Compounds and methods of use

Abstract

Selected compounds are effective for treatment of pain and diseases, such as inflammation mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving pain, inflammation, and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

1 . A compound of Formula I′ 
     
       
         
         
             
             
         
       
     
     and pharmaceutically acceptable salts thereof, wherein
 R is chroman substituted with one to three basic moieties, and optionally substituted with one to three groups independently selected from the group consisting of halo, —NH 2 , —OH, —CN, —CF 3 , (C 1 -C 6 )alkylamino, oxo, (C 1 -C 6 )alkoxy, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, di(C 1 -C 6 )alkylamino, —C(O)R 8 , —COOR 8 , —C(O)NR 8 R 8′ , —NR 8 C(O)R 8 , (C 1 -C 6 )alkyl, aryl, heteroaryl, cycloalkyl and heterocyclyl, wherein the C 1 -C 6 )alkyl, aryl, heteroaryl, cycloalkyl and heterocyclyl groups are optionally substituted with one to three groups independently selected from the group consisting of halo, —NH 2 , —OH, —CN, —CF 3 , (C 1 -C 6 )alkylamino, halo(C 1 -C 6 )alkyl, oxo, (C 1 -C 6 )alkoxy, (C 1 -C 6 )alkoxy(C 1 -C 6 )alkyl, (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, di(C 1 -C 6 )alkylamino, —C(O)R 8 , —COOR 8 , —C(O)NR 8 R 8′ , and —NR 8 C(O)R 8′ ; 
 R 8  and R 8′  independently are selected from the group consisting of H, lower alkyl, aryl and heteroaryl, wherein the lower alkyl, aryl and heteroaryl groups are optionally substituted with one, two or three groups independently selected from the group consisting of lower alkyl, halogen, lower alkoxy, hydroxy, amino, mono- or dialkylamino, and trifluoromethyl; 
 R 1  is selected from the group consisting of 2,3-dihydro-benzo[1,4]dioxinyl, benzofuranyl, tetrahydro-quinolinyl, tetrahydro-isoquinolinyl, dihydrobenzofuranyl, benzothienyl, thienyl-CH 2 —, indolyl-CH 2 —, cycloalkyl, aryl, aryl-(CH 2 ) 0-2 —, heteroaryl and heterocyclyl, each of which is optionally substituted with one to five groups independently selected from the group consisting of halo, —NH 2 , —OH, —CN, —CF 3 , (C 1 -C 6 )alkylamino, halo(C 1 -C 6 )alkyl, oxo, (C 1 -C 6 )alkoxy, (C 1 -C 6 )alkoxy(C 1 -C 6 )alkyl, (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, di(C 1 -C 6 )alkylamino, —C(O)R 8 , —COOR 8 , —C(O)NR 8 R 8 , —NR 8 C(O)R 8′ , (C 2 -C 6 )alkyl, aryl, heteroaryl, cycloalkyl and heterocyclyl, wherein the (C 2 -C 6 )alkyl, aryl, heteroaryl, cycloalkyl and heterocyclyl groups are optionally substituted with one to three groups independently selected from the group consisting of halo, —NH 2 , —OH, —CN, —CF 3 , (C 1 -C 6 )alkylamino, halo(C 1 -C 6 )alkyl, oxo, (C 1 -C 6 )alkoxy, (C 1 -C 6 )alkoxy(C 1 -C 6 )alkyl, (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, di(C 1 -C 6 )alkylamino, —C(O)R 8 , —COOR 8 , —C(O)NR 8 R 8′ , and —NR 8 C(O)R 8′ ; 
 R 2  is selected from the group consisting of naphtho[2,3-d]dioxolyl, arylalkenyl, aryl, and heterocyclyl, wherein the heterocyclyl is selected from benzofuranyl, benzoxadiazolyl, benzothiadiazolyl, benzothiazolyl, 1H-pyrazolyl, thienyl, imidazolyl, isoxazolthienyl, benzothienyl, thieno[3,2-c]pyridinyl, pyridinyl, tetrahydroisoquinolinyl, quinolinyl, isoquinolinyl, and benzofused heteroaryl, wherein R 2  is optionally substituted with one to five groups independently selected from the group consisting of halo, —NH 2 , —OH, —CN, —CF 3 , (C 1 -C 6 )alkylamino, oxo, (C 1 -C 6 )alkoxy, haloalkoxy, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, di(C 1 -C 6 )alkylamino, —C(O)R 8 , —COOR 8 , —C(O)NR 8 R 8′ , —NR 8 C(O)R 8′ , (C 1 -C 6 )alkyl, aryl, heteroaryl, cycloalkyl and heterocyclyl, wherein the (C 1 -C 6 )alkyl, aryl, heteroaryl, cycloalkyl and heterocyclyl groups are optionally substituted with one to three groups independently selected from the group consisting of halo, —NH 2 , —OH, —CN, —CF 3 , (C 1 -C 6 )alkylamino, halo(C 1 -C 6 )alkyl, oxo, (C 1 -C 6 )alkoxy, (C 1 -C 6 )alkoxy(C 1 -C 6 )alkyl, (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, di(C 1 -C 6 )alkylamino, —C(O)R 8 , —COOR 8 , —C(O)NR 8 R 8′ , and —NR 8 C(O)R 8′ ; 
 each R a  is independently selected from the group consisting of H, aminocarbonylmethyl, C 1-4 -alkyl, and aryl, wherein the aryl group is optionally substituted with one to three groups selected from the group consisting of halo, —NH 2 , —OH, —CN, —CF 3 , (C 1 -C 6 ) alkylamino, halo(C 1 -C 6 ) alkyl, oxo, (C 1 -C 6 )alkoxy, (C 1 -C 6 )alkoxy(C 1 -C 6 )alkyl, (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, di(C 1 -C 6 )alkylamino, —C(O)R 8 , —COOR 8 , —C(O)NR 8 R 8′ , and —NR 8 C(O)R 8′ ; 
 the one to three basic moieties are independently selected from the group consisting of aminoalkyl, 7-aza-bicyclo[2.2.1]heptyl, 
 
     
       
         
         
             
             
         
       
        cycloalkylaminoalkyl, cycloalkylalkylaminoalkyl, heteroarylaminoalkyl, heteroarylalkylaminoalkyl, arylaminoalkyl, arylalkylaminoalkyl, alkoxyalkylaminoalkyl, hydroxyalkylaminoalkyl, alkenylalkylaminoalkyl, aminocarbonylalkylamino-alkyl, carboxyalkylaminoalkyl, C 1-6 -alkylamino-C 1-6 -alkoxy, C 1-6 -alkylamino-C 1-6 -alkoxy-C 1-6 -alkoxy, aminoalkoxy, aminoalkyl, alkylaminoalkyl, 5-6 membered heterocyclyloxy, 5-8 membered nitrogen-containing heterocyclyl, 5-8 membered nitrogen-containing heterocyclyl-alkyl, 5-7 membered nitrogen-containing heterocyclyl-alkylaminoalkyl, and NH 2 , wherein the basic moieties are optionally substituted with one to three groups independently selected from the group consisting of halo, —NH 2 , —OH, —CN, —CF 3 , (C 1 -C 6 ) alkylamino, halo(C 1 -C 6 ) alkyl, oxo, (C 1 -C 6 )alkoxy, (C 1 -C 6 )alkoxy(C 1 -C 6 )alkyl, (C 1 -C 6 )alkenyl, (C 1 -C 6 )alkynyl, di(C 1 -C 6 )alkylamino, —C(O)R™, —COOR 8 , —C(O)NR 8 R 8 , —NR 8 C(O)R 8′ , ═NCN, (C 1 -C 6 )alkyl, aryl, heteroaryl, cycloalkyl and heterocyclyl, wherein the (C 1 -C 6 )alkyl, aryl, heteroaryl, cycloalkyl and heterocyclyl groups are optionally substituted with one to three groups independently selected from halo, —NH 2 , —OH, —CN, —CF 3 , (C 1 -C 6 )alkylamino, haloalkyl, oxo, (C 1 -C 6 )alkoxy, (C 1 -C 6 )alkoxyalkyl, (C 1 -C 6 )alkyl, (C 1 -C 6 )alkenyl, (C 1 -C 6 )alkynyl, di(C 1 -C 6 )alkylamino, —C(O)R 8 , —COOR 8 , —C(O)NR 8 R 8′ , and —NR 8 C(O)R 8′ ; 
       R d  is selected from the group consisting of alkyl, cycloalkyl, cycloalkylalkyl, hydroxyalkyl, alkoxyalkyl, and H; and 
       R e  is H; or R d  and R e  together with the nitrogen atom to which they are attached form a heterocyclic ring; 
       provided the basic moiety is not phenylaminomethyl nor trifluomethylaminomethyl; and further provided R 1  is not 4-cyanophenyl. 
     
   
   
       2 . The compound of  claim 1  wherein
 R 1  is selected from the group consisting of C 5-6 cycloalkyl, phenyl, benzyl, naphthyl, benzo[1,3]dioxolyl, benzothiadiazolyl, thienyl-CH 2 —, indolyl-CH 2 —, benzoxadiazolyl, benzothienyl, 2,3-dihydro-benzo[1,4]dioxinyl, benzofuranyl, tetrahydro-quinolinyl, tetrahydro-isoquinolinyl, dihydrobenzofuranyl, thiazolyl, furanyl and thienyl; wherein R 1  is optionally substituted with one to five groups independently selected from the group consisting of halo, —NH 2 , —OH, —CN, —CF 3 , (C 1 -C 6 )alkylamino, halo(C 1 -C 6 )alkyl, oxo, (C 1 -C 6 )alkoxy, (C 1 -C 6 )alkoxy(C 1 -C 6 )alkyl, (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, di(C 1 -C 6 )alkylamino, —C(O)R 8 , —COOR 8 , —C(O)NR 8 R 8′ , —NR 8 C(O)R 8′ , (C 1 -C 6 )alkyl, aryl, heteroaryl, cycloalkyl and heterocyclyl, wherein the (C 1 -C 6 )alkyl, aryl, heteroaryl, cycloalkyl and heterocyclyl groups are optionally substituted with one to three groups independently selected from the group consisting of halo, —NH 2 , —OH, —CN, —CF 3 , (C 1 -C 6 )alkylamino, halo(C 1 -C 6 )alkyl, oxo, (C 1 -C 6 )alkoxy, (C 1 -C 6 )alkoxy(C 1 -C 6 )alkyl, (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, di(C 1 -C 6 )alkylamino, —C(O)R 8 , —COOR 8 , —C(O)NR 8 R 8′ , and —NR 8 C(O)R 8′ ;   R 2  is selected from the group consisting of phenyl-CH═CH—, tetrahydronaphthyl, naphtho[2,3-d]dioxolyl, benzofuranyl, benzoxadiazolyl, benzothiadiazolyl, benzothiazolyl, 1H-pyrazolyl, thienyl, isoxazolthienyl, benzothienyl, thieno[3,2-c]pyridinyl, naphthyl, phenyl, pyridinyl, tetrahydroisoquinolinyl, quinolinyl and isoquinolinyl; wherein R 2  is optionally substituted with one to five groups independently selected from the group consisting of halo, —NH 2 , —OH, —CN, —CF 3 , (C 1 -C 6 )alkylamino, oxo, (C 1 -C 6 )alkoxy, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, di(C 1 -C 6 )alkylamino, —C(O)R 8 , —COOR 8 , —C(O)NR 8 R 8′ , —NR 8 C(O)R 8′ , (C 1 -C 6 )alkyl, aryl, heteroaryl, cycloalkyl and heterocyclyl, wherein the (C 1 -C 6 )alkyl, aryl, heteroaryl, cycloalkyl and heterocyclyl groups are optionally substituted with one to three groups independently selected from the group consisting of halo, —NH 2 , —OH, —CN, —CF 3 , (C 1 -C 6 )alkylamino, halo(C 1 -C 6 )alkyl, oxo, (C 1 -C 6 )alkoxy, (C 1 -C 6 )alkoxy(C 1 -C 6 )alkyl, (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, di(C 1 -C 6 )alkylamino, —C(O)R 8 , —COOR 8 , —C(O)NR 8 R 8′ , and —NR 8 C(O)R 8′ ;   R a  is selected from the group consisting of H and C 1-2 -alkyl;   wherein the one to three basic moieties on R are independently selected from the group consisting of cycloalkylamino(C 1 -C 6 )alkyl, cycloalkyl(C 1 -C 6 )alkylamino(C 1 -C 6 )alkyl, heteroarylamino(C 1 -C 6 )alkyl,   
     
       
         
         
             
