US2008312583A1PendingUtilityA1

Topical composition for treating pain

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Individually held — no corporate assignee on recordPriority: Jun 12, 2007Filed: Jun 16, 2008Published: Dec 18, 2008
Est. expiryJun 12, 2027(~0.9 yrs left)· nominal 20-yr term from priority
Inventors:Bryan T. OronskyNeil C. OronskyArnold L. Oronsky
A61P 25/04A61P 3/04A61P 29/02A61P 29/00A61P 25/00A61K 9/0009A61P 11/08A61K 31/01A61K 9/0014A61K 31/23A61K 31/19A61K 31/215A61P 17/00A61P 1/14A61P 21/00A61K 31/685A61K 31/045A61P 11/00A61K 31/56A61P 19/02
60
PatentIndex Score
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Claims

Abstract

Topical compositions having as the active ingredient a lipid, fatty acid ester, natural wax, sterol, or combinations thereof referred to herein as “lipophilic vehicle” or “LV” and methods of use, have been developed for the amelioration or prevention of pain or the sequelae of pain. The composition may be in the form of an ointment, cream, gel, lotion, spray, foam, paste, patch, suspension or dispersion. In the preferred embodiment, the formulation is a gel. The LV may contain a penetration enhancer, most preferably one with membrane disruptive properties. The formulation may be applied to or impregnated into a gauze, wrap, bandage, cotton-tipped stick, adhesive bandage strip, or other support wrap or medical bandage or wound cover. For example, the compositions may be are incorporated onto or into disposables such as hemorrhoid wipes, sponge, mouth guards, dental trays; needles or catheters; adult diapers; gloves, socks or wrist bands, for ease of application. The composition is applied topically to a site at or adjacent to a painful region. The composition is reapplied as necessary. Pain relief is typically obtained within minutes and lasts for periods of variable duration ranging from minutes to several hours and even, in some cases, days. The composition is variably effective to treat visceral, somatic and neuropathic pain both acute and chronic as well as muscle pain and stiffness and joint pain and stiffness.

Claims

exact text as granted — not AI-modified
1 . A sharp device for performing a procedure comprising a coating of a lipophilic vehicle, wherein the lipophilic vehicle itself is capable of reducing or alleviating pain from the procedure. 
   
   
       2 . The sharp device of  claim 1  comprising a needle. 
   
   
       3 . The sharp device of  claim 1  comprising a lancet. 
   
   
       4 . The sharp device of  claim 1  wherein the lipophilic vehicle comprises a lipid, a phospholipid, a glycolipid, a fatty acid ester, a natural wax, a sterol, a seed oil, or a combination thereof. 
   
   
       5 . The sharp device of  claim 4  wherein the lipophilic vehicle comprises a phospholipid. 
   
   
       6 . The sharp device of  claim 5  wherein the phospholipid comprises lecithin. 
   
   
       7 . The sharp device of  claim 4  wherein the lipophilic vehicle comprises a fatty acid ester. 
   
   
       8 . The sharp device of  claim 7  wherein the fatty acid ester comprises isopropyl myristate. 
   
   
       9 . The sharp device of  claim 4  wherein the lipophilic vehicle comprises a natural wax. 
   
   
       10 . The sharp device of  claim 9  wherein the natural wax comprises beeswax or lanolin. 
   
   
       11 . The sharp device of  claim 4  wherein the lipophilic vehicle comprises a seed oil. 
   
   
       12 . The sharp device of  claim 11  wherein the seed oil comprises macadamia nut oil, grape seed oil, cottonseed oil, or sesame oil. 
   
   
       13 . The sharp device of  claim 1  wherein the coating further comprises a penetration enhancer. 
   
   
       14 . The sharp device of  claim 13  wherein the penetration enhancer comprises a sulphoxide, an azone, a pyrrolidone, an alcohol, an alkanol, an ether, a glycol, a surfactant, a terpene, or a combination thereof. 
   
   
       15 . The sharp device of  claim 1  wherein the coating further comprises an antiseptic, a disinfectant, or a preservative. 
   
   
       16 . A method for performing a procedure comprising:
 a) topically applying a lipophilic composition to a body site, the lipophilic composition comprising a lipophilic vehicle; and   b) inserting a sharp device through the surface of the body site,   wherein the lipophilic vehicle itself is capable of preventing, reducing, or alleviating pain from the sharp device insertion.   
   
   
       17 . The method of  claim 16  wherein the sharp device comprises a needle. 
   
   
       18 . The method of  claim 16  wherein the sharp device comprises a lancet. 
   
   
       19 . The method of  claim 16  wherein the lipophilic vehicle comprises a lipid, a phospholipid, a glycolipid, a fatty acid ester, a natural wax, a sterol, a seed oil, or a combination thereof. 
   
   
       20 . The method of  claim 19  wherein the lipophilic vehicle comprises a phospholipid. 
   
   
       21 . The method of  claim 20  wherein the phospholipid comprises lecithin. 
   
   
       22 . The method of  claim 19  wherein the lipophilic vehicle comprises a fatty acid ester. 
   
   
       23 . The method of  claim 22  wherein the fatty acid ester comprises isopropyl myristate. 
   
   
       24 . The method of  claim 19  wherein the lipophilic vehicle comprises a natural wax. 
   
   
       25 . The method of  claim 24  wherein the natural wax comprises beeswax or lanolin. 
   
   
       26 . The method of  claim 19  wherein the lipophilic vehicle comprises a seed oil. 
   
   
       27 . The method of  claim 26  wherein the seed oil comprises macadamia nut oil, grape seed oil, cottonseed oil, or sesame oil. 
   
   
       28 . The method of  claim 16  wherein the lipophilic composition further comprises a penetration enhancer. 
   
   
       29 . The method of  claim 28  wherein the penetration enhancer comprises a sulphoxide, an azone, a pyrrolidone, an alcohol, an alkanol, an ether, a glycol, a surfactant, a terpene, or a combination thereof. 
   
   
       30 . The method of  claim 16  wherein the lipophilic composition further comprises an antiseptic, a disinfectant, or a preservative. 
   
   
       31 . The method of  claim 16  wherein the lipophilic composition is topically applied using a substrate. 
   
   
       32 . The method of  claim 31  wherein the substrate is a pad, gauze, a patch, a sponge, a tissue, or a wipe. 
   
   
       33 . The method of  claim 16  wherein the lipophilic composition is applied prior to insertion of the sharp device. 
   
   
       34 . The method of  claim 16  wherein the lipophilic composition is applied following insertion of the sharp device. 
   
   
       35 . The method of  claim 16  further comprising topically reapplying the lipophilic composition. 
   
   
       36 . The method of  claim 16  wherein the procedure is a needlestick. 
   
   
       37 . A kit for performing a procedure comprising:
 a) one or more sharp devices;   b) a lipophilic composition comprising a lipophilic vehicle, wherein the lipophilic vehicle itself is capable of preventing, reducing, or alleviating pain from the procedure; and   c) optionally, one or more substrates for applying the lipophilic composition.   
   
   
       38 . The kit of  claim 37  wherein the one or more sharp devices comprises a needle, a lancet, or a combination thereof. 
   
   
       39 . The kit of  claim 37  wherein the one or more substrates is a pad, gauze, a patch, a sponge, a tissue, a wipe. 
   
   
       40 . The kit of  claim 37  wherein the one or more sharp devices is the sharp device of  claim 1 .

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