Neuroprotective dietary supplement

Abstract

The invention relates to a novel dietary supplement mixture having improved neuroprotective activity and preventing, ameliorating or counteracting neurodegeneration and preventing, counteracting and/or improving cognitive function decline. It also provides a dietary supplement, which is to be administered in an oral dosage form.

1 ) Dietary supplement mixture having neuroprotective activity which comprises a peptide formulation, comprising at least one of the two peptides defined by sequence 1: NMVPFPR or sequence 2: ASAFQGIGSTHWVYDGVGNS. 
     
     
         2 ) Dietary supplement mixture according to  claim 1  further comprising additional amino acids. 
     
     
         3 ) Dietary supplement mixture according to  claim 1  comprising further peptides with a molecular weight less than 10 kDa. 
     
     
         4 ) Dietary supplement mixture according to  claim 1  comprising trace elements and/or mineral substances and/or vitamins and/or caffeine and/or taurine and/or fatty acids and/or phospholipids, and/or phosphatidylserines and/or plant extracts. 
     
     
         5 ) Dietary supplement mixture according to  claim 1  further comprising acceptable additives and/or excipients and/or fillers and/or colouring substances and/or flavouring substances. 
     
     
         6 ) Oral dosage form comprising a dietary supplement mixture according to one of  claims 1 - 5  and acceptable additives and/or excipients and/or fillers and/or colouring substances and/or flavouring substances and/or solvents. 
     
     
         7 ) Oral dosage form comprising a dietary supplement mixture according to  claim 1 , comprising 2-20 wt % peptides. 
     
     
         8 ) Oral dosage form according to  claim 7  further comprising 10-30 wt % amino acids. 
     
     
         9 ) Use of the dietary supplement mixture according to one of the  claims 1 - 8 , for preventing, ameliorating or improving age-associated memory impairment and/or age-associated cognitive decline and/or benign senescent forgetfulness. 
     
     
         10 ) Use of the dietary supplement mixture according to one of the  claims 1 - 5 , to protect neurons against metabolic deficits and stress associated with aging processes. 
     
     
         11 ) Use of the dietary supplement mixture according to one of the  claims 1 - 5 , to prevent, counteract and/or ameliorate the consequences of age-related neuronal lesions due to hypoxia or ischaemia, the consequences of age-related neuronal lesions due to intracellular calcium overload, the consequences of age-related neuronal lesions induced by L-glutamate and excitotoxic events and the consequences of age-related neuronal lesions due to oxidative stress. 
     
     
         12 ) Use of the dietary supplement mixture according to one of the  claims 1 - 5 , to prevent, counteract and/or ameliorate the consequences of age-associated neurodegeneration, to prevent neuronal cell death due to cell stress, neurodegenerative events and intoxication, to maintain and preserve normal neuronal cytoarchitecture during aging processes, to support and/or improve synaptic function and synaptic density, to prevent, counteract, and or ameliorate the consequences of the age-related decline of synaptic plasticity and of synaptic density. 
     
     
         13 ) Use of the dietary supplement mixture according to one of the  claims 1 - 5 , to activate cerebral mechanisms related to attention and memory performance. 
     
     
         14 ) Use of the dietary supplement mixture according to one of the  claims 1 - 5 , to prevent, counteract, and/or improve cognitive function decline, to prevent, counteract, and/or improve memory function decline, to prevent, counteract, and/or improve attention deficits, to prevent, counteract, and/or improve a decrease of vigilance associated with aging processes and to support, maintain and or improve long term memory and procedural memory as well as learning performance, attention and vigilance. 
     
     
         15 ) Use of the dietary supplement mixture according to one of the  claims 1 - 5 , to preserve/support healthy mental function during the aging processes.