             
         
       
        heteroaryl(C 1 -C 6 )alkylamino(C 1 -C 6 )alkyl, arylamino(C 1 -C 6 )alkyl, alkoxyalkylaminoalkyl, hydroxyalkylaminoalkyl, alkenylalkylaminoalkyl, aminocarbonylalkylamino-alkyl, carboxyalkylaminoalkyl, aryl(C 1 -C 6 )alkylamino(C 1 -C 6 )alkyl, C 1-6 -alkylamino-C 1-6 -alkoxy, C 1-6 -alkylamino-C 1-6 -alkoxy-C 1-6 -alkoxy, haloalkylaminoalkyl, amino(C 1 -C 6 ) alkoxy, amino(C 1 -C 6 )alkyl, (C 1 -C 6 )alkylamino(C 1 -C 6 )alkyl, 5-6 membered heterocyclyloxy, 5-8 membered nitrogen-containing heterocyclyl, 5-7 membered nitrogen-containing heterocyclyl-alkylaminoalkyl, and 5-7 membered nitrogen-containing heterocyclyl-alkyl; wherein each of said basic moieties is optionally substituted with one to three groups independently selected from the group consisting of halo, —NH 2 , —OH, —CN, —CF 3 , (C 1 -C 6 )alkylamino, oxo, (C 1 -C 6 )alkoxy, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, di(C 1 -C 6 )alkylamino, —C(O)R 8 , —COOR 8 , —C(O)NR 8 R 8′ , —NR 8 C(O)R 8 , (C 1 -C 6 )alkyl, aryl, heteroaryl, cycloalkyl and heterocyclyl, wherein the (C 1 -C 6 )alkyl, aryl, heteroaryl, cycloalkyl or heterocyclyl groups are optionally substituted with one to three groups independently selected from the group consisting of halo, —NH 2 , —OH, —CN, —CF 3 , (C 1 -C 6 )alkylamino, halo(C 1 -C 6 )alkyl, oxo, (C 1 -C 6 )alkoxy, (C 1 -C 6 )alkoxy(C 1 -C 6 )alkyl, (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, di(C 1 -C 6 )alkylamino, —C(O)R 8 , —COOR 8 , —C(O)NR 8 R 8′ , and —NR 8 C(O)R 8 ; 
       R d  is selected from the group consisting of alkyl, cycloalkyl, cycloalkylalkyl, hydroxyalkyl, alkoxyalkyl, and H; and 
       R e  is H; or R d  and R e  together with the nitrogen atom to which they are attached form a heterocyclic ring; 
     
     and pharmaceutically acceptable salts thereof. 
   
   
       3 . The compound of  claim 2  wherein
 R 1  is selected from the group consisting of cyclohexyl, phenyl, benzyl, naphthyl, benzo[1,3]dioxolyl, 2,1,3-benzothiadiazol-5-yl, 2,1,3-benzoxadiazol-5-yl, benzothien-5-yl, 2,3-dihydro-benzo[1,4]dioxin-6-yl, benzofuranyl, tetrahydro-quinolinyl, tetrahydro-isoquinolinyl, dihydrobenzofuranyl, 1,3-thiazol-2-yl, thienyl-CH 2 —, indolyl-CH 2 —, furanyl, and thienyl; wherein R 1  is optionally substituted with one to five groups independently selected from the group consisting of halo, —NH 2 , —OH, —CN, —CF 3 , (C 1 -C 6 )alkylamino, halo(C 1 -C 6 )alkyl, oxo, (C 1 -C 6 )alkoxy, (C 1 -C 6 )alkoxy(C 1 -C 6 )alkyl, (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, di(C 1 -C 6 )alkylamino, —C(O)R 8 , —COOR 8 , —C(O)NR 8 R 8′ , —NR 8 C(O)R 8′ , (C 1 -C 6 )alkyl, aryl, heteroaryl, cycloalkyl and heterocyclyl, wherein the (C 1 -C 6 )alkyl, aryl, heteroaryl, cycloalkyl and heterocyclyl groups are optionally substituted with one to three groups independently selected from the group consisting of halo, —NH 2 , —OH, —CN, —CF 3 , (C 1 -C 6 )alkylamino, halo(C 1 -C 6 )alkyl, oxo, (C 1 -C 6 )alkoxy, (C 1 -C 6 )alkoxy(C 1 -C 6 )alkyl, (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, di(C 1 -C 6 )alkylamino, —C(O)R 8 , —COOR 8 , —C(O)NR 8 R 8′ , and —NR 8 C(O)R 8 ;   R 2  is selected from the group consisting of phenyl-CH═CH—, tetrahydronaphthyl, naphtho[2,3-d]dioxol-6-yl, 1-benzofur-2-yl, 2,1,3-benzoxadiazol-4-yl, 2,1,3-benzothiadiazol-4-yl, 1,3-benzothiazol-2-yl, 1H-pyrazol-4-yl, thien-2-yl, 5-isoxazolthien-2-yl, benzothien-2-yl, benzothien-3-yl, thieno[3,2-c]pyridin-2-yl, naphthyl, phenyl, 3-pyridyl, tetrahydroisoquinolyl, quinol-8-yl and isoquinolyl; wherein R 2  is optionally substituted with one to five groups independently selected from the group consisting of halo, —NH 2 , —OH, —CN, —CF 3 , (C 1 -C 6 )alkylamino, oxo, (C 1 -C 6 )alkoxy, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, di(C 1 -C 6 )alkylamino, —C(O)R 8 , —COOR 8 , —C(O)NR 8 R 8′ , —NR 3 C(O)R 8 , (C 1 -C 6 )alkyl, aryl, heteroaryl, cycloalkyl and heterocyclyl, wherein the (C 1 -C 6 )alkyl, aryl, heteroaryl, cycloalkyl and heterocyclyl group is optionally substituted with one to three groups independently selected from the group consisting of halo, —NH 2 , —OH, —CN, —CF 3 , (C 1 -C 6 )alkylamino, halo(C 1 -C 6 )alkyl, oxo, (C 1 -C 6 )alkoxy, (C 1 -C 6 )alkoxy(C 1 -C 6 )alkyl, (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, di(C 1 -C 6 )alkylamino, —C(O)R 8 , —COOR 8 , —C(O)NR 8 R 8′ , and —NR 8 C(O)R 8 ;   R a  is H or methyl;   wherein the basic moiety on R is selected from the group consisting of —NH 2 , aminoalkyl,   
     
       
         
         
             
             
         
       
        C 3-6 -cycloalkyl(C 1 -C 2 )alkylamino(C 1 -C 2 )alkyl, C 3-6 -cycloalkylamino(C 1 -C 2 ) alkyl, (C 1 -C 2 ) alkoxy(C 1 -C 2 )-alkylamino(C 1 -C 2 ) alkyl, mono-C 2-4 -alkenylamino-C 1-4 -alkyl, di-C 2-4 -alkenylamino-C 1-4 -alkyl, hydroxy-C 1-4 -alkyl-amino-C 1-4 -alkyl, aminocarbonyl-C 1-4 -alkylamino-C 1-2 -alkyl, mono-C 1-6 -alkylamino-C 1-4 -alkyl, di-C 1-4 -alkylamino-C 1-4 -alkyl, and 5-8 membered nitrogen-containing heterocyclyl-C 1-4 -alkyl, 
       R d  is selected from C 1-5 -alkyl, C 3-6 -cycloalkyl, C 3-6 -cycloalkyl-C 1-4 -alkyl, hydroxy-C 1-4 alkyl, C 1-3 -alkoxy-C 1-3 -alkyl and H; and 
       R e  is H; or R d  and R e  together with the nitrogen atom to which they are attached form a 4-8 membered nitrogen-containing heterocyclic ring; 
     
     and pharmaceutically acceptable salts thereof. 
   
   
       4 . The compound of  claim 1  wherein R a  is H; 
     and pharmaceutically acceptable salts thereof. 
   
   
       5 . The compound of  claim 1  wherein the basic moiety on R is selected from the group consisting of —NH 2 , aminomethyl, aminoethyl, aminopropyl, isopropylaminomethyl, t-butylaminomethyl, iso-butylaminomethyl, 1-methylpropylaminomethyl, 2-methylbutylaminomethyl, 2,2′-dimethylpropylaminomethyl, 2,2′,3-trimethylpropylaminomethyl, allyl-aminomethyl, isopropylaminopropyl, 1-(isobutylamino)ethyl, 1-(isopropyl-amino)-1-methylethyl, N-isopropyl-N-ethylaminomethyl, N-isopropyl-N-methylaminomethyl, N-t-butyl-N-methyl-aminomethyl, N-iso-butyl-N-methylaminomethyl, N-t-butyl-N-ethylaminomethyl, N-isobutyl-N-methylaminomethyl, N-t-butyl-N-isopropylylaminomethyl, N,N-di(isopropyl)-aminomethyl, N,N-dimethylaminomethyl, N,N-diethylamino-methyl, N,N-di(t-butyl)-aminomethyl, N,N-di(allyl)-aminomethyl, cyclopropylaminomethyl, 1-(cyclopropyl-amino)ethyl, cyclobutylaminomethyl, 2-(cyclobutyl-amino)ethyl, 1-(cyclobutylamino)ethyl, cyclopentylamino-methyl, 1-cyclopentylaminoethyl, cyclopropylmethyl-aminomethyl, hydroxyethylamino-allyl, isopropylamino-allyl, t-butylamino-allyl, cyclopropylmethylamino-allyl, piperidin-1-yl-allyl, pyrrolidin-1-yl-allyl, azetidin-1-yl-allyl, 3-hydroxypyrrolidin-1-yl-allyl, aminocarbonylethyl-aminomethyl, methoxyethylaminomethyl, 1-(methoxyethylamino)-ethyl, 1-piperidinylmethyl, 2-(piperidin-1-yl)ethyl, 4-fluoropiperidinylmethyl, 4,4′-difluoropiperidinylmethyl, 4-(piperidin-1-yl)-piperidinylmethyl, 3-aminocarbonylpiperidin-1-ylmethyl, 4-(dimethylamino)piperidin-1-ylmethyl, 2,6-dimethyl-piperidin-1-ylmethyl, 3,3-dimethylpiperidin-1-ylmethyl, piperidin-1-yl-2-methylethyl, 3-hydroxypiperidin-1-yl, 4-morpholinylmethyl, 4-morpholinylethyl, 1-pyrrolidinyl-methyl, 2-methylpyrrolidin-1-ylmethyl, 1-(methylpyrrolidin-1-yl)ethyl, 2,5-dimethylpyrrolidin-1-ylmethyl, 1-azetidinylmethyl, 7-aza-bicyclo[2.2.1]heptyl, piperazin-1-ylmethyl, 4-methylpiperazin-1-ylmethyl, and 1-pyrrolidinylethylaminomethyl; 
     and pharmaceutically acceptable salts thereof. 
   
   
       6 . A compound of formula II′ 
     
       
         
         
             
             
         
       
     
     and pharmaceutically acceptable salts thereof, wherein
 the C ring is tetrahydro-2H-pyran; 
 R′ is 
 
     
       
         
         
             
             
         
       
