US2009023894A1PendingUtilityA1

Neutralizing Antibody Against HGF

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Assignee: NAT CANCER CTPriority: Nov 11, 2003Filed: Jun 25, 2008Published: Jan 22, 2009
Est. expiryNov 11, 2023(expired)· nominal 20-yr term from priority
Inventors:Junho ChungYoungmi Hur
A61P 33/06A61P 35/00C07K 2317/55C07K 2317/76A61P 25/28C07K 16/22C07K 2317/24C07K 2317/56C07K 14/4753C07K 14/47
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Claims

Abstract

The neutralizing antibody against HGF binding to the inventive neutralizable epitope of HGF is capable of neutralizing HGF as a single agent, and can be effectively used for preventing and treating intractable diseases and cancers that are caused by binding of HGF to its receptor Met.

Claims

exact text as granted — not AI-modified
1 . A polypeptide neutralizing hepatocyte growth factor (HGF) which has the amino acid sequence of SEQ ID NO: 32 wherein said polypeptide inhibits the binding of HGF to cMet. 
     
     
         2 - 10 . (canceled) 
     
     
         11 . A polypeptide neutralizing hepatocyte growth factor (HGF) which has the amino acid sequence of SEQ ID NO: 33 wherein said polypeptide inhibits the binding of HGF to cMet.

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