr term from priority
A61P 37/00A61P 37/06A61K 48/00C07K 2319/00A61P 29/00A61K 38/00C07K 14/54C07K 14/7155A61K 38/16C07K 14/715A61K 38/17C12N 15/11C12N 15/85
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Claims
Abstract
Isolated receptors for IL-17, DNA's encoding such receptors, and pharmaceutical compositions made therefrom, are disclosed. The isolated receptors can be used to regulate an immune response.
Claims
exact text as granted — not AI-modified1 . A method of interfering with Interleukin-17 binding an Interleukin-17 receptor, comprising contacting an antibody that specifically binds SEQ ID NO:10 to a cell expressing a polypeptide comprising SEQ ID NO:10 in the presence of IL-17, wherein said antibody binds said polypeptide and thereby interferes with Interleukin-17 binding to and activating said Interleukin-17 receptor.
2 . The method of claim 1 , wherein said antibody specifically binds the extracellular domain of SEQ ID NO:10.
3 . The method of claim 2 , wherein said antibody specifically binds amino acids 28 through 320 of SEQ ID NO:10.
4 . The method of claims 1 - 3 , wherein said antibody is a monoclonal antibody.Join the waitlist — get patent alerts
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