       R 1  is selected from the group consisting of cycloalkyl, aryl, heteroaryl and heterocyclyl, wherein the heterocyclyl group is selected from the group consisting of thienyl, imidazolyl, 2,1,3-benzothiadiazol-5-yl, 2,1,3-benzoxadiazol-5-yl, benzothien-5-yl, 2,3-dihydro- benzo[1,4]dioxin-6-yl, benzofuranyl, tetrahydro-quinolinyl, tetrahydro-isoquinolinyl, dihydrobenzofuranyl, and benzofused heteroaryl, wherein the cycloalkyl, aryl, heteroaryl, and heterocyclyl groups are optionally substituted with one to five groups independently selected from the group consisting of halo, —NH 2 , —OH, —CN, —CF 3 , (C 1 -C 6 )alkylamino, halo(C 1 -C 6 )alkyl, oxo, (C 1 -C 6 )alkoxy, haloalkoxy, (C 1 -C 6 )alkoxy(C 1 -C 6 )alkyl, (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, di(C 1 -C 6 )alkylamino, —C(O)R 8 , —COOR 8 , —C(O)NR 8 R 8′ , —NR 8 C(O)R 8′ , (C 1 -C 6 )alkyl, aryl, heteroaryl, cycloalkyl and heterocyclyl, wherein the (C 1 -C 6 )alkyl, aryl, heteroaryl, cycloalkyl and heterocyclyl groups are optionally substituted with one to three groups independently selected from halo, —NH 2 , —OH, —CN, —CF 3 , (C 1 -C 6 )alkylamino, halo(C 1 -C 6 )alkyl, oxo, (C 1 -C 6 )alkoxy, (C 1 -C 6 )alkoxy(C 1 -C 6 )alkyl, (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, di(C 1 -C 6 )alkylamino, —C(O)R 8 , —COOR 8 , —C(O)NR 8 R 8′ , and —NR 8 C(O)R 8′ ; 
       R 2  is selected from the group consisting of arylalkenyl, aryl, tetrahydronaphthyl, naphtho[2,3-d]dioxol-6-yl, benzofuranyl, benzoxadiazolyl, benzothiadiazolyl, benzothiazolyl, 1H-pyrazolyl, thienyl, imidazolyl, isoxazolthienyl, benzothienyl, thieno[3,2-c]pyridinyl, pyridinyl, tetrahydroisoquinolinyl, quinolinyl, isoquinolinyl, benzofused heteroaryl, and heterocyclyl, wherein R 2  is optionally substituted with one to five groups independently selected from the group consisting of halo, —NH 2 , —OH, —CN, —CF 3 , (C 1 -C 6 )alkylamino, oxo, (C 1 -C 6 )alkoxy, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, di(C 1 -C 6 )alkylamino, —C(O)R 8 , —COOR 8 , —C(O)NR 8 R 8′ , —NR 8 C(O)R 8′ , (C 1 -C 6 )alkyl, aryl, heteroaryl, cycloalkyl, and heterocyclyl, wherein the (C 1 -C 6 )alkyl, aryl, heteroaryl, cycloalkyl, and heterocyclyl groups are optionally substituted with one to three groups independently selected from the group consisting of halo, —NH 2 , —OH, —CN, —CF 3 , (C 1 -C 6 )alkylamino, halo(C 1 -C 6 )alkyl, oxo, (C 1 -C 6 )alkoxy, (C 1 -C 6 )alkoxy(C 1 -C 6 )alkyl, (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, di(C 1 -C 6 )alkylamino, —C(O)R 8 , —COOR 8 , —C(O)NR 8 R 8′ , and —NR 8 C(O)R 8′ ; 
       R a  is independently selected from the group consisting of H, C 1-4 -alkyl, and aryl, wherein the aryl group is optionally substituted with one to three groups selected from the group consisting of halo, —NH 2 , —OH, —CN, —CF 3 , (C 1 -C 6 )alkylamino, halo(C 1 -C 6 )alkyl, oxo, (C 1 -C 6 )alkoxy, (C 1 -C 6 )alkoxy- (C 1 -C 6 )alkyl, (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, di(C 1 -C 6 )alkylamino, —C(O)R 8 , —COOR 8 , —C(O)NR 8 R 8′ , and —NR 8 C(O)R 8′ ; 
       R 3 , R 4  and R 5  are independently H, halo, —NH 2 , —OH, —CN, —CF 3 , (C 1 -C 6 )alkylamino, oxo, (C 1 -C 6 )alkoxy, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, di(C 1 -C 6 )alkylamino, —C(O)R 8 , —COOR 8 , —C(O)NR 8 R 8′ , —NR C(O)R 8′ , a basic moiety, (C 1 -C 2 )alkyl, aryl, heteroaryl, cycloalkyl and heterocyclyl, wherein the (C 1 -C 2 )alkyl, aryl, heteroaryl, cycloalkyl, and heterocyclyl groups are optionally substituted with one to three groups independently selected from the group consisting of halo, —NH 2 , —OH, —CN, —CF 3 , (C 1 -C 6 )alkylamino, halo(C 1 -C 6 )alkyl, oxo, (C 1 -C 6 )alkoxy, (C 1 -C 6 )alkoxy(C 1 -C 6 )alkyl, (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, di(C 1 -C 6 )alkylamino, —C(O)R 8 , —COOR 8 , —C(O)NR 8 R 8′ , and —NR 8 C(O)R 8′ ; 
       R 8  and R 8′  independently are selected from the group consisting of H, lower alkyl, aryl, and heteroaryl, wherein the lower alkyl, aryl, and heteroaryl groups are optionally substituted with one, two or three groups independently selected from the group consisting of lower alkyl, halogen, lower alkoxy, hydroxy, amino, mono- or dialkylamino, and trifluoromethyl; 
       the basic moiety group is selected from the group consisting of aminoalkyl, 7-aza-bicyclo[2.2.1]heptyl, 
     
     
       
         
         
             
             
         
       
     
     cycloalkylaminoalkyl, cycloalkylalkylaminoalkyl, heteroarylaminoalkyl, heteroarylalkylaminoalkyl, arylaminoalkyl, arylalkylaminoalkyl, C 1-6 -alkylamino-C 1-6 -alkoxy, C 1-6 -alkylamino-C 1-6 -alkoxy-C 1-6 -alkoxy, aminoalkoxy, aminoalkyl, alkylaminoalkyl, 5-6 membered heterocyclyloxy, 5-8 membered nitrogen-containing heterocyclyl, 5-8 membered nitrogen-containing heterocyclyl-alkyl, 5-7 membered nitrogen-containing heterocyclyl-alkylaminoalkyl, and NH 2 , wherein the basic moieties are optionally substituted with one to three groups independently selected from the group consisting of halo, —NH 2 , —OH, —CN, —CF 3 , (C 1 -C 6 )alkylamino, halo(C 1 -C 6 )alkyl, oxo, (C 1 -C 6 )alkoxy, (C 1 -C 6 )alkoxy(C 1 -C 6 )alkyl, (C 1 -C 6 )alkenyl, (C 1 -C 6 )alkynyl, di(C 1 -C 6 )alkylamino, —C(O)R 8 , —COOR 8 , —C(O)NR 8 R 8′ , —NR 8 C(O)R 8′ , ═NCN, (C 1 -C 6 )alkyl, aryl, heteroaryl, cycloalkyl and heterocyclyl, wherein the (C 1 -C 6 )alkyl, aryl, heteroaryl, cycloalkyl and heterocyclyl groups are optionally substituted with one to three groups independently selected from halo, —NH 2 , —OH, —CN, —CF 3 , (C 1 -C 6 )alkylamino, haloalkyl, oxo, (C 1 -C 6 )alkoxy, (C 1 -C 6 )alkoxyalkyl, (C 1 -C 6 )alkyl, (C 1 -C 6 )alkenyl, (C 1 -C 6 )alkynyl, di(C 1 -C 6 )alkylamino, —C(O)R 8 , —COOR 8 , —C(O)NR 8 R 8 , and —NR 8 C(O)R 8′ ;
 R d  is selected from the group consisting of alkyl, cycloalkyl, cycloalkylalkyl, hydroxyalkyl, alkoxyalkyl, and H; and 
 R e  is H; or R d  and R e  together with the nitrogen atom to which they are attached form a heterocyclic ring; 
 provided at least one of R 3 , R 4  and R 5  is a basic moiety. 
 
   
   
       7 . The compound of  claim 6  wherein
 R 3  and R 5  are H; and   R 4  is selected from the group consisting of —NH 2 , aminomethyl, aminoethyl, aminopropyl, isopropylaminomethyl, t-butylaminomethyl, iso-butylaminomethyl, 1-methylpropylaminomethyl, 2-methylbutylaminomethyl, 2,2′-dimethylpropylaminomethyl, 2,2′,3-trimethylpropylaminomethyl, allyl-aminomethyl, isopropylaminopropyl, 1-(isobutylamino)ethyl, 1-(isopropylamino)-1-methylethyl, N-isopropyl- N-ethylaminomethyl, N-isopropyl-N-methylaminomethyl, N-t-butyl-N-methylaminomethyl, N-iso-butyl-N-methylaminomethyl, N-t-butyl-N-ethylaminomethyl, N-isobutyl-N-methylaminomethyl, N-t-butyl-N-isopropylylaminomethyl, N,N-di(isopropyl)aminomethyl, N,N-dimethylaminomethyl, N,N-diethylaminomethyl, N,N-di(t-butyl)-aminomethyl, N,N-di(allyl)-aminomethyl, cyclopropylaminomethyl, 1-(cyclopropylamino)ethyl, cyclobutylaminomethyl, 2-(cyclobutylamino)ethyl, 1-(cyclobutylamino)ethyl, cyclopentylaminomethyl, 1-cyclopentylaminoethyl, cyclopropylmethylaminomethyl, hydroxyethylamino-allyl, isopropylamino-allyl, t-butylamino-allyl, cyclopropyl methylamino-allyl, piperidin-1-yl-allyl, pyrrolidin-1-yl-allyl, azetidin-1-yl-allyl, 3-hydroxypyrrolidin-1-yl-allyl, aminocarbonylethylaminomethyl, methoxyethylaminomethyl, 1-(methoxyethylamino)ethyl, 1-piperidinylmethyl, 2-(piperidin-1-yl)ethyl, 4-fluoropiperidinylmethyl, 4,4′-difluoropiperidinylmethyl, 4-(piperidin-1-yl)piperidinylmethyl, 3-aminocarbonyl piperidin-1-ylmethyl, 4-(dimethylamino)piperidin-1-ylmethyl, 2,6-dimethylpiperidin-1-ylmethyl, 3,3-dimethylpiperidin-1-yl methyl, piperidin-1-yl-2-methylethyl, 3-hydroxypiperidin-1-yl, 4-morpholinylmethyl, 4-morpholinylethyl, 1-pyrrolidinyl methyl, 2-methylpyrrolidin-1-ylmethyl, 1-(methylpyrrolidin-1-yl)ethyl, 2,5-dimethylpyrrolidin-1-ylmethyl, 1-azetidinyl methyl, 7-aza-bicyclo[2.2.1]heptyl, piperazin-1-ylmethyl, 4-methylpiperazin-1-ylmethyl, and 1-pyrrolidinylethyl aminomethyl;   
     and pharmaceutically acceptable salts thereof. 
   
   
       8 . The compound of  claim 6  wherein
 R 4  and R 5  are H; and   R 3  is selected from the group consisting of —NH 2 , aminomethyl, aminoethyl, aminopropyl, isopropylaminomethyl, t-butylaminomethyl, iso-butylaminomethyl, 1-methylpropylaminomethyl, 2-methylbutylaminomethyl, 2,2′-dimethylpropylaminomethyl, 2,2′,3-trimethylpropylaminomethyl, allyl-aminomethyl, isopropylaminopropyl, 1-(isobutylamino)ethyl, 1-(isopropylamino)-1-methylethyl, N-isopropyl-N-ethylaminomethyl, N-isopropyl-N-methylaminomethyl, N-t-butyl-N-methylaminomethyl, N-iso-butyl-N-methyl-aminomethyl, N-t-butyl-N-ethylaminomethyl, N-isobutyl-N-methylaminomethyl, N-t-butyl-N-isopropylylaminomethyl, N,N-di(isopropyl)aminomethyl, N,N-dimethylaminomethyl, N,N-diethylaminomethyl, N,N-di(t-butyl)-aminomethyl, N,N-di(allyl)-aminomethyl, cyclopropyl-aminomethyl, 1-(cyclopropylamino)ethyl, cyclobutylamino-methyl, 2-(cyclobutylamino)ethyl, 1-(cyclobutylamino)ethyl, cyclopentylaminomethyl, 1-cyclopentylaminoethyl, cyclopropylmethylaminomethyl, hydroxyethylamino-allyl, isopropylamino-allyl, t-butylamino-allyl, cyclopropylmethyl-amino-allyl, piperidin-1-yl-allyl, pyrrolidin-1-yl-allyl, azetidin-1-yl-allyl, 3-hydroxypyrrolidin-1-yl-allyl, aminocarbonylethylaminomethyl, methoxyethylaminomethyl, 1-(methoxyethylamino)ethyl, 1-piperidinylmethyl, 2-(piperidin-1-yl)ethyl, 4-fluoropiperidinylmethyl, 4,4′-difluoropiperidinylmethyl, 4-(piperidin-1-yl)piperidinylmethyl, 3-aminocarbonyl-piperidin-1-ylmethyl, 4-(dimethylamino)piperidin-1-ylmethyl, 2,6-dimethylpiperidin-1-ylmethyl, 3,3-dimethyl-piperidin-1-ylmethyl, piperidin-1-yl-2-methylethyl, 3-hydroxypiperidin-1-yl, 4-morpholinylmethyl, 4-morpholinyl-ethyl, 1-pyrrolidinylmethyl, 2-methylpyrrolidin-1-ylmethyl, 1-(methylpyrrolidin-1-yl)ethyl, 2,5-dimethylpyrrolidin-1-yl-methyl, 1-azetidinylmethyl, 7-aza-bicyclo[2.2.1]heptyl, piperazin-1-ylmethyl, 4-methylpiperazin-1-ylmethyl, and 1-pyrrolidinylethylaminomethyl;   
     and pharmaceutically acceptable salts thereof. 
   
