Easily Dispersible Lipidic Phase

Abstract

The present invention relates to the use of a lipidic phase comprising an oil and a lipophilic additive (LPA), which is suitable to make an oil-in-water emulsion by application of low energy or a manual operation. The lipidic phase contains a Lipophilic Additive (LPA) which forms self-assembly structures inside the emulsion oil droplets. The aqueous phase contains a hydrophilic emulsifier and the lipidic and aqueous phases are mixed without using classical high shearing devices or homogenisers.

1 . A method for preparing an oil-in-water emulsion comprising using a lipidic phase comprising an oil and a lipophilic additive (LPA), wherein the LPA content in the lipidic phase comprises between 0.25-wt-% and 84 wt-%, and a mixing of the lipidic phase and an aqueous phase containing an emulsifier is performed by using a manual operation or a low energy device. 
   
   
       2 . The method according to  claim 1 , wherein the LPA content in the lipidic phase is between 2.5 wt-% and 80 wt. 
   
   
       3 . The method according to  claim 1 , wherein the LPA content in the lipidic phase is between 5 wt-% and 80 wt %. 
   
   
       4 . The method according to  claim 1 , wherein the LPA content in the lipidic phase is between 10 wt-% and 80 wt %. 
   
   
       5 . Assembly comprising a pre-mix of a lipidic and an aqueous phase in a container comprising means for preparing an oil-in-water emulsion comprising an oil and a lipophilic additive (LPA), wherein the LPA content in the lipidic phase comprises between 0.25-wt-% and 84 wt-%, and mixing the lipidic phase and the aqueous phase containing an emulsifier using a manual operation or a low energy device. 
   
   
       6 . Assembly comprising a lipidic phase separated from an aqueous phase containing an emulsifier in a container, having an exit comprising means for mixing both phases and preparing an oil-in-water emulsion comprising an oil and a lipophilic additive (LPA), wherein the LPA content in the lipidic phase comprises between 0.25-wt-% and 84 wt-%, and mixing of the lipidic phase and the aqueous phase containing an emulsifier is performed using a manual operation or a low energy device. 
   
   
       7 . Assembly comprising a lipidic and an aqueous phase comprising an oil and a lipophilic additive (LPA), wherein the LPA content in the lipidic phase comprises between 0.25-wt-% and 84 wt-%, and mixing of the lipidic phase and the aqueous phase containing an emulsifier is performed using a manual operation or a low energy device, both phases being in a flexible pouch. 
   
   
       8 . Method according to  claim 1 , wherein the manual operations or low energy devices are selected from the group consisting of manual squeezing, magnetic stirring, hand shaking, spoon or whisk stirring, vortex mixing, membrane emulsification, static mixer, kitchen mixer, nano-and microfluidics devices, pouch mixing, any mixer which creates a turbulent flow, and combinations thereof. 
   
   
       9 . Oil-in-water emulsion comprising a lipidic and aqueous phase comprising an oil and a lipophilic additive (LPA), wherein the LPA content in the lipidic phase comprises between 0.25-wt-% and 84 wt-%, wherein the oil droplets are of a diameter of 5 nm to hundreds of micrometers and the droplets exhibit a nano-sized self-assembled structurization with hydrophilic domains having a diameter size of 0.5 to 200 nm due to the presence of the lipophilic additive in the lipidic phase and mixing of the lipidic phase and the aqueous phase containing an emulsifier is performed using a manual operation or a low energy device. 
   
   
       10 . Oil-in-water emulsion comprising an oil and a lipophilic additive (LPA), wherein the LPA content in the lipidic phase comprises between 0.25-wt-% and 84 wt-%, and mixing of the lipidic phase and an aqueous phase containing an emulsifier is performed by using a manual operation or a low energy device comprising the dispersed oil droplets having a nano-sized self-assembled structured interior comprising
 (i) an oil selected from the group of consisting of mineral oils, hydrocarbons, vegetable oils, waxes, alcohols, fatty acids, mono-, di-, tri-acylglycerols, essential oils, flavouring oils, lipophilic vitamins, esters, nutraceuticals, terrapins, terpenes and mixtures thereof,   (ii) a lipophilic additive (LPA) or mixtures of lipophilic and hydrophilic additives, having a resulting HLB value (Hydrophilic-Lipophilic Balance) lower than about 10,   (iii) hydrophilic domains   and   an aqueous continuous phase.   
   
   
       11 . Method according to  claim 1 , wherein the oil droplets have an internal structure selected from the group consisting of L2 structure, a combination of L2 and oil structure in the temperature range of 0° C. to 100° C. 
   
   
       12 . Method according to  claim 1 , wherein the oil droplets have a L2 internal structure in the temperature range of 0° C. to 100° C. 
   
   
       13 . Method according to  claim 1 , wherein the oil droplets have an internal structure selected from the group consisting of L2 structure, reversed micellar cubic, or reversed bicontiunous L3 structure, and a combination thereof in the temperature range of 0° C. to 100° C. 
   
   
       14 . Method according to  claim 1 , wherein the oil droplets have a reversed micellar cubic internal structure in the temperature range of 0° C. to 100° C. 
   
   
       15 . Method according to  claim 1 , wherein the oil droplets have a reversed hexagonal internal structure in the temperature range of 0° C. to 100° C. 
   
