US2008287357A1PendingUtilityA1

Conjugate Comprising P21 Protein for the Treatment of Cancer

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Assignee: TROJAN TECHNOLOGIES LTDPriority: Apr 14, 2005Filed: Apr 18, 2006Published: Nov 20, 2008
Est. expiryApr 14, 2025(expired)· nominal 20-yr term from priority
Inventors:Agamemnon EpenetosChristina Kousparou
A61P 35/00A61P 43/00A61P 31/00A61K 38/005A61K 38/1767A61K 45/06A61K 38/1709C07K 2319/10C07K 14/43581A61K 31/513A61K 31/555A61K 31/337A61K 47/64C07K 14/4738C12N 15/62C07K 14/435C07K 14/47A61K 33/243
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Claims

Abstract

The P21 protein is used as a medicament in the treatment of cancer. A conjugate comprises a first region comprising the P21 protein, or a homologue or functional fragment thereof; and a second region comprising a translocation factor.

Claims

exact text as granted — not AI-modified
1 - 13 . (canceled) 
     
     
         14 : A conjugate comprising:
 a) a first region comprising the P21 protein having the amino acid sequence as defined in SEQ ID No. 1, or a homologue thereof having at least 60% sequence identity thereto; and   b) a second region comprising a translocation factor.   
     
     
         15 : The conjugate according to  claim 14 , wherein the translocation factor comprises the homeodomain of antennapedia or a homologue or functional fragment thereof. 
     
     
         16 : The conjugate according to  claim 14 , wherein the translocation factor comprises a histone protein or a homologue or functional fragment thereof. 
     
     
         17 : The conjugate according to  claim 14 , wherein the translocation factor comprises a TAT protein or a homologue or functional fragment thereof. 
     
     
         18 : The conjugate according to  claim 14 , wherein the conjugate is a fusion protein. 
     
     
         19 : A nucleic acid encoding the conjugate according to  claim 14 . 
     
     
         20 : An expression vector comprising the nucleic acid of  claim 19 , operably linked to a promoter. 
     
     
         21 : A composition comprising:
 (i) a conjugate comprising
 a) a first region comprising the P21 protein having the amino acid sequence as defined in SEQ ID NO:1, or a homologue thereof having at least 60% sequence identity thereto or a functional fragment thereof; and 
 b) a second region comprising a translocation factor; and 
   (ii) a chemotherapeutic drug.   
     
     
         22 : A composition comprising the conjugate according to  claim 14  in combination with at least one drug. 
     
     
         23 : The composition according to  claim 22 , wherein the drug is chemotherapeutic. 
     
     
         24 : A method for the treatment of cancer, comprising administering the conjugate of  claim 14  to a subject in need thereof.

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