   
       9 . The compound of  claim 6  wherein
 R 3  and R 4  are H; and   R 5  is selected from the group consisting of —NH 2 , aminomethyl, aminoethyl, aminopropyl, isopropylaminomethyl, t-butylaminomethyl, iso-butylaminomethyl, 1-methylpropylaminomethyl, 2-methylbutylaminomethyl, 2,2′-dimethylpropylaminomethyl, 2,2′,3-trimethylpropylaminomethyl, allyl-aminomethyl, isopropylaminopropyl, 1-(isobutylamino)ethyl, 1-(isopropyl-amino)-1-methylethyl, N-isopropyl-N-ethylaminomethyl, N-isopropyl-N-methylaminomethyl, N-t-butyl-N-methylaminomethyl, N-iso-butyl-N-methylaminomethyl, N-t-butyl-N-ethylaminomethyl, N-isobutyl-N-methyl-aminomethyl, N-t-butyl-N-isopropylylaminomethyl, N,N-di(isopropyl)aminomethyl, N,N-dimethylaminomethyl, N,N-diethylaminomethyl, N,N-di(t-butyl)-aminomethyl, N,N-di(allyl)-aminomethyl, cyclopropylaminomethyl, 1-(cyclopropylamino)ethyl, cyclobutylaminomethyl, 2-(cyclobutylamino)ethyl, 1-(cyclobutylamino)ethyl, cyclopentylaminomethyl, 1-cyclopentylaminoethyl, cyclopropylmethylaminomethyl, hydroxyethylamino-allyl, isopropylamino-allyl, t-butylamino-allyl, cyclopropylmethylamino-allyl, piperidin-1-yl-allyl, pyrrolidin-1-yl-allyl, azetidin-1-yl-allyl, 3-hydroxypyrrolidin-1-yl-allyl, aminocarbonylethyl-aminomethyl, methoxyethylaminomethyl, 1-(methoxyethylamino)-ethyl, 1-piperidinylmethyl, 2-(piperidin-1-yl)ethyl, 4-fluoropiperidinylmethyl, 4,4′-difluoropiperidinylmethyl, 4-(piperidin-1-yl)-piperidinylmethyl, 3-aminocarbonylpiperidin-1-ylmethyl, 4-(dimethylamino)piperidin-1-ylmethyl, 2,6-dimethyl-piperidin-1-ylmethyl, 3,3-dimethylpiperidin-1-ylmethyl, piperidin-1-yl-2-methylethyl, 3-hydroxypiperidin-1-yl, 4-morpholinylmethyl, 4-morpholinylethyl, 1-pyrrolidinyl-methyl, 2-methylpyrrolidin-1-ylmethyl, 1-(methylpyrrolidin-1-yl)ethyl, 2,5-dimethylpyrrolidin-1-ylmethyl, 1-azetidinyl-methyl, 7-aza-bicyclo[2.2.1]heptyl, piperazin-1-ylmethyl, 4-methylpiperazin-1-ylmethyl, and 1-pyrrolidinylethyl-aminomethyl;   
     and pharmaceutically acceptable salts thereof. 
   
   
       10 . The compound of  claim 6  wherein the C ring is 
     
       
         
         
             
             
         
       
     
   
   
       11 . The compound of  claim 6  wherein
 R 1  is selected from the group consisting of cyclohexyl, phenyl, naphthyl, benzo[1,3]dioxolyl, 2,1,3-benzothiadiazol-5-yl, 2,1,3-benzoxadiazol-5-yl, benzothien-5-yl, 2,3-dihydro-benzo[1,4]dioxin-6-yl, benzofuranyl, tetrahydro-quinolinyl, tetrahydro-isoquinolinyl, dihydrobenzofuranyl, 1,3-thiazol-2-yl, furanyl, and thienyl; wherein R 1  is optionally substituted with one to five groups independently selected from the group consisting of halo, —NH 2 , —OH, —CN, —CF 3 , (C 1 -C 6 )alkylamino, haloalkyl, oxo, (C 1 -C 6 )alkoxy, (C 1 -C 6 )alkoxy(C 1 -C 6 )alkyl, (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, di(C 1 -C 6 )alkylamino, —C(O)R 8 , —COOR 8 , —C(O)NR 8 R 8′ , —NR 8 C(O)R 8′ , (C 1 -C 6 )alkyl, aryl, heteroaryl, cycloalkyl, and heterocyclyl, wherein the (C 1 -C 6 )alkyl, aryl, heteroaryl, cycloalkyl, and heterocyclyl groups are optionally substituted with one to three groups independently selected from the group consisting of halo, —NH 2 , —OH, —CN, —CF 3 , (C 1 -C 6 )alkylamino, halo(C 1 -C 6 )alkyl, oxo, (C 1 -C 6 )alkoxy, (C 1 -C 6 )alkoxy(C 1 -C 6 )alkyl, (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, di(C 1 -C 6 )alkylamino, —C(O)R 8 , —COOR 8 , —C(O)NR 8 R 8′ , and —NR 8 C(O)R 8′ .   
   
   
       12 . The compound of  claim 6  wherein
 R 2  is selected from the group consisting of phenyl-CH═CH, tetrahydronaphthyl, naphtho[2,3-d]dioxol-6-yl, 1-benzofuran-2-yl, 2,1,3-benzoxadiazol-4-yl, 2,1,3-benzothiadiazol-4-yl, 1,3-benzothiazol-2-yl, 1H-pyrazol-4-yl, thien-2-yl, 5-isoxazolthien-2-yl, benzothien-2-yl, benzothien-3-yl, thieno[3,2-c]pyridin-2-yl, naphthyl, phenyl, 3-pyridinyl, tetrahydroisoquinolinyl, quinolinyl and isoquinolinyl; wherein R 2  is optionally substituted with one or more groups selected from the group consisting of halo, —NH 2 , —OH, —CO 2 H, (C 1 -C 2 )alkylamino, (C 1 -C 2 )alkoxy, (C 1 -C 2 )alkoxy-(C 1 -C 2 )alkyl, (C 1 -C 2 )alkyl, halo(C 1 -C 2 )alkyl, di(C 1 -C 2 )alkylamino, and phenyl.   
   
   
       13 . The compound of  claim 6  wherein
 R 2  is selected from the group consisting of 2-naphthyl, 1-naphthyl, phenyl, 3-chlorophenyl, 4-chlorophenyl, 3,5-dichlorophenyl, 3,4-dichlorophenyl, 2,4,6-trichlorophenyl, 3-fluorophenyl, 3-methoxyphenyl, 4-methoxyphenyl, 3-biphenyl, 4′chlorophenyl-3-phenyl, 3-methylphenyl, 3-trifluoromethylphenyl, 2-chlorobenzothien-3-yl, and 3-pyridinyl; wherein R 2  is optionally substituted with one or more groups selected from the group consisting of halo, —NH 2 , —OH, —CO 2 H, (C 1 -C 2 )alkylamino, (C 1 -C 2 )alkoxy, (C 1 -C 2 )alkoxy-(C 1 -C 2 )alkyl, (C 1 -C 2 )alkyl, halo(C 1 -C 2 )alkyl, di(C 1 -C 2 )alkylamino, and phenyl.   
   
   
       14 . The compound of  claim 6  wherein R a  is H. 
   
   
       15 . The compound of  claim 6  wherein R 2  is 2-naphthyl. 
   
   
       16 . The compound of  claim 6  wherein R 2  is 3,4-dichlorophenyl or 3-trifluorophenyl. 
   
