Hla-binding peptide, precursor thereof, and dna fragment and recombinant vector coding for said hla-binding peptide

Abstract

An HLA-binding peptide binding to an HLA-A type molecule is provided that includes one or more types of amino acid sequence selected from the group consisting of SEQ ID NOS: 1 to 52, and not less than 8 and not more than 11 amino acid residues. All of these amino acid sequences are amino acid sequences predicted to bind to a human HLA-A molecule using a prediction program employing an active learning experiment method shown in FIG. 1.

1 . An HLA-binding peptide binding to an HLA-A type molecule, said HLA-binding peptide comprising
 one or more types of amino acid sequence selected from the group consisting of SEQ ID NOS: 1 to 52, and   not less than 8 and not more than 11 amino acid residues.   
     
     
         2 . The HLA-binding peptide as set forth in  claim 1 , comprising one or more types of amino acid sequence selected from the group consisting of SEQ ID NOS: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10,11, 12,13, 14, 15, 16,17, 18, 21, 22, 23, 24, 25, 26, 27, 28, 30, 31, 34, 35, 36, 37, 38, 40, 41, 43, 45, 47, 48, 49, 50, 51, and 52. 
     
     
         3 . An HLA-binding peptide binding to an HLA-A type molecule, said HLA-binding peptide comprising
 an amino acid sequence formed by deletion, substitution, or addition of one or two amino acid residues of said amino acid sequence contained in the HLA-binding peptide as set forth in  claim 1 , and   not less than 8 and not more than 11 amino acid residues.   
     
     
         4 . The HLA-binding peptide as set forth in  claim 1 , wherein said HLA-binding peptide binds to a human HLA-A*2402 molecule. 
     
     
         5 . The HLA-binding peptide as set forth in  claim 1 , wherein said HLA-binding peptide binds to a human HLA-A*0201 molecule. 
     
     
         6 . The HLA-binding peptide as set forth in  claim 1 , wherein said HLA-binding peptide binds to a human HLA-A*0206 molecule. 
     
     
         7 . A DNA fragment comprising a DNA sequence coding for the HLA-binding peptide as set forth in  claim 1 . 
     
     
         8 . A recombinant vector comprising a DNA sequence coding for the HLA-binding peptide as set forth in  claim 1 . 
     
     
         9 . An HLA-binding peptide precursor changing within a mammalian body into the HLA-binding peptide as set forth in  claim 1 .