Phamaceutical/cosmetic compositions comprising hyaluronic acid and treatment of dermatological conditions therewith

Abstract

Pharmaceutical/cosmetic compositions containing a dermatologically effective amount of hyaluronic acid, at least one retinoid and/or salt and/or derivative thereof, at least one oligosaccharide and at least one inhibitor of hyaluronic acid degradation, formulated into a physiologically acceptable medium therefor, are useful for the treatment of wrinkles, fine lines, fibroblast depletions and scars.

1 . A pharmaceutical/cosmetic composition which comprises a dermatologically effective amount of hyaluronic acid, at least one retinoid and/or salt and/or derivative thereof, at least one oligosaccharide and at least one inhibitor of hyaluronic acid degradation, formulated into a physiologically acceptable medium therefor. 
   
   
       2 . The pharmaceutical/cosmetic composition as defined by  claim 1 , said at least one retinoid and/or salt and/or derivative thereof comprising retinol. 
   
   
       3 . The pharmaceutical/cosmetic composition as defined by  claim 1 , said at least one oligosaccharide comprising a hyaluronic acid oligomer. 
   
   
       4 . The pharmaceutical/cosmetic composition as defined by  claim 1 , said at least one inhibitor of hyaluronic acid degradation comprising glycyrrhizin or glycyrrhetinic acid, and/or derivative and/or analog thereof. 
   
   
       5 . The pharmaceutical/cosmetic composition as defined by  claim 1 , formulated for topical application. 
   
   
       6 . The pharmaceutical/cosmetic composition as defined by  claim 1 , formulated for parenteral administration. 
   
   
       7 . The parenteral formulation as defined by  claim 6 , comprising a solution or suspension for perfusion or for injection. 
   
   
       8 . The pharmaceutical/cosmetic composition as defined by  claim 1 , formulated as a combination product for simultaneous, separate or sequential administration in the treatment of dermatological conditions/afflictions. 
   
   
       9 . The combination product as defined by  claim 8 , comprising a fraction A which comprises hyaluronic acid in the form of an injectable solution, and a fraction B which comprises at least one inhibitor of hyaluronic acid degradation, at least one oligosaccharide, and at least one retinoid and/or salt and/or derivative thereof, formulated for topical application. 
   
   
       10 . A process for the production of a pharmaceutical/cosmetic composition as defined by  claim 1 , comprising mixing an effective amount of hyaluronic acid, at least one retinoid and/or salt and/or derivative thereof, at least one oligosaccharide and at least one inhibitor of hyaluronic acid degradation, and formulating same into a physiologically acceptable medium therefor. 
   
   
       11 . A process for the production of a combination product as defined by  claim 9 , comprising:
 a first step of preparing an injectable solution, which comprises mixing the hyaluronic acid with a physiologically acceptable medium, and   a second step of formulating a composition suitable for topical administration, comprising mixing at least one retinoid and/or salt and/or derivative thereof with at least one oligosaccharide and at least one inhibitor of hyaluronic acid degradation in a physiologically acceptable medium therefor.   
   
   
       12 . A regime or regimen for the treatment and/or prevention of a dermatological condition or affliction, comprising administering to an individual in need of such treatment, a dermatologically effective amount of hyaluronic acid, at least one retinoid and/or salt and/or derivative thereof, at least one oligosaccharide and at least one inhibitor of hyaluronic acid degradation. 
   
   
       13 . A regime or regimen for conducting repair surgery on an individual in need of such treatment, comprising, before or during such repair surgery, administering to said individual a thus effective amount of hyaluronic acid, at least one retinoid and/or salt and/or derivative thereof, at least one oligosaccharide and at least one inhibitor of hyaluronic acid degradation. 
   
   
       14 . A regime or regimen for the treatment of wrinkles, fine lines, fibroblast depletions or scars afflicting an individual's skin, comprising filling same with a thus effective amount of hyaluronic acid, at least one retinoid and/or salt and/or derivative thereof, at least one oligosaccharide and at least one inhibitor of hyaluronic acid degradation. 
   
   
       15 . A dermal implant comprising hyaluronic acid, at least one retinoid and/or salt and/or derivative thereof, at least one oligosaccharide and at least one inhibitor of hyaluronic acid degradation.