   
       17 . A compound selected from the group consisting of 
     N-Methyl-3-(R)-phenyl-N-(7-piperidin-1-ylmethyl-chroman-4-(R)-yl)-3-(3-trifluoromethyl-benzenesulfonylamino)-propionamide; 
     (3R)—N-((4R)-7-(2-(bis(2-methylpropyl)amino)ethyl)-3,4-dihydro-2H-chromen-4-yl)-3-phenyl-3-(((3-(trifluoromethyl)phenyl)sulfonyl)amino)propanamide; 
     N-[7-(2-Di-isobutylamino-ethyl)-chroman-4-yl]-3-phenyl-3-(3-trifluoromethylbenzenesulfonylamino)-propionamide; 
     (3R)—N-((4R)-7-(2-aminoethyl)-3,4-dihydro-2H-chromen-4-yl)-3-phenyl-3-(((3-(trifluoromethyl)-phenyl)sulfonyl)amino)-propanamide; 
     N-[7-(2-Aminoethyl)-chroman-4-yl]-3-phenyl-3-(3-trifluoromethylbenzenesulfonylamino)-propionamide; 
     (3R)—N-((4R)-7-(((1,1-Dimethylethyl)amino)methyl)-3,4-dihydro-2H-chromen-4-yl)-3-(((4-(1,1-dimethylethyl)phenyl)sulfonyl)amino)-3-phenylpropanamide; 
     (3R)-3-(((3-Chloro-4-methylphenyl)sulfonyl)amino)-N-((4R)-7-(((1,1-dimethylethyl)amino)methyl)-3,4-dihydro-2H-chromen-4-yl)-3-phenylpropanamide; 
     (3R)-3-(((3-Chloro-2-methylphenyl)sulfonyl)amino)-N-((4R)-7-(((1,1-dimethylethyl)amino)methyl)-3,4-dihydro-2H-chromen-4-yl)-3-phenylpropanamide; 
     (3S)-4-Phenyl-N-((4R)-7-(1-piperidinylmethyl)-3,4-dihydro-2H-chromen-4-yl)-3-(((3-(trifluoromethyl)phenyl)sulfonyl)amino)butanamide; 
     (3R)—N-((4R)-7-((4,4-Difluoro-1-piperidinyl)methyl)-3,4-dihydro-2H-chromen-4-yl)-3-phenyl-3-(((3-(trifluoromethyl)phenyl)sulfonyl)amino)propanamide; 
     (3R)—N-((4R)-7-((3,3-Difluoro-1-piperidinyl)methyl)-3,4-dihydro-2H-chromen-4-yl)-3-phenyl-3-(((3-(trifluoromethyl)phenyl)sulfonyl)amino)propanamide; 
     (3R)—N-((4R)-7-(7-Azabicyclo[2.2.1]hept-7-ylmethyl)-3,4-dihydro-2H-chromen-4-yl)-3-phenyl-3-(((3-(trifluoromethyl)phenyl)sulfonyl)amino)propanamide; 
     (3R)-3-(((5-Chloro-2,4-difluorophenyl)sulfonyl)amino)-N-((4R)-7-(((1,1-dimethylethyl)amino)methyl)-3,4-dihydro-2H-chromen-4-yl)-3-phenylpropanamide; 
     (3R)-3-(((2-Chloro-5-(trifluoromethyl)phenyl)sulfonyl)amino)-N-((4R)-7-(((1,1-dimethylethyl)amino)methyl)-3,4-dihydro-2H-chromen-4-yl)-3-phenylpropanamide; 
     (3R)—N-((4R)-7-(((1,1-Dimethylethyl)amino)methyl)-3,4-dihydro-2H-chromen-4-yl)-3-(((4-fluoro-3-(trifluoromethyl)phenyl)sulfonyl)amino)-3-phenylpropanamide; 
     (3R)-3-(((2,4-Dichlorophenyl)sulfonyl)amino)-N-((4R)-7-(((1,1-dimethylethyl)amino)methyl)-3,4-dihydro-2H-chromen-4-yl)-3-phenylpropanamide; 
     (3R)-3-(((3-Chloro-4-fluorophenyl)sulfonyl)amino)-N-((4R)-7-(((1,1-dimethylethyl)amino)methyl)-3,4-dihydro-2H-chromen-4-yl)-3-phenylpropanamide; 
     (3R)—N-((4R)-7-(((1,1-Dimethylethyl)amino)methyl)-3,4-dihydro-2H-chromen-4-yl)-3-phenyl-3-(((4-(trifluoromethyl)phenyl)sulfonyl)amino)propanamide 
     (3R)—N-((4R)-7-(((1,1-Dimethylethyl)amino)methyl)-3,4-dihydro-2H-chromen-4-yl)-3-phenyl-3-(((2-(trifluoromethyl)phenyl)sulfonyl)amino)propanamide; 
     (3R)-3-(((4-Chlorophenyl)sulfonyl)amino)-N-((4R)-7-(((1,1-dimethylethyl)amino)methyl)-3,4-dihydro-2H-chromen-4-yl)-3-phenylpropanamide; 
     (3R)-3-(((3-Chlorophenyl)sulfonyl)amino)-N-((4R)-7-(((1,1-dimethylethyl)amino)methyl)-3,4-dihydro-2H-chromen-4-yl)-3-phenylpropanamide; 
     (3R)-3-(((2-Chlorophenyl)sulfonyl)amino)-N-((4R)-7-(((1,1-dimethylethyl)amino)methyl)-3,4-dihydro-2H-chromen-4-yl)-3-phenylpropanamide; 
     (3R)—N-((4R)-7-((4-Fluoro-1-piperidinyl)methyl)-3,4-dihydro-2H-chromen-4-yl)-3-phenyl-3-(((3-(trifluoromethyl)phenyl)sulfonyl)amino)propanamide; 
     (3S)-3-(((3,4-Dichlorophenyl)sulfonyl)amino)-4-phenyl-N-((4R)-7-(1-piperidinylmethyl)-3,4-dihydro-2H-chromen-4-yl)butanamide; 
     (3R)—N-((4S)-7-(((1,1-dimethylethyl)amino)methyl)-3,4-dihydro-2H-chromen-4-yl)-3-((2-naphthalenylsulfonyl)amino)-3-phenylpropanamide; 
     (3R)—N-((4R)-7-(((1,1-Dimethylethyl)amino)methyl)-3,4-dihydro-2H-chromen-4-yl)-3-((2-naphthalenylsulfonyl)amino)-3-phenylpropanamide; 
     (3R)-3-(((3,4-Dichlorophenyl)sulfonyl)amino)-N-((4R)-7-(((1,1-dimethylethyl)amino)methyl)-3,4-dihydro-2H-chromen-4-yl)-3-phenylpropanamide; 
     (3R)—N-((4R)-7-(((1,1-Dimethylethyl)amino)methyl)-3,4-dihydro-2H-chromen-4-yl)-3-phenyl-3-(((3-(trifluoromethyl)phenyl)sulfonyl)amino)propanamide; 
     (3R)-3-(((3,4-Dichlorophenyl)sulfonyl)amino)-N-((4R)-7-(4-morpholinylmethyl)-3,4-dihydro-2H-chromen-4-yl)-3-phenylpropanamide; 
     (3R)-3-(((3,4-Dichlorophenyl)sulfonyl)amino)-3-phenyl-N-((4R)-7-(1-piperidinylmethyl)-3,4-dihydro-2H-chromen-4-yl)propanamide; 
     (3R)—N-((4R)-7-(4-Morpholinylmethyl)-3,4-dihydro-2H-chromen-4-yl)-3-phenyl-3-(((3-(trifluoromethyl)phenyl)sulfonyl)amino)propanamide; 
     (3R)-3-Phenyl-N-((4R)-7-(1-piperidinylmethyl)-3,4-dihydro-2H-chromen-4-yl)-3-(((3-(trifluoromethyl)phenyl)sulfonyl)amino)propanamide; 
     (3R)-3-phenyl-N-((4R)-7-((((2R)-tetrahydro-2-furanylmethyl)amino)-methyl)-3,4-dihydro-2H-chromen-4-yl)-3-(((3-(trifluoromethyl)phenyl)-sulfonyl)amino)propanamide; 
     N-(7-Cyclohexylaminomethyl-chroman-4-yl)-3-phenyl-3-(3-trifluoromethyl-benzenesulfonylamino)-propionamide; 
     N-[7-(sec-Butylamino-methyl)-chroman-4-yl]-3-phenyl-3-(3-trifluoromethyl-benzenesulfonylamino)-propionamide; 
     N-[7-(Isobutylamino-methyl)-chroman-4-yl]-3-phenyl-3-(3-trifluoromethyl-benzenesulfonylamino)-propionamide; 
     N-{7-[(2-Methyl-butylamino)-methyl]-chroman-4-yl}-3-phenyl-3-(3-trifluoromethyl-benzenesulfonylamino)-propionamide; 
     N-{7-[(2-Methoxy-ethylamino)-methyl]-chroman-4-yl}-3-phenyl-3-(3-trifluoromethyl-benzenesulfonylamino)-propionamide; 
     N-[7-(tert-Butylamino-methyl)-chroman-4-yl]-3-(3,5-dichloro-phenyl)-3-(3-trifluoromethyl-benzenesulfonylamino)-propionamide; 
     3-(3,5-Dichloro-phenyl)-N-(7-piperidin-1-ylmethyl-chroman-4-yl)-3-(3-trifluoromethyl-benzenesulfonylamino)-propionamide; 
     N-(7-Cyclopentylaminomethyl-chroman-4-yl)-3-(3,5-dichloro-phenyl)-3-(3-trifluoromethyl-benzenesulfonylamino)-propionamide; 
     3-(3,5-Dichloro-phenyl)-N-[7-(isobutylamino-methyl)-chroman-4-yl]-3-(3-trifluoromethyl-benzenesulfonylamino)-propionamide; 
     N-[7-(tert-Butylamino-methyl)-chroman-4-yl]-3-(4-cyano-phenyl)-3-(3-trifluoromethyl-benzenesulfonylamino)-propionamide; 
     N-[7-(tert-Butylamino-methyl)-6-chloro-chroman-4-yl]-3-phenyl-3-(3-trifluoromethyl-benzenesulfonylamino)-propionamide; 
     N-[7-(tert-Butylamino-methyl)-chroman-4-yl]-3-(3-fluoro-phenyl)-3-(3-trifluoromethyl-benzenesulfonylamino)-propionamide; 
     3-(3-Fluoro-phenyl)-N-(7-piperidin-1-ylmethyl-chroman-4-yl)-3-(3-trifluoromethyl-benzenesulfonylamino)-propionamide; 
     3-(3-Fluoro-phenyl)-N-{7-[(2-methoxy-ethylamino)-methyl]-chroman-4-yl}-3-(3-trifluoromethyl-benzenesulfonylamino)-propionamide; 
     N-(7-Cyclopentylaminomethyl-chroman-4-yl)-3-(3-fluoro-phenyl)-3-(3-trifluoromethyl-benzenesulfonylamino)-propionamide; 
     3-Phenyl-N-(7-pyrrolidin-1-ylmethyl-chroman-4-yl)-3-(3-trifluoromethyl-benzenesulfonylamino)-propionamide; 
     3-(4-Fluoro-phenyl)-N-{7-[(2-methoxy-ethylamino)-methyl]-chroman-4-yl}-3-(3-trifluoromethyl-benzenesulfonylamino)-propionamide; 
     3-(4-Fluoro-phenyl)-N-[7-(isopropylamino-methyl)-chroman-4-yl]-3-(3-trifluoromethyl-benzenesulfonylamino)-propionamide; 
     N-(7-Cyclobutylaminomethyl-chroman-4-yl)-3-(4-fluoro-phenyl)-3-(3-trifluoromethyl-benzenesulfonylamino)-propionamide; 
     N-[7-(tert-Butylamino-methyl)-chroman-4-yl]-3-(4-methyl-3-trifluoromethyl-benzenesulfonylamino)-3-phenyl-propionamide; 
     N-[7-(tert-Butylamino-methyl)-chroman-4-yl]-3-(4-chloro-3-trifluoromethyl-benzenesulfonylamino)-3-phenyl-propionamide; 
     (3S)-3-(3,5-dichlorophenyl)-N-((4R)-7-(((2,2-dimethylpropyl)amino)methyl)-3,4-dihydro-2H-chromen-4-yl)-3-(((3-(trifluoromethyl)phenyl)sulfonyl)amino)propanamide; 
     (3S)—N-((4R)-7-(((1,1-dimethylethyl)amino)methyl)-3,4-dihydro-2H-chromen-4-yl)-3-(4-fluorophenyl)-3-(((3-(trifluoromethyl)phenyl)sulfonyl)amino)propanamide; 
     (3R)-3-phenyl-N-((4S)-7-((2R)-2-piperidinyl)-3,4-dihydro-2H-chromen-4-yl)-3-(((3-(trifluoromethyl)phenyl)-sulfonyl)amino)propanamide; 
     (3R)—N-methyl-3-phenyl-N-((4R)-7-(1-piperidinylmethyl)-3,4-dihydro-2H-chromen-4-yl)-3-(((3-(trifluoromethyl)phenyl)-sulfonyl)amino)propanamide; 
     (3R)—N-((4R)-7-((cyclopropylamino)methyl)-3,4-dihydro-2H-chromen-4-yl)-3-phenyl-3-(((3-(trifluoromethyl)phenyl)-sulfonyl)amino)propanamide; 
     (3R)—N-((4R)-7-(((2-hydroxy-1,1-dimethylethyl)amino)methyl)-3,4-dihydro-2H-chromen-4-yl)-3-phenyl-3-(((3-(trifluoromethyl)phenyl)-sulfonyl)-amino)propanamide; 
     (3R)-3-phenyl-N-((4R)-7-((2-pyridinylamino)methyl)-3,4-dihydro-2H-chromen-4-yl)-3-(((3-(trifluoromethyl)phenyl)-sulfonyl)amino)propanamide; 
     (3R)—N-((4R)-7-(((3-hydroxy-2,2-dimethylpropyl)amino)methyl)-3,4-dihydro-2H-chromen-4-yl)-3-phenyl-3-(((3-(trifluoromethyl)phenyl)-sulfonyl)amino)propanamide; 
     (3R)-3-phenyl-N-((4R)-7-((((2S)-tetrahydro-2-furanylmethyl)amino)methyl)-3,4-dihydro-2H-chromen-4-yl)-3-(((3-(trifluoromethyl)phenyl)sulfonyl)-amino)propanamide; 
     (3R)—N-((4R)-7-((4-hydroxy-1-piperidinyl)methyl)-3,4-dihydro-2H-chromen-4-yl)-3-phenyl-3-(((3-(trifluoromethyl)phenyl)sulfonyl)-amino)propanamide; 
     3-(3,4-Dichloro-benzenesulfonylamino)-N-{7-[(2-methoxy-ethylamino)-methyl]-chroman-4-yl}-3-phenyl-propionamide; 
     (3R)—N-((4R)-7-(((1,1-dimethylethyl)amino)methyl)-3,4-dihydro-2H-chromen-4-yl)-3-(2-thienyl)-3-(((3-(trifluoromethyl)phenyl)sulfonyl)amino)propanamide; 
     (3R)—N-((4R)-7-((cyclobutylamino)methyl)-3,4-dihydro-2H-chromen-4-yl)-3-phenyl-3-(((3-(trifluoromethyl)phenyl)sulfonyl)amino)propanamide; 
     (3R)—N-((4R)-7-(((3R)-3-hydroxy-1-piperidinyl)methyl)-3,4-dihydro-2H-chromen-4-yl)-3-phenyl-3-(((3-(trifluoromethyl)phenyl)sulfonyl)amino)-propanamide; 
     (3R)—N-((4R)-7-(((cyclopropylmethyl)amino)methyl)-3,4-dihydro-2H-chromen-4-yl)-3-phenyl-3-(((3-(trifluoromethyl)phenyl)sulfonyl)amino)propanamide; 
     (3R)-3-(((3,4-dichlorophenyl)sulfonyl)amino)-N-((4R)-7-(((1,1-dimethylethyl)amino)methyl)-3,4-dihydro-2H-chromen-4-yl)-3-phenylpropanamide; 
     3-(Naphthalen-2-yl-sulfonylamino)-3-(R)-phenyl-N—(R)-(7-piperidin-1-ylmethyl-chroman-4-yl)-propionamide; 
     3-(Naphthalen-2-yl-sulfonylamino)-3-phenyl-N-(6-piperidin-1-ylmethyl-chroman-4-yl)-propionamide hydrochloride; 
     3-(naphthalen-2-yl-sulfonylamino)-3-phenyl-N-(8-piperidin-1-ylmethyl-chroman-4-yl)-propionamide; 
     3-(Naphthalen-2-yl-sulfonylamino)-3-phenyl-N-(8-piperidin-1-ylmethyl-chroman-4-yl)-propionamide hydrochloride; 
     N-{7-[(Cyclopentyl-methyl-amino)-methyl]-chroman-4-yl}-3-(naphthalen-2-yl-sulfonylamino)-3-phenyl-propionamide; 
     N-(7-Diethylaminomethyl-chroman-4-yl)-3-(naphthalen-2-yl-sulfonylamino)-3-phenyl-propionamide; 
     N-(7-Dimethylaminomethyl-chroman-4-yl)-3-(naphthalen-2-yl-sulfonylamino)-3-phenyl-propionamide; 
     N-(7-Morpholin-4-ylmethyl-chroman-4-yl)-3-(naphthalen-2-yl-sulfonylamino)-3-phenyl-propionamide; 
     N-[7-(tert-Butylamino-methyl)-chroman-4-yl]-3-(naphthalen-2-yl-sulfonylamino)-3-phenyl-propionamide; 
     N-[7-(2R,5R-Dimethyl-pyrrolidin-1-ylmethyl)-chroman-4-yl]-3-(naphthalen-2-yl-sulfonylamino)-3-phenyl-propionamide; 
     N-{7-[(Diisopropylamino)-methyl]-chroman-4-yl}-3-(naphthalen-2-yl-sulfonylamino)-3-phenyl-propionamide; 
     N-{7-[(tert-Butyl-ethyl-amino)-methyl]-chroman-4-yl}-3-(naphthalen-2-yl-sulfonylamino)-3-phenyl-propionamide; 
     N-{7-[(tert-Butyl-methyl-amino)-methyl]-chroman-4-yl}-3-(naphthalen-2-yl-sulfonylamino)-3-phenyl-propionamide; 
     N-{7-[(isobutyl-methyl-amino)-methyl]-chroman-4-yl}-3-(naphthalen-2-yl-sulfonylamino)-3-phenyl-propionamide; 
     N-{7-[(ethyl-isopropyl-amino)-methyl]-chroman-4-yl}-3-(naphthalen-2-yl-sulfonylamino)-3-phenyl-propionamide; 
     N-{7-[(isopropyl-methyl-amino)-methyl]-chroman-4-yl}-3-(naphthalen-2-yl-sulfonylamino)-3-phenyl-propionamide; 
     N-{7-[(tert-Butyl-isopropyl-amino)-methyl]-chroman-4-yl}-3-(naphthalen-2-yl-sulfonylamino)-3-phenyl-propionamide; 
     N-[7-(Isopropylamino-methyl)-chroman-4-yl]-3-(naphthalen-2-ylsulfonylamino)-3-phenyl-propionamide; 
     N-(7-Aminomethyl-chroman-4-yl)-3-(naphthalen-2-ylsulfonylamino)-3-phenyl-propionamide; 
     3-(3,5-Dichloro-benzenesulfonylamino)-3-phenyl-N-(7-piperidin-1-ylmethyl-chroman-4-yl)-propionamide; 
     3-(3,4-Dichloro-benzenesulfonylamino)-N-[7-(4-methyl-piperazin-1-ylmethyl)-chroman-4-yl]-3-phenyl-propionamide; 
     3-Phenyl-N-(7-piperidin-1-ylmethyl-chroman-4-yl)-3-(3-trifluoromethyl-benzenesulfonylamino)-propionamide; 
     3-(Naphthalen-2-ylsulfonylamino)-3-phenyl-N-(7-pyrrolidin-1-ylmethyl-chroman-4-yl)-propionamide; 
     N-[7-(4-Dimethylamino-piperidin-1-ylmethyl)-chroman-4-yl]-3-(naphthalen-2-ylsulfonylamino)-3-phenyl-propionamide; 
     N-(7-[1,4′]Bipiperidinyl-1′-ylmethyl-chroman-4-yl)-3-(naphthalen-2-ylsulfonylamino)-3-phenyl-propionamide; 
     N-[7-(4-Methyl-piperazin-1-ylmethyl)-chroman-4-yl]-3-(naphthyl-2-ylsulfonylamino)-3-phenyl-propionamide; 
     3-(Naphthalen-2-ylsulfonylamino)-3-phenyl-N-(7-piperidin-1-ylmethyl-chroman-4-yl)-propionamide; 
     3-(3,4-Dichloro-benzenesulfonylamino)-3-phenyl-N-(7-piperidin-1-ylmethyl-chroman-4-yl)-propionamide; 
     3-(3,4-Dichloro-benzenesulfonylamino)-3-(4-fluoro-phenyl)-N-(7-piperidin-1-ylmethyl-chroman-4-yl)-propionamide; 
     3-(4-Fluoro-phenyl)-N-(7-piperidin-1-ylmethyl-chroman-4-yl)-3-(3-trifluoromethyl-benzenesulfonylamino)-propionamide; 
     3-(3,4-Dichloro-benzenesulfonylamino)-3-(4-fluoro-phenyl)-N-{7-[(2-methoxy-ethylamino)-methyl]-chroman-4-yl}-propionamide; 
     N-[7-(tert-Butylamino-methyl)-chroman-4-yl]-3-(3,4-dichloro-benzenesulfonylamino)-3-(4-fluoro-phenyl)-propionamide; 
     3-(4-Fluoro-phenyl)-N-[7-(isobutylamino-methyl)-chroman-4-yl]-3-(3-trifluoromethyl-benzenesulfonylamino)-propionamide; 
     N-[7-(tert-Butylamino-methyl)-chroman-4-yl]-3-(4-fluoro-phenyl)-3-(3-trifluoromethyl-benzenesulfonylamino)-propionamide; 
     3-(4-Fluoro-phenyl)-N-(7-pyrrolidin-1-ylmethyl-chroman-4-yl)-3-(3-trifluoromethyl-benzenesulfonylamino)-propionamide; 
     N-[7-(tert-Butylamino-methyl)-6-chloro-chroman-4-yl]-3-(4-fluoro-phenyl)-3-(3-trifluoromethyl-benzenesulfonylamino)-propionamide; 
     N-{7-[(Cyclopropylmethyl-amino)-methyl]-chroman-4-yl}-3-(4-fluoro-phenyl)-3-(3-trifluoromethyl-benzenesulfonylamino)-propionamide; 
     N-[7-(tert-Butylamino-methyl)-chroman-4-yl]-3-(2-chloro-5-trifluoromethyl-benzenesulfonylamino)-3-(4-fluoro-phenyl)-propionamide; 
     (3R)-3-Phenyl-N-((4R)-7-(1-piperidinylmethyl)-3,4-dihydro-2H-chromen-4-yl)-3-(((3-(trifluoromethyl)phenyl)sulfonyl)amino)propanamide; 
     (3R)-3-(((3,4-Dichlorophenyl)sulfonyl)amino)-3-phenyl-N-((4R)-7-(1-piperidinylmethyl)-3,4-dihydro-2H-chromen-4-yl)propanamide; 
     (3R)-3-(((3,4-Dichlorophenyl)sulfonyl)amino)-N-((4R)-7-(4-morpholinylmethyl)-3,4-dihydro-2H-chromen-4-yl)-3-phenylpropanamide; 
     (3R)—N-((4R)-7-(((1,1-Dimethylethyl)amino)methyl)-3,4-dihydro-2H-chromen-4-yl)-3-phenyl-3-(((3-(trifluoromethyl)phenyl)sulfonyl)amino)propanamide; 
     (3R)—N-((4R)-7-((4-Fluoro-1-piperidinyl)methyl)-3,4-dihydro-2H-chromen-4-yl)-3-phenyl-3-(((3-(trifluoromethyl)phenyl)sulfonyl)amino)propanamide; and 
     (3R)—N-((4R)-7-((4,4-Difluoro-1-piperidinyl)methyl)-3,4-dihydro-2H-chromen-4-yl)-3-phenyl-3-(((3-(trifluoromethyl)phenyl)sulfonyl)amino)propanamide; 
     or a pharmaceutically acceptable salt thereof. 
   
