Package of freeze Storage Container and Process for Producing the Same

Abstract

It is demanded that packages for cryopreservation containers which can prevent the conventional cryopreservation containers stored at very low temperatures, namely −80 to −196° C., from being damaged and are excellent in heat sealability be developed. The present invention provides a package for a cryopreservation container comprising at least an adhesive fluoropolymer film. The package for a cryopreservation container according to the invention makes it possible to store blood, rare cells and vital tissues in a very low temperature environment without any damage to the container. Further, the sealing strength resulting from heat sealing after placing a cryopreservation container in the packages is very good and, therefore, liquid nitrogen can be inhibited from entering the inside and thus contamination with bacteria, viruses or the like contained in liquid nitrogen can be avoided and the package can be prevented from being broken by expansion of intruder liquid nitrogen on the occasion of thawing.

1 . A package for a cryopreservation container comprising at least an adhesive fluoropolymer film. 
   
   
       2 . The package for a cryopreservation container according to  claim 1 ,
 wherein the adhesive fluoropolymer film is made of an adhesive fluoropolymer containing at least one adhesive site.   
   
   
       3 . The package for a cryopreservation container according to  claim 2 ,
 wherein the at least one adhesive site is selected from the group consisting of carbon-carbon double bond, carbonyl group [—C(═O)], carbonyl group-containing groups or bonds, hydroxyl group, cyano group, sulfonic acid group and epoxy group.   
   
   
       4 . The package for a cryopreservation container according to  claim 3 ,
 wherein the adhesive fluoropolymer contains at least one reactive functional group as the adhesive site and is a copolymer obtained by copolymerizing the following monomers (A) and (B):   (A) A fluorinated monomer containing no reactive functional group;   (B) A fluorinated monomer containing the at least one reactive functional group.   
   
   
       5 . The package for a cryopreservation container according to  claim 4 ,
 wherein the fluorinated monomer containing no reactive functional group is represented by the formula (1) given below:   
     
       
         
         
             
             
         
       
       (wherein X 1  and X 2  each is hydrogen atom or halogen atom and Y is hydrogen atom, fluorine atom, a fluorinated alkyl group containing 1 to 5 carbon atoms or a fluorinated oxyalkyl group containing 1 to 5 carbon atoms). 
     
   
   
       6 . The package for a cryopreservation container according to  claim 5 ,
 wherein the fluorinated monomer containing no reactive functional group comprises at least one monomer selected from the group consisting of tetrafluoroethylene, vinylidene fluoride, 1,2-difluorochloroethylene, hexafluoropropylene, perfluoro(vinyl methyl ether) and perfluoro(vinyl propyl ether).   
   
   
       7 . The package for a cryopreservation container according to  claim 4 ,
 wherein the fluorinated monomer containing the at least one reactive functional group is represented by the formula (2) given below:   
     
       
         
         
             
             
         
       
     
     (wherein X 1  and X 2  each is hydrogen atom or halogen atom, Z is hydroxyl group, carboxyl group, cyano group, sulfonic acid group or epoxy group and R f  is a fluorinated alkylene group containing 1 to 40 carbon atoms, a fluorinated oxyalkylene group containing 1 to 40 carbon atoms or a fluorinated alkylene group containing 1 to 40 carbon atoms and at least one ether bond). 
   
   
       8 . The package for a cryopreservation container according to  claim 4 ,
 wherein the adhesive fluoropolymer is represented by the formula (3) given below:   
     
       
         
         
             
             
         
       
     
     (wherein X 1  and X 2  each is hydrogen atom or halogen atom, Y 1  and Y 2  each is hydrogen atom, fluorine atom, a fluorinated alkyl group containing 1 to 5 carbon atoms or a fluorinated alkoxy group containing 1 to 5 carbon atoms, Z is hydroxyl group, carboxyl group, cyano group, sulfonic acid group or epoxy group, R f  is a fluorinated alkylene group containing 1 to 40 carbon atoms, a fluorinated oxyalkylene group containing 1 to 40 carbon atoms or a fluorinated alkylene group containing 1 to 40 carbon atoms and at least one ether bond and the ratio (1+m)/n is 2 to 2000). 
   
   
       9 . The package for a cryopreservation container according to  claim 3 ,
 wherein the adhesive fluoropolymer comprises a fluorinated monomer-derived fluorinated monomer unit and a nonfluorinated monomer-derived nonfluorinated monomer unit.   
   
   
       10 . The package for a cryopreservation container according to  claim 9 ,
 wherein the fluorinated monomer is tetrafluoroethylene and the nonfluorinated monomer is ethylene.   
   
   
       11 . The package for a cryopreservation container according to  claim 1  comprising:
 the adhesive fluoropolymer film on at least one outermost layer and a film other than said adhesive fluoropolymer film.   
   
   
       12 . The package for a cryopreservation container according to  claim 11 ,
 wherein the film other than the adhesive fluoropolymer film is a low-temperature resistant resin film.   
   
   
       13 . The package for a cryopreservation container according to  claim 12 ,
 wherein the low-temperature resistant resin comprises at least one resin selected from the group consisting of ultrahigh molecular weight polyethylene, polyimides, polytetrafluoroethylene, ethylene-tetrafluoroethylene copolymers and ethylene-vinyl acetate copolymers.   
   
   
       14 . The package for a cryopreservation container according to  claim 13 ,
 wherein the low-temperature resistant resin is a polyimide.   
   
   
       15 . A method of producing a package for a cryopreservation container comprising shaping an adhesive fluoropolymer film into a bag-like article by heat sealing. 
   
   
       16 . The method of producing a package for a cryopreservation container according to  claim 15 ,
 comprising shaping a laminated film comprising the adhesive fluoropolymer film on at least one outermost layer and a film other than said adhesive fluoropolymer film, into a bag-like article by heat sealing.