   
       16 . Method according to  claim 1 , wherein the oil droplets comprise a material selected from the group consisting of flavours, flavour precursors, drugs, lutein, lutein esters, β-carotene, tocopherol, tocopherol acetate, tocotrienol, lycopene, Co-Q 10 , flax seed oil, lipoic acid, vitamin B 12 , vitamin D, α-and γ-polyunsaturated fatty acids or phytosterols, food supplements, food additives, plant extracts, medicaments, cosmoceuticals, peptides, proteins, carbohydrates, nutrients, aromas, and aroma precursors. 
   
   
       17 . Method according to  claim 1 , wherein the LPA is selected from the group consisting of long-chain alcohols, fatty acids, pegylated fatty acids, glycerol fatty acid esters, monoglycerides, diglycerides, derivatives of mono-diglycerides, pegylated vegetable oils, sorbitan esters, polyoxyethylene sorbitan esters, propylene glycol mono- or diesters, phospholipids, phosphatides, cerebrosides, gangliosides, cephalins, lipids, glycolipids, sulfatides, sugar esters, sugar ethers, sucrose esters, sterols, and polyglycerol esters. 
   
   
       18 . Method according to  claim 17 , wherein the LPA is selected from the group consisting of myristic acid, oleic acid, lauric acid, stearic acid, palmitic acid, PEG 1-4 stearate, PEG 2-4 oleate, PEG-4 dilaurate, PEG-4 dioleate, PEG-4 distearate, PEG-6 dioleate, PEG-6 distearate, PEG-8-dioleate, PEG-3-16 castor oil, PEG 5-10 hydrogenated castor oil, PEG 6-20 corn oil, PEG 6-20 almond oil, PEG-6 olive oil, PEG-6 peanut oil, PEG-6 palm kernel oil, PEG-6 hydrogenated palm kernel oil, PEG-4 capric/caprylic triglyceride, mono, di, tri, tetraesters of vegetable oil and sorbitol, pentaerythrityl di, tetra stearate, isostearate, oleate, caprylate or caprate, polyglyceryl-3 dioleate, stearate, or isostearate, polyglyceryl 4-10 pentaoleate, polyglyceryl 2-4 oleate, stearate, or isostearate, polyglyceryl 4-10 pentaoleate, polyglyceryl-3 dioleate, polyglyceryl-6 dioleate, polyglyceryl-10 trioleate, polyglyceryl-3 distearate propylene glycol mono- or diesters of C 6  to C 20  fatty acid, monoglycerides of C 6  to C 20  fatty acid, lactic acid derivatives of monoglycerides, lactic acid derivatives of diglycerides, diacetyl tartaric ester of monoglycerides, triglyceryl monostearate cholesterol, phytosterol, PEG 5-20 soya sterol, PEG-6 sorbitan tetra, hexasterarate, PEG-6 sorbitan tetraoleate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan mono trioleate, sorbitan mono and tristearate, sorbitan monoisostearate, sorbitan sesquioleate, sorbitan sesquistearate, PEG-2-5 oleyl ether, POE 2-4 lauryl ether, PEG-2 cetyl ether, PEG-2 stearyl ether, sucrose distearate, sucrose dipalmitate, ethyl oleate, isopropyl myristate, isopropyl palmitate, ethyl linoleate, isopropyl linoleate, poloxamers, phospholipids, lecithins, cephalins, oat lipids and lipophilic amphiphilic lipids from other plants and mixtures thereof. 
   
   
       19 . Method according to  claim 1 , wherein the emulsifier is selected from the group consisting of low molecular weight surfactants having a HLB>8, proteins from milk or soya, peptides, protein hydrolysates, block co-polymers, surface active hydrocolloids such as arabic gum, xanthan gum, surfactant-protein nanoparticles, surfactant stabilized nano-or micro silica particle and mixtures thereof. 
   
   
       20 . A lipidic phase in powder form, which is easily reconstituted into an aqueous phase at room or cold temperatures comprising using a lipidic phase comprising an oil and a lipophilic additive (LPA), wherein the LPA content in the lipidic phase comprises between 0.25-wt-% and 84 wt-%, and mixing of the lipidic phase and an aqueous phase containing an emulsifier is performed by using a manual operation or a low energy device. 
   
   
       21 . The lipidic phase according to  claim 20 , wherein it is a final product. 
   
   
       22 . The lipidic phase according to  claim 20 , wherein it is selected from the group consisting of a starting material, an intermediate product and an additive to a final product. 
   
   
       23 . Oil-in-water emulsion comprising dispersed oil droplets having a nano-sized self-assembled structured interior comprising
 (i) an oil selected from the group of consisting of mineral oils, hydrocarbons, vegetable oils, waxes, alcohols, fatty acids, mono-, di-, tri-acylglycerols, essential oils, flavouring oils, lipophilic vitamins, esters, nutraceuticals, terrapins, terpenes and mixtures thereof,   (ii) a lipophilic additive (LPA) or mixtures of lipophilic and hydrophilic additives, having a resulting HLB value (Hydrophilic-Lipophilic Balance) lower than about 10,   (iii) hydrophilic domains comprising of water or a non-aqueous polar liquid, comprising an aqueous continuous phase; and   the LPA contact of the lipidic phase prior to mixing is 0.25-wt-%-84 wt-% and mixing is through use of an operation selected from the group consisting of manual mixing and use of a low energy device.