Wound-Healing Pharmaceutical Compositions in the Form of a Cream Based on Amino Acids and Sodium Hyaluronate

Abstract

This invention relates to wound-healing pharmaceutical or cosmetic (anti-skin aging) compositions in the form of a cream based on amino acids and sodium hyaluronate.

1 - 6 . (canceled) 
   
   
       7 . A pharmaceutical composition in form of a cream, the pharmaceutical composition containing as active ingredient a combination of:
 a) glycine and proline; and   b) sodium hyaluronate   
   
   
       8 . The pharmaceutical composition of  claim 7 , the composition further comprising as active ingredient:
 c) lysine and leucine.   
   
   
       9 . The pharmaceutical composition of  claim 7 , wherein proline is L-proline, and wherein glycine, L-proline and sodium hyaluronate are comprised within the following percentage ranges by weight:
 glycine 0.5 to 2%;   L-proline: 0.2 to 1.50%; and   sodium hyaluronate: 0.5 to 3%;   
   
   
       10 . The pharmaceutical composition of  claim 8 , wherein lysine is L-lysine, leucine is L-leucine, and wherein L-lysine and L-leucine are comprised within the following percentage ranges by weight:
 L-lysine hydrochloride: 0.05 to 1%; and   L-leucine: 0.05 to 0.3%.   
   
   
       11 . The pharmaceutical composition of  claim 7 , wherein proline is L-proline, and wherein glycine, L-proline and sodium hyaluronate have the following percentage ranges by weight:
 glycine 1%;   L-proline: 0.75%; and   sodium hyaluronate: 1.33%;   
   
   
       12 . The pharmaceutical composition of  claim 8 , wherein lysine is L-lysine, leucine is L-leucine and wherein L-lysine and L-leucine have the following percentage ranges by weight:
 L-lysine hydrochloride 0.1%; and   L-leucine: 0.15%.   
   
   
       13 . A method for treating a wound in a biological tissue, the method comprising
 administering to the biological tissue a medicament in form of a cream, the medicament comprising a combination of   a) glycine and proline; and   b) sodium hyaluronate.   
   
   
       14 . The method of  claim 13 , wherein the medicament further comprises lysine and leucine. 
   
   
       15 . The method of  claim 13 , wherein, the wound is a surgical wound, a vaginal lesion, a rectal lesion, a buccal wound or lesion, a wound from dental surgery, a chronic ulcerous wound, a serious burn, a bedsore or a wound associated with skin aging. 
   
   
       16 . A method to promote regeneration of epithelial cells of a vaginal or rectal tissue, the method comprising
 administering to the vaginal or rectal tissue a medicament in form of a cream for vaginal or rectal administration, the medicament comprising a combination of
 a) glycine and proline; and 
 b) sodium hyaluronate. 
   
   
   
       17 . The method of  claim 16 , wherein the medicament further comprises lysine and leucine. 
   
   
       18 . A method to promote regeneration of epithelial cells of a buccal tissue, the method comprising
 administering to the buccal tissue a medicament in form of a cream for buccal administration, the medicament comprising a combination of
 a) glycine and proline; and 
 b) sodium hyaluronate. 
   
   
   
       19 . The method of  claim 18 , wherein the medicament further comprises lysine and leucine.