US2009068295A1PendingUtilityA1

Composition for treating cancer and method of using the same

55
Assignee: UNIV CHANG GUNGPriority: Sep 10, 2007Filed: Dec 12, 2007Published: Mar 12, 2009
Est. expirySep 10, 2027(~1.1 yrs left)· nominal 20-yr term from priority
Inventors:Jeng Wei
A61K 36/82A61K 31/495A61K 31/353A61K 45/06A61P 35/00
55
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Claims

Abstract

The present invention provides a composition, which includes an effective amount of DNA damaging agent and an effective amount of tea polyphenols. Particularly, the preferred DNA damaging agent is 5-Fluorouracil (5-FU), and the preferred tea polyphenols is Epigallocatechin gallate (EGCG).

Claims

exact text as granted — not AI-modified
1 . A composition, comprising:
 an effective amount of a DNA damaging agent; and   an effective amount of a tea polyphenols.   
   
   
       2 . The composition according to  claim 1 , wherein the DNA damaging agent is 5-Fluorouracil (5-FU). 
   
   
       3 . The composition according to  claim 1 , wherein the tea polyphenols are selected from a group consisting of Epigallocatechin gallate (EGCG), Epigallocatechin (EGC), Epicatechin gallate (ECG), and Epicatechin (EC). 
   
   
       4 . The composition according to  claim 3 , wherein the tea polyphenols is EGCG. 
   
   
       5 . The composition according to  claim 1 , further comprising a carrier which comprises Dimethyl sulfoxide (DMSO) or Dimethylformamide (DMF). 
   
   
       6 . The composition according to  claim 1 , further comprising Leucovorin. 
   
   
       7 . The composition according to  claim 1 , wherein the ratio of the DNA damaging agent to the tea polyphenols is in between 2% and 10%. 
   
   
       8 . The composition according to  claim 7 , wherein the ratio of the DNA damaging agent to the tea polyphenols is about 4%. 
   
   
       9 - 20 . (canceled) 
   
   
       21 . A composition for treating liver cancer, comprising:
 an effective amount of a DNA damaging agent; and   an effective amount of a tea polyphenols.   
   
   
       22 . The composition according to  claim 21 , wherein the DNA damaging agent is 5-Fluorouracil (5-FU). 
   
   
       23 . The composition according to  claim 21 , wherein the tea polyphenols are selected from a group consisting of Epigallocatechin gallate (EGCG), Epigallocatechin (EGC), Epicatechin gallate (ECG), and Epicatechin (EC). 
   
   
       24 . The composition according to  claim 23 , wherein the tea polyphenols is EGCG. 
   
   
       25 . The composition according to  claim 21 , further comprising a carrier which comprises Dimethyl sulfoxide (DMSO) or Dimethylformamide (DMF). 
   
   
       26 . The composition according to  claim 21 , further comprising Leucovorin. 
   
   
       27 . The composition according to  claim 21 , wherein the ratio of the DNA damaging agent to the tea polyphenols is in between 2% and 10%. 
   
   
       28 . The composition according to  claim 27 , wherein the ratio of the DNA damaging agent to the tea polyphenols is about  4 %. 
   
   
       29 . The composition of  claim 1  for treating leukemia. 
   
   
       30 . The composition according to  claim 29 , wherein the DNA damaging agent is 5-Fluorouracil (5-FU), the tea polyphenols is selected from the group consisting of Epigallocatechin gallate (EGCG), Epigallocatechin (EGC), Epicatechin gallate (ECG), and Epicatechin (EC); and further comprising a carrier which is Dimethyl sulfoxide (DMSO) or Dimethylformamide (DMF); and wherein the ratio of the DNA damaging agent to the tea polyphenols is in between 2% and 10%. 
   
   
       31 . The composition according to  claim 30 , further comprising Leucovorin. 
   
   
       32 . The composition according to  claim 30 , wherein the ratio of the DNA damaging agent to the tea polyphenols is about 4%.

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