Receptacles and Kits, Such as for Dry Powder Packaging

Abstract

A receptacle ( 100 ) includes a holder ( 5 ) forming a cavity ( 25 ) that holds a pharmaceutical ( 110 ), a lid ( 15 ), and adhesive ( 17 ) that forms a bond ( 20 ) between the holder ( 5 ) and the lid ( 15 ). As an example, the bond ( 20 ) has a shape that includes a protrusion ( 30 ) that facilitates removal of the lid ( 15 ) from the holder ( 5 ). A kit ( 60 ) includes a plurality of containers containing powder including amphotericin B and pharmaceutically acceptable excipient. The kit ( 60 ) also includes an aerosolization apparatus ( 1100 ) and instructions. As an example, the pharmaceutical composition is made from panicles including amphotericin B having a mass median diameter less than about 3 μm, such as from about 1.1 μm to about 1.9 μm.

1 . A receptacle, comprising:
 a holder forming a cavity that holds a pharmaceutical;   a lid; and   adhesive that forms a bond between the holder and the lid, wherein the bond has a shape, and wherein the shape comprises a protrusion that facilitates removal of the lid from the holder.   
     
     
         2 . The receptacle of  claim 1 , wherein the protrusion comprises an arc, a substantially straight line, or both. 
     
     
         3 . The receptacle of  claim 1 , wherein the holder includes a substantially flat surface, the lid includes substantially flat surface, and said adhesive forms a bond between said substantially flat surfaces of the holder and the lid. 
     
     
         4 . The receptacle of  claim 3 , wherein the substantially flat surface of the lid comprises an unbonded portion that facilitates removal of the lid from the holder. 
     
     
         5 . The receptacle of  claim 1 , wherein the lid comprises a raised portion. 
     
     
         6 - 7 . (canceled) 
     
     
         8 . The receptacle of  claim 1 , wherein the receptacle is made by bonding a holder comprising adhesive to a lid. 
     
     
         9 . The receptacle of  claim 1 , wherein the holder comprises a laminate comprising thermoplastic. 
     
     
         10 . (canceled) 
     
     
         11 . The receptacle of  claim 1 , wherein the lid comprises a metal foil, a paper, a laminate comprising thermoplastic, and combinations thereof. 
     
     
         12 . The receptacle of  claim 1 , wherein the receptacle contains a capsule containing the pharmaceutical. 
     
     
         13 . The receptacle of  claim 12 , wherein the pharmaceutical comprises amphotericin B. 
     
     
         14 - 15 . (canceled) 
     
     
         16 . The receptacle of  claim 12 , wherein the pharmaceutical comprises a hormone. 
     
     
         17 . The receptacle of  claim 16 , wherein the hormone comprises a parthyroid hormone, fragment thereof, derivative thereof, analogs thereof, and combinations thereof. 
     
     
         18 . (canceled) 
     
     
         19 . The receptacle of  claim 12 , wherein the pharmaceutical comprises an anti-infective. 
     
     
         20 . The receptacle of  claim 19 , wherein the anti-infective is an antibiotic. 
     
     
         21 . The receptacle of  claim 20 , wherein the antibiotic is amikacin, gentamicin, vancomycin, tobramycin, ciprofloxacin, and combinations thereof. 
     
     
         22 . The receptacle of  claim 20 , wherein the antibiotic is tobramycin. 
     
     
         23 . (canceled) 
     
     
         24 . An array, comprising a plurality of the receptacles of  claim 1 , wherein the plurality of receptacles are attached to each other. 
     
     
         25 . The array of  claim 24 , wherein the array comprises a one-dimensional array. 
     
     
         26 . The array of  claim 24 , wherein the array comprises a two-dimensional array. 
     
     
         27 . The array of  claim 24 , wherein adjacent receptacles are separated by perforations. 
     
     
         28 . The array of  claim 24 , wherein adjacent receptacles are separate by at least one score cut. 
     
     
         29 . The array of  claim 24 , further comprising a backing on which the receptacles are mounted, wherein the backing is separable from the receptacles. 
     
     
         30 - 43 . (canceled) 
     
     
         44 . A kit, comprising:
 a plurality of containers containing powder comprising amphotericin B and pharmaceutically acceptable excipient;   an aerosolization apparatus; and   instructions,   wherein the pharmaceutical composition is made from particles comprising amphotericin B having a mass median diameter less than about 3 μm.   
     
     
         45 . The kit of  claim 44 , wherein the plurality of containers comprise capsules. 
     
     
         46 - 53 . (canceled)