   
       18 . A compound of Formula III′ 
     
       
         
         
             
             
         
       
     
     and pharmaceutically acceptable salts thereof wherein
 R 2  is selected from the group consisting of naphthyl, phenyl, pyridinyl, quinolinyl and isoquinolinyl, wherein the naphthyl, phenyl, pyridinyl, quinolinyl and isoquinolinyl groups are optionally substituted with one to three substituents selected from the group consisting of chloro, fluoro, methoxy, methyl, trifluoromethyl, and phenyl; 
 R 6  is selected from the group consisting of H, halo, phenyl, methyl, methoxy and —CF 3 ; 
 R 7  is selected from the group consisting of aminoalkyl, 7-aza-bicyclo[2.2.1]heptyl, 
 
     
       
         
         
             
             
         
       
        C 3-6 -cycloalkyl(C 1 -C 2 ) alkylamino(C 1 -C 2 )alkyl, C 3-6 -cycloalkylamino(C 1 -C 2 )alkyl, (C 1 -C 2 )alkoxy(C 1 -C 2 )alkylamino(C 1 -C 2 )alkyl, mono-C 2-4 -alkenyl-amino-C 1-4 -alkyl, di-C 2-4 -alkenylamino-C 1-4 -alkyl, hydroxy-C 1-4 -alkylamino-C 1-4 -alkyl, aminocarbonyl-C 1-4 -alkyl-amino-C 1-2 -alkyl, mono-C 1-6 -alkylamino-C 1-4 -alkyl, di-C 1-4 -alkylamino-C 1-4 -alkyl, and 5-8 membered heterocyclyl-C 1-2 -alkyl; wherein the 5-8 membered heterocyclyl-C 1-2 -alkyl is optionally substituted with one to three groups independently selected from the group consisting of halo, —NH 2 , —OH, —CN, —CF 3 , (C 1 -C 6 )alkylamino, oxo, (C 1 -C 6 )alkoxy, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, di(C 1 -C 6 )alkylamino, —C(O)R 8 , —COOR 8 , —C(O)NR 8 R 8′ , —NR 8 C(O)R 8 , and ═NCN; wherein R 7  is at position 6, 7 or 8; 
       R d  is selected from the group consisting of C 1-5 -alkyl, C 3-6 -cycloalkyl, C 3-6 -cycloalkyl-C 1-4 -alkyl, C 1-4 -hydroxyalkyl, C 1-3 -alkoxy-C 1-3 -alkyl and H; 
       R e  is H; or R d  and R e  together with the nitrogen atom to which they are attached form form a 4-8 membered nitrogen-containing heterocyclic ring; and 
       R 8  and R 8′  independently are selected from the group consisting of H, lower alkyl, aryl and heteroaryl, wherein the lower alkyl, aryl and heteroaryl groups are optionally substituted with one, two or three groups independently selected from the group consisting of lower alkyl, halogen, lower alkoxy, hydroxy, amino, mono- or dialkylamino, and trifluoromethyl. 
     
   
   
       19 . The compound according to  claim 18  wherein
 R 7  is selected from the group consisting of aminomethyl, aminoethyl, aminopropyl, isopropylaminomethyl, t-butylaminomethyl, iso-butylaminomethyl, 1-methylpropylaminomethyl, 2-methylbutylaminomethyl, 2,2′-dimethylpropylaminomethyl, 2,2′,3-trimethylpropylaminomethyl, allyl-aminomethyl, isopropylaminopropyl, 1-(isobutylamino)ethyl, 1-(isopropyl-amino)-1-methylethyl, N-isopropyl-N-ethylaminomethyl, N-isopropyl-N-methylaminomethyl, N-t-butyl-N-methyl-aminomethyl, N-iso-butyl-N-methylaminomethyl, N-t-butyl-N-ethylaminomethyl, N-isobutyl-N-methylaminomethyl, N-t-butyl-N-isopropylylaminomethyl, N,N-di(isopropyl)-aminomethyl, N,N-dimethylaminomethyl, N,N-diethylamino-methyl, N,N-di(t-butyl)-aminomethyl, N,N-di(allyl)-aminomethyl, cyclopropylaminomethyl, 1-(cyclopropylamino)-ethyl, cyclobutylaminomethyl, 2-(cyclobutylamino)ethyl, 1-(cyclobutylamino)ethyl, cyclopentylaminomethyl, 1-cyclopentylaminoethyl, cyclopropylmethylaminomethyl, hydroxyethylamino-allyl, isopropylamino-allyl, t-butylamino-allyl, cyclopropylmethylamino-allyl, piperidin-1-yl-allyl, pyrrolidin-1-yl-allyl, azetidin-1-yl-allyl, 3-hydroxypyrrolidin-1-yl-allyl, aminocarbonylethyl-aminomethyl, methoxyethylaminomethyl, 1-(methoxyethylamino)ethyl, 1-piperidinylmethyl, 2-(piperidin-1-yl)ethyl, 4-fluoropiperidinylmethyl, 4,4′-difluoropiperidinylmethyl, 4-(piperidin-1-yl)piperidinylmethyl, 3-aminocarbonyl-piperidin-1-ylmethyl, 4-(dimethylamino)piperidin-1-ylmethyl, 2,6-dimethylpiperidin-1-ylmethyl, 3,3-dimethyl-piperidin-1-ylmethyl, piperidin-1-yl-2-methylethyl, 3-hydroxypiperidin-1-yl, 4-morpholinylmethyl, 4-morpholinyl-ethyl, 1-pyrrolidinylmethyl, 2-methylpyrrolidin-1-ylmethyl, 1-(methylpyrrolidin-1-yl)ethyl, 2,5-dimethylpyrrolidin-1-yl-methyl, 1-azetidinylmethyl, 7-aza-bicyclo[2.2.1]heptyl, piperazin-1-ylmethyl, 4-methylpiperazin-1-ylmethyl, and 1-pyrrolidinylethylaminomethyl;   
     and pharmaceutically acceptable salts thereof. 
   
   
       20 . The compound according to  claim 18  wherein R 7  is substituted at position 7. 
   
   
       21 . The compound according to  claim 18  wherein R 2  is 2-naphthyl, 3,4-dichlorophenyl or 3-trifluoromethylphenyl. 
   
   
       22 . The compound according to  claim 18  wherein R 6  is H. 
   
   
       23 . A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a compound of  claim 1 . 
   
   
       24 . The pharmaceutical composition of  claim 23  further comprising one or more other pharmacologically active ingredients. 
   
   
       25 . A method for the treatment of disease conditions mediated by bradykinin, in a mammalian subject, which comprises administering a therapeutically effective amount of a compound according to claim and a pharmaceutically acceptable carrier. 
   
   
       26 . The method according to  claim 25  wherein the disease or condition is selected from the group consisting of inflammation, rheumatoid arthritis, cystitis, post-traumatic and post ischemic cerebral edema, liver cirrhosis, Alzheimer's disease, cardiovascular disease, pain, common cold, allergies, asthma, pancreatitis, burns, virus infection, head injury, multiple trauma, rhinitis, hepatorenal failure, diabetes, metastasis, pancreatitis, neovascularization, corneal haze, glaucoma, ocular pain, ocular hypertension and angio edema. 
   
