Ly6h gene

Abstract

The invention provides a brain-specific gene useful in treating Alzheimer's disease, for instance, which comprises a nucleotide sequence cording for the amino acid sequence shown in SEQ ID NO:1 and fragments thereof; an expression vector comprising the gene; a host cell comprising the expression vector; an expression product of the gene; an antibody against the product; a therapeutic and prophylactic composition for neurodegenerative disease; and the like.

1 - 19 . (canceled) 
     
     
         20 . An antibody which binds specifically to a protein comprising the amino acid sequence of SEQ ID NO: 1. 
     
     
         21 . The antibody according to  claim 20 , wherein the protein is an expression product of an expression vector comprising:
 a polynucleotide consisting of the nucleotide sequence of SEQ ID NO: 2 or   a polynucleotide consisting of the nucleotide sequence of SEQ ID NO: 3.   
     
     
         22 . The antibody according to  claim 21 , wherein the expression vector comprises the polynucleotide consisting of the nucleotide sequence of SEQ ID NO: 2. 
     
     
         23 . The antibody according to  claim 21 , wherein the expression vector comprises the polynucleotide consisting of the nucleotide sequence of SEQ ID NO: 3. 
     
     
         24 . A method for detecting a wild-type or mutant LY6H in a sample, comprising subjecting said sample to a technique selected from the group consisting of immunoprecipitation, immunostaining, western blotting, ELISA, radioimmunoassay (RIA), immuno-radiometric assay (IRMA) and immuno-enzymometric assay (IEMA), and wherein said technique is performed with the antibody of  claim 20  or  21 . 
     
     
         25 . The method of  claim 24 , wherein said sample is a biological sample obtained from a human body.