Intraorally Rapidly Disintergrating Tablets and Their Production

Abstract

The object of the present invention is to provide, as a solid preparation for making it easy to take, thus improving patient's compliance etc., an intraorally rapidly disintegrating tablet which can be produced easily without any particular problem by a usual method of producing tablets with a usual tabletting machine, has practically unproblematic hardness, and disintegrate rapidly in the oral cavity. This tablet is produced by tabletting cores coated with a pharmaceutical disintegrating agent, wherein the core is a granule containing a water-soluble medicament or containing a medicament and a sugar.

1 .- 5 . (canceled) 
   
   
       6 . A method of producing an intraorally rapidly disintegrating tablet, comprising the following steps:
 a. producing a core containing an active ingredient and at least one sugar, or containing a water soluble active ingredient;   b. coating the core with a pharmaceutically acceptable powdered disintegrating agent to form a granule; and   c. tableting the granule.   
   
   
       7 . The method of  claim 6 , wherein the pharmaceutically acceptable disintegrating agent is a compound selected from the grout) consisting of crystalline cellulose, low-substituted hydroxypropyl cellulose, carboxymethyl cellulose, calcium carboxymethyl cellulose, crospovidone and starch represented by potato starch, wheat starch, corn starch, rice starch, hydroxypropyl starch, sodium carboxymethyl starch and partial-pregelantinized starch. 
   
   
       8 . The method of  claim 6 , wherein the sugar is selected from the group consisting of sugar alcohol represented by mannitol, xylitol, sorbitol, eryritol, maltitol and maltose; lactose, sucrose, glucose, and oligosaccharide. 
   
   
       9 . The method of  claim 6 , wherein the average particle diameter of the granules is in the range of 20 to 1000 μm. 
   
   
       10 . The method of  claim 6 , wherein the thickness of the tablet is in the range of 1 to 10 mm.