   
       27 . A compound selected from the group consisting of 
     3-Phenyl-N-(7-cyclopentylaminomethylchroman-4-yl)-3-(3-trifluoromethylbenzenesulfonylamino)propionamide; 
     3-Phenyl-N-(7-cyclopentylaminomethylchroman-4-yl)-3-(3-trifluoromethylbenzenesulfonylamino)propionamide; 
     3-Phenyl-N-(7-(2,2,2-trifluoroethylaminomethyl)chroman-4-yl)-3-(3-trifluoromethylbenzenesulfonylamino)propionamide; 
     3-Phenyl-N-(7-(2-methylbutylaminomethyl)chroman-4-yl)-3-(3-trifluoromethylbenzenesulfonylamino)propionamide; 
     3-Phenyl-N-(7-(2-methoxyethylaminomethyl)chroman-4-yl)-3-(3-trifluoromethylbenzenesulfonylamino)propionamide; 
     3-Phenyl-N-(7-allylaminomethylchroman-4-yl)-3-(3-trifluoromethylbenzenesulfonylamino)propionamide; 
     3-Phenyl-N-(7-(2,5-dihydro-pyrrol-1-ylmethyl)chroman-4-yl)-3-(3-trifluoromethylbenzenesulfonylamino)propionamide; 
     3-Phenyl-N-(7-(3-carbamoylpiperidin-1-ylmethyl)chroman-4-yl)-3-(3-trifluoromethylbenzenesulfonylamino)propionamide; 
     3-Phenyl-N-(7-(3-hydroxypiperidin-1-ylmethyl)chroman-4-yl)-3-(3-trifluoromethylbenzenesulfonylamino)propionamide; 
     3-Phenyl-N-(7-(allylbut-3-enylamino)methylchroman-4-yl)-3-(3-trifluoromethylbenzenesulfonylamino)propionamide; 
     3-Phenyl-N-(7-(3,6-dihydro-2H-pyridin-1-ylmethyl)chroman-4-yl)-3-(3-trifluoromethylbenzenesulfonylamino)propionamide; 
     3-Phenyl-N-(7-(3-methylbutylaminomethyl)chroman-4-yl)-3-(3-trifluoromethylbenzenesulfonylamino)propionamide; 
     3-Phenyl-N-(7-phenylaminomethylchroman-4-yl)-3-(3-trifluoromethylbenzenesulfonylamino)propionamide; 
     3-Phenyl-N-(7-tetrahydrofuran-2-ylmethylaminomethylchroman-4-yl)-3-(3-trifluoromethylbenzenesulfonylamino)propionamide; 
     3-Phenyl-N-(7-tert-butylaminomethylchroman-4-yl)-3-(3-trifluoromethylbenzenesulfonylamino)propionamide; 
     3-Phenyl-N-(7-cyclobutylaminomethylchroman-4-yl)-3-(3-trifluoromethylbenzenesulfonylamino)propionamide; 
     3-Phenyl-N-(7-cyclopropylmethylaminomethylchroman-4-yl)-3-(3-trifluoromethylbenzenesulfonylamino)propionamide; 
     3-(Naphthalen-2-ylsulfonylamino)-N,3-diphenyl-N-(6-(2-piperazin-1-ylethyl)chroman-4-yl)-propionamide; 
     3-(Naphthalen-2-ylsulfonylamino)-N,3-diphenyl-N-(6-(2-methylethylaminoethyl)chroman-4-yl)-propionamide; 
     3-(Naphthalen-2-ylsulfonylamino)-N,3-diphenyl-N-(6-diethylaminomethylchroman-4-yl)-propionamide; 
     3-(Naphthalen-2-ylsulfonylamino)-N,3-diphenyl-N-(6-(4-methylpiperazin-1-ylmethyl)chroman-4-yl)-propionamide; 
     3-(Naphthalen-2-ylsulfonylamino)-N,3-diphenyl-N-(6-piperazin-1-ylmethylchroman-4-yl)-propionamide; 
     3-(Naphthalen-2-ylsulfonylamino)-N,3-diphenyl-N-(6-dimethylaminomethylchroman-4-yl)-propionamide; 
     3-(Naphthalen-2-ylsulfonylamino)-N,3-diphenyl-N-(6-piperidin-1-ylmethylchroman-4-yl)-propionamide; 
     3-(Naphthalen-2-ylsulfonylamino)-3-phenyl-N-(7-benzylaminomethylchroman-4-yl)-propionamide; 
     3-(Naphthalen-2-ylsulfonylamino)-3-phenyl-N-(7-phenylaminomethylchroman-4-yl)-propionamide; 
     3-(Naphthalen-2-ylsulfonylamino)-3-phenyl-N-(7-cyclohexylmethylaminomethylchroman-4-yl)-propionamide; 
     3-(Naphthalen-2-ylsulfonylamino)-3-phenyl-N-(7-cyclohexylaminomethylchroman-4-yl)-propionamide; 
     3-(Naphthalen-2-ylsulfonylamino)-3-phenyl-N-(2,2-dimethyl-7-(methylaminomethyl)chroman-4-yl)-propionamide; 
     3-(Naphthalen-2-ylsulfonylamino)-3-phenyl-N-(7-(piperidin-2-yl)chroman-4-yl)-propionamide; 
     3-(Naphthalen-2-ylsulfonylamino)-3-phenyl-N-(2,2-dimethyl-7-(1-methylpiperidin-2-yl)chroman-4-yl)-propionamide; 
     3-(Naphthalen-2-ylsulfonylamino)-3-phenyl-N-(3-isopropyl-7-(1-methylpiperidin-2-yl)chroman-4-yl)-propionamide; 
     3-(Naphthalen-2-ylsulfonylamino)-3-phenyl-N-(8-(2-methylethylaminoethyl)chroman-4-yl)-propionamide; 
     3-(Naphthalen-2-ylsulfonylamino)-3-phenyl-N-(8-diethylaminomethylchroman-4-yl)-propionamide; 
     3-(Naphthalen-2-ylsulfonylamino)-3-phenyl-N-(8-(4-methylpiperazin-1-ylmethyl)chroman-4-yl)-propionamide; 
     3-(Naphthalen-2-ylsulfonylamino)-3-phenyl-N-(8-piperazin-1-ylmethylchroman-4-yl)-propionamide; 
     3-(Naphthalen-2-ylsulfonylamino)-3-phenyl-N-(8-dimethylaminomethylchroman-4-yl)-propionamide; 
     3-(Naphthalen-2-ylsulfonylamino)-3-phenyl-N-(8-piperidin-1-ylmethylchroman-4-yl)-propionamide; 
     3-(Naphthalen-2-ylsulfonylamino)-3-phenyl-N-(6-(2-piperazin-1-ylethyl)chroman-4-yl)-propionamide; 
     3-(Naphthalen-2-ylsulfonylamino)-3-phenyl-N-(6-(2-methylethylaminoethyl)chroman-4-yl)-propionamide; 
     3-(Naphthalen-2-ylsulfonylamino)-3-phenyl-N-(6-diethylaminomethylchroman-4-yl)-propionamide; 
     3-(Naphthalen-2-ylsulfonylamino)-3-phenyl-N-(6-(4-methylpiperazin-1-ylmethyl)chroman-4-yl)-propionamide; 
     3-(Naphthalen-2-ylsulfonylamino)-3-phenyl-N-(6-piperazin-1-ylmethylchroman-4-yl)-propionamide; 
     3-(Naphthalen-2-ylsulfonylamino)-3-phenyl-N-(6-dimethylaminomethylchroman-4-yl)-propionamide; 
     3-(Naphthalen-2-ylsulfonylamino)-3-phenyl-N-(6-piperidin-1-ylmethylchroman-4-yl)-propionamide; 
     N-{7-[(Isobutylmethylamino)methyl]chroman-4-yl}-3-(3-pyridylsulfonylamino)-3-phenylpropionamide; 
     N-{7-[(Isobutylmethylamino)methyl]chroman-4-yl}-3-(5-chloro-3-methylbenzofur-2-ylsulfonylamino)-3-phenylpropionamide; 
     N-{7-[(Isobutylmethylamino)methyl]chroman-4-yl}-3-(5-methylbenzothien-2-ylsulfonylamino)-3-phenylpropionamide; 
     N-{7-[(Isobutylmethylamino)methyl]chroman-4-yl}-3-(5-fluoro-3-methylbenzothien-2-ylsulfonylamino)-3-phenylpropionamide; 
     N-{7-[(Isobutylmethylamino)methyl]chroman-4-yl}-3-(3,5-dimethylbenzothien-2-ylsulfonylamino)-3-phenylpropionamide; 
     N-{7-[(Isobutylmethylamino)methyl]chroman-4-yl}-3-(4-methylcyclohexylsulfonylamino)-3-phenylpropionamide; 
     N-{7-[(Isobutylmethylamino)methyl]chroman-4-yl}-3-(3-chloro-4-fluorophenylsulfonylamino)-3-phenylpropionamide; 
     N-{7-[(Isobutylmethylamino)methyl]chroman-4-yl}-3-(3,4-difluorophenylsulfonylamino)-3-phenylpropionamide; 
     N-{7-[(Isobutylmethylamino)methyl]chroman-4-yl}-3-(2,5-dichlorophenylsulfonylamino)-3-phenylpropionamide; 
     N-{7-[(Isobutylmethylamino)methyl]chroman-4-yl}-3-(4-chloro-2,5-dimethylphenylsulfonylamino)-3-phenylpropionamide; 
     N-{7-[(Isobutylmethylamino)methyl]chroman-4-yl}-3-(2,4,6-trimethylphenylsulfonylamino)-3-phenylpropionamide; 
     N-{7-[(Isobutylmethylamino)methyl]chroman-4-yl}-3-(2,4-dichloro-6-methylphenylsulfonylamino)-3-phenylpropionamide; 
     N-{7-[(Isobutylmethylamino)methyl]chroman-4-yl}-3-(4-chloro-benzo[1,2,5]oxadiazol-7-ylsulfonylamino)-3-phenylpropionamide; 
     N-{7-[(Isobutylmethylamino)methyl]chroman-4-yl}-3-(2-chlorothien-5-ylsulfonylamino)-3-phenylpropionamide; 
     N-{7-[(Isobutylmethylamino)methyl]chroman-4-yl}-3-(5-(isoxazol-3-yl)thien-2-ylsulfonylamino)-3-phenylpropionamide; 
     N-{7-[(Isobutylmethylamino)methyl]chroman-4-yl}-3-(3,5-di(trifluoromethyl)phenylsulfonylamino)-3-phenylpropionamide; 
     N-{7-[(Isobutylmethylamino)methyl]chroman-4-yl}-3-(4-butoxyphenylsulfonylamino)-3-phenylpropionamide; 
     N-{7-[(Isobutylmethylamino)methyl]chroman-4-yl}-3-(5-chloro-2-naphthylsulfonylamino)-3-phenylpropionamide; 
     N-{7-[(Isobutylmethylamino)methyl]chroman-4-yl}-3-(2,5-dichlorothien-3-ylsulfonylamino)-3-phenylpropionamide; 
     N-{7-[(Isobutylmethylamino)methyl]chroman-4-yl}-3-(2,3-dichlorothien-5-ylsulfonylamino)-3-phenylpropionamide; 
     N-{7-[(Isobutylmethylamino)methyl]chroman-4-yl}-3-(5-chloro-1,3-dimethyl-1H-pyrazol-4-ylsulfonylamino)-3-phenylpropionamide; 
     N-{7-[(Isobutylmethylamino)methyl]chroman-4-yl}-3-(5-chloro-benzo[1,2,5]thiadiazol-4-ylsulfonylamino)-3-phenylpropionamide; 
     N-{7-[(Isobutylmethylamino)methyl]chroman-4-yl}-3-(3-chlorobenzothien-2-ylsulfonylamino)-3-phenylpropionamide; 
     N-{7-[(Isobutylmethylamino)methyl]chroman-4-yl}-3-(3-methylbenzofur-2-ylsulfonylamino)-3-phenylpropionamide; 
     N-{7-[(Isobutylmethylamino)methyl]chroman-4-yl}-3-(6-bromonaphthylsulfonylamino)-3-phenylpropionamide; 
     N-{7-[(Isobutylmethylamino)methyl]chroman-4-yl}-3-(2-chloro-4-trifluoromethylphenylsulfonylamino)-3-phenylpropionamide; 
     N-{7-[(Isobutylmethylamino)methyl]chroman-4-yl}-3-(6-ethoxy-2-naphthylsulfonylamino)-3-phenylpropionamide; 
     N-{7-[(Isobutylmethylamino)methyl]chroman-4-yl}-3-(3-methyl-5-trifluoromethoxybenzothien-2-ylsulfonylamino)-3-phenylpropionamide; 
     N-{7-[(Isobutylmethylamino)methyl]chroman-4-yl}-3-(5-chloro-benzo[1,2,5]oxadiazol-4-ylsulfonylamino)-3-phenylpropionamide; 
     N-{7-[(Isobutylmethylamino)methyl]chroman-4-yl}-3-(3-methyl-5-methoxybenzofur-2-ylsulfonylamino)-3-phenylpropionamide; 
     N-{7-[(Isobutylmethylamino)methyl]chroman-4-yl}-3-(3-methyl-5-trifluoromethoxybenzofur-2-ylsulfonylamino)-3-phenylpropionamide; 
     N-{7-[(Isobutylmethylamino)methyl]chroman-4-yl}-3-(6-fluoroethoxy-2-naphthylsulfonylamino)-3-phenylpropionamide; 
     N-{7-[(Isobutylmethylamino)methyl]chroman-4-yl}-3-(7-methoxy-2-naphthylsulfonylamino)-3-phenylpropionamide; 
     N-{7-[(Isobutylmethylamino)methyl]chroman-4-yl}-3-(2,4-dichloro-5-methylphenylsulfonylamino)-3-phenylpropionamide; 
     N-{7-[(Isobutylmethylamino)methyl]chroman-4-yl}-3-(3-methylbenzothien-2-ylsulfonylamino)-3-phenylpropionamide; 
     N-{7-[(Isobutylmethylamino)methyl]chroman-4-yl}-3-(5-chloro-3-methylbenzothien-2-ylsulfonylamino)-3-phenylpropionamide; 
     N-{7-[(Isobutylmethylamino)methyl]chroman-4-yl}-3-(6-methoxy-3-methylbenzothien-2-ylsulfonylamino)-3-phenylpropionamide; 
     N-{7-[(Isobutylmethylamino)methyl]chroman-4-yl}-3-(5-methoxy-3-methylbenzothien-2-ylsulfonylamino)-3-phenylpropionamide; 
     N-{7-[(Isobutylmethylamino)methyl]chroman-4-yl}-3-(3-chloro-4-methylphenylsulfonylamino)-3-phenylpropionamide; 
     N-{7-[(Isobutylmethylamino)methyl]chroman-4-yl}-3-(4-t-butylphenylsulfonylamino)-3-phenylpropionamide; 
     N-{7-[(Isobutylmethylamino)methyl]chroman-4-yl}-3-(6-methoxy-2-naphthylsulfonylamino)-3-phenylpropionamide; 
     N-{7-[(Isobutylmethylamino)methyl]chroman-4-yl}-3-(2,3,4,5,6-pentamethylphenylsulfonylamino)-3-phenylpropionamide; 
     N-{7-[(Isobutylmethylamino)methyl]chroman-4-yl}-3-(benzothiazol-2-ylsulfonylamino)-3-phenylpropionamide; 
     N-{7-[(Isobutylmethylamino)methyl]chroman-4-yl}-3-(5-chloro-3-methylphenylsulfonylamino)-3-phenylpropionamide; 
     N-{7-[(Isobutylmethylamino)methyl]chroman-4-yl}-3-(5-(dimethylamino)naphth-1-ylsulfonylamino)-3-phenylpropionamide; 
     N-{7-[(Isobutylmethylamino)methyl]chroman-4-yl}-3-(benzo[1,2,5]oxadiazol-5-ylsulfonylamino)-3-phenylpropionamide; 
     N-{7-[(Isobutylmethylamino)methyl]chroman-4-yl}-3-(phenylethenylsulfonylamino)-3-phenylpropionamide; 
     N-{7-[(Isobutylmethylamino)methyl]chroman-4-yl}-3-(1-naphthylsulfonylamino)-3-phenylpropionamide; 
     N-{7-[(Isobutylmethylamino)methyl]chroman-4-yl}-3-(3,4-dichlorophenylsulfonylamino)-3-phenylpropionamide; 
     N-{7-[(Isobutylmethylamino)methyl]chroman-4-yl}-3-(2,4,5-trichlorophenylsulfonylamino)-3-phenylpropionamide; 
     N-{7-[(Isobutylmethylamino)methyl]chroman-4-yl}-3-(2,3,4-trichlorophenylsulfonylamino)-3-phenylpropionamide; 
     N-{7-[(Isobutylmethylamino)methyl]chroman-4-yl}-3-(2,4,6-trichlorophenylsulfonylamino)-3-phenylpropionamide; 
     N-{7-[(Isobutylmethylamino)methyl]chroman-4-yl}-3-(3-trifluoromethylphenylsulfonylamino)-3-phenylpropionamide; 
     N-{7-[(Isobutylmethylamino)methyl]chroman-4-yl}-3-(3-methylphenylsulfonylamino)-3-phenylpropionamide; 
     N-{7-[(Isobutylmethylamino)methyl]chroman-4-yl}-3-(4-biphenylsulfonylamino)-3-phenylpropionamide; 
     N-{7-[(Isobutylmethylamino)methyl]chroman-4-yl}-3-(3-biphenylsulfonylamino)-3-phenylpropionamide; 
     N-{7-[(Isobutylmethylamino)methyl]chroman-4-yl}-3-(2-chlorophenylsulfonylamino)-3-phenylpropionamide; 
     N-{7-[(Isobutylmethylamino)methyl]chroman-4-yl}-3-(3-fluorophenylsulfonylamino)-3-phenylpropionamide; 
     N-{7-[(Isobutylmethylamino)methyl]chroman-4-yl}-3-(3-methoxyphenylsulfonylamino)-3-phenylpropionamide; 
     N-{7-[(Isobutylmethylamino)methyl]chroman-4-yl}-3-(3,5-dichlorophenylsulfonylamino)-3-phenylpropionamide; 
     N-{7-[(Isobutylmethylamino)methyl]chroman-4-yl}-3-(4-methoxyphenylsulfonylamino)-3-phenylpropionamide; 
     N-{7-[(Isobutylmethylamino)methyl]chroman-4-yl}-3-(4-chlorophenylsulfonylamino)-3-phenylpropionamide; 
     N-{7-[(Isobutylmethylamino)methyl]chroman-4-yl}-3-(3-chlorophenylsulfonylamino)-3-phenylpropionamide; 
     N-{7-[(Isobutylmethylamino)methyl]chroman-4-yl}-3-(2-chlorophenylsulfonylamino)-3-phenylpropionamide; 
     N-{7-[(Isobutylmethylamino)methyl]chroman-4-yl}-3-(phenylsulfonylamino)-3-phenylpropionamide; 
     N-{7-[(Isobutylmethylamino)methyl]chroman-4-yl}-3-(2-quinolylsulfonylamino)-3-phenylpropionamide; 
     N-{7-[(Isobutylmethylamino)methyl]chroman-4-yl}-3-(2,4-dichloro-3-methylphenylsulfonylamino)-3-phenylpropionamide; 
     N-{7-[(Isobutylmethylamino)methyl]chroman-4-yl}-3-(5,6,7,8-tetrahydronaphth-2-ylsulfonylamino)-3-phenylpropionamide; 
     3-(Naphthalen-2-ylsulfonylamino)-3-(3-methylbenzofur-5-yl)-N-(7-piperidin-1-ylmethyl-chroman-4-yl)-propionamide; 
     3-(Naphthalen-2-ylsulfonylamino)-3-(2,3-dihydrofur-4-yl)-N-(7-piperidin-1-ylmethyl-chroman-4-yl)-propionamide; 
     3-(Naphthalen-2-ylsulfonylamino)-3-(benzo[1,2,5]oxadiazol-5-yl)-N-(7-piperidin-1-ylmethyl-chroman-4-yl)-propionamide; 
     3-(Naphthalen-2-ylsulfonylamino)-3-(2,3-dihydrofur-6-yl)-N-(7-piperidin-1-ylmethyl-chroman-4-yl)-propionamide; 
     3-(Naphthalen-2-ylsulfonylamino)-3-(4-benzofuryl)-N-(7-piperidin-1-ylmethyl-chroman-4-yl)-propionamide; 
     3-(Naphthalen-2-ylsulfonylamino)-3-(5-benzothienyl)-N-(7-piperidin-1-ylmethyl-chroman-4-yl)-propionamide; 
     3-(Naphthalen-2-ylsulfonylamino)-3-(4-trifluoromethylphenyl)-N-(7-piperidin-1-ylmethyl-chroman-4-yl)-propionamide; 
     3-(Naphthalen-2-ylsulfonylamino)-3-(6-benzofuryl)-N-(7-piperidin-1-ylmethyl-chroman-4-yl)-propionamide; 
     3-(Naphthalen-2-ylsulfonylamino)-3-(4-isopropylphenyl)-N-(7-piperidin-1-ylmethyl-chroman-4-yl)-propionamide; 
     3-(Naphthalen-2-ylsulfonylamino)-3-(5-benzofuryl)-N-(7-piperidin-1-ylmethyl-chroman-4-yl)-propionamide; 
     3-(Naphthalen-2-ylsulfonylamino)-3-(2-benzofuryl)-N-(7-piperidin-1-ylmethyl-chroman-4-yl)-propionamide; 
     3-(Naphthalen-2-ylsulfonylamino)-3-(4-bromophenyl)-N-(7-piperidin-1-ylmethyl-chroman-4-yl)-propionamide; 
     3-(Naphthalen-2-ylsulfonylamino)-3-(thiazol-2-yl)-N-(7-piperidin-1-ylmethyl-chroman-4-yl)-propionamide; 
     3-(Naphthalen-2-ylsulfonylamino)-3-(benzo[1,2,5]thiadiazol-5-yl)-N-(7-piperidin-1-ylmethyl-chroman-4-yl)-propionamide; 
     3-(Naphthalen-2-ylsulfonylamino)-3-(3,4-difluorophenyl)-N-(7-piperidin-1-ylmethyl-chroman-4-yl)-propionamide; 
     3-(Naphthalen-2-ylsulfonylamino)-3-(3-isopropylphenyl)-N-(7-piperidin-1-ylmethyl-chroman-4-yl)-propionamide; 
     3-(Naphthalen-2-ylsulfonylamino)-3-(3-thienyl)-N-(7-piperidin-1-ylmethyl-chroman-4-yl)-propionamide; 
     3-(Naphthalen-2-ylsulfonylamino)-3-(3-benzyloxyphenyl)-N-(7-piperidin-1-ylmethyl-chroman-4-yl)-propionamide; 
     3-(Naphthalen-2-ylsulfonylamino)-3-(3-furyl)-N-(7-piperidin-1-ylmethyl-chroman-4-yl)-propionamide; 
     3-(Naphthalen-2-ylsulfonylamino)-3-(3-phenyloxyphenyl)-N-(7-piperidin-1-ylmethyl-chroman-4-yl)-propionamide; 
     3-(Naphthalen-2-ylsulfonylamino)-3-(3,4-dimethoxyphenyl)-N-(7-piperidin-1-ylmethyl-chroman-4-yl)-propionamide; 
     3-(Naphthalen-2-ylsulfonylamino)-3-(3-pyridyl)-N-(7-piperidin-1-ylmethyl-chroman-4-yl)-propionamide; 
     3-(Naphthalen-2-ylsulfonylamino)-3-(4-chlorophenyl)-N-(7-piperidin-1-ylmethyl-chroman-4-yl)-propionamide; 
     3-(Naphthalen-2-ylsulfonylamino)-3-(3,4-dichlorophenyl)-N-(7-piperidin-1-ylmethyl-chroman-4-yl)-propionamide; 
     3-(Naphthalen-2-ylsulfonylamino)-3-(4-methylphenyl)-N-(7-piperidin-1-ylmethyl-chroman-4-yl)-propionamide; 
     3-(Naphthalen-2-ylsulfonylamino)-3-(3-methylphenyl)-N-(7-piperidin-1-ylmethyl-chroman-4-yl)-propionamide; 
     3-(Naphthalen-2-ylsulfonylamino)-3-(3-trifluoromethylphenyl)-N-(7-piperidin-1-ylmethyl-chroman-4-yl)-propionamide; 
     3-(Naphthalen-2-ylsulfonylamino)-3-(4-hydroxyphenyl)-N-(7-piperidin-1-ylmethyl-chroman-4-yl)-propionamide; 
     3-(Naphthalen-2-ylsulfonylamino)-3-(3-hydroxyphenyl)-N-(7-piperidin-1-ylmethyl-chroman-4-yl)-propionamide; 
     3-(Naphthalen-2-ylsulfonylamino)-3-(4-methoxyphenyl)-N-(7-piperidin-1-ylmethyl-chroman-4-yl)-propionamide; 
     3-(Naphthalen-2-ylsulfonylamino)-3-(3-methoxyphenyl)-N-(7-piperidin-1-ylmethyl-chroman-4-yl)-propionamide; 
     3-(Naphthalen-2-ylsulfonylamino)-3-(3-fluorophenyl)-N-(7-piperidin-1-ylmethyl-chroman-4-yl)-propionamide; 
     3-(Naphthalen-2-ylsulfonylamino)-3-(3-chlorophenyl)-N-(7-piperidin-1-ylmethyl-chroman-4-yl)-propionamide; 
     3-(Naphthalen-2-ylsulfonylamino)-3-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-N-(7-piperidin-1-ylmethyl-chroman-4-yl)-propionamide; 
     3-(Naphthalen-2-ylsulfonylamino)-3-benzodioxolyl-5-yl-N-(7-piperidin-1-ylmethyl-chroman-4-yl)-propionamide; 
     3-(Naphthalen-2-ylsulfonylamino)-3-(3,4-dimethylphenyl)-N-(7-piperidin-1-ylmethyl-chroman-4-yl)-propionamide; and 
     3-(Naphthalen-2-ylsulfonylamino)-3-cyclohexyl-N-(7-piperidin-1-ylmethyl-chroman-4-yl)-propionamide; 
     or a pharmaceutically acceptable salt thereof.