US2008282780A1PendingUtilityA1

Sire Flow Detector

39
Assignee: KRIZ DARIOPriority: Jul 8, 2004Filed: Jun 15, 2005Published: Nov 20, 2008
Est. expiryJul 8, 2024(expired)· nominal 20-yr term from priority
Inventors:Dario Kriz
G01N 27/40B82B 1/00B01L 2200/16B01L 2300/0877B01L 3/5027G01N 33/48B01L 2300/0645
39
PatentIndex Score
0
Cited by
0
References
0
Claims

Abstract

The present invention concerns a device and a method for the rapid detection of a low molecular substance in a liquid flow.

Claims

exact text as granted — not AI-modified
1 . A biosensor device, containing a semi-permeable membrane with nano-pores having an average cross-section in the range of 0.1 to 900 nm, where said membrane separates two flow-through chambers, where the first of the flow-through chambers contains a detector of the amperometric type and an inlet and an outlet for a liquid flow containing enzymatic reagents, and where the second flow-through chamber has an inlet and an outlet for a liquid flow containing chemical substances for qualitative and/or quantitative detection. 
   
   
       2 . A device according to  claim 1 , wherein said device is also equipped with a temperature sensor for temperature compensation of the measurements. 
   
   
       3 . A device according to  claim 2 , wherein said temperature sensor is of the type Pt 100 , Pt 1000 , DS 1820 , LM 35 , or KTY  81 - 120 . 
   
   
       4 . A device according to  claim 1 , wherein the device is equipped with a heat-generating or cooling element for controlling the temperature of the device at a constant temperature within the range of 5 to 80 degrees Celsius. 
   
   
       5 . A device according to  claim 1 , wherein said detector consists of a working electrode made of platinum, a reference electrode made of silver, and a counter electrode made of platinum. 
   
   
       6 . A device according to  claim 1 , wherein said working electrode has a potential that is +200 to +1000 mV above the reference electrode potential. 
   
   
       7 . A device according to  claim 1 , wherein both the above mentioned flow-through chambers each have a chamber volume within the range of 0.1 to 5000 μl. 
   
   
       8 . A device according to  claim 1 , wherein said semi-permeable membrane consists of cellulose acetate, Nafion, ceramic material, metallurgic material or polymeric material with a limitation of the permeability of high-molecular substances, exemplified but not limited to enzymes, proteins, cells, cell components, and polymers. 
   
   
       9 . A method where the device according to  claim 1  is used for qualitative and/or quantitative determination of low-molecular (Mw<5 kDa) substances in a liquid flow from a micro-dialysis probe, fermenter, cell suspension, chemical reactor, human being, tissue or animal. 
   
   
       10 . A method where the device according to  claim 1  is used for optimisation, control, or regulation of chemical or biological processes in fermenters, cell suspensions or chemical reactors. 
   
   
       11 . A device according to  claim 2 , wherein the device is equipped with a heat-generating or cooling element for controlling the temperature of the device at a constant temperature within the range of 5 to 80 degrees Celsius. 
   
   
       12 . A device according to  claim 3 , wherein the device is equipped with a heat-generating or cooling element for controlling the temperature of the device at a constant temperature within the range of 5 to 80 degrees Celsius. 
   
   
       13 . A device according to  claim 2 , wherein said detector consists of a working electrode made of platinum, a reference electrode made of silver, and a counter electrode made of platinum. 
   
   
       14 . A device according to  claim 3 , wherein said detector consists of a working electrode made of platinum, a reference electrode made of silver, and a counter electrode made of platinum. 
   
   
       15 . A device according to  claim 4 , wherein said detector consists of a working electrode made of platinum, a reference electrode made of silver, and a counter electrode made of platinum. 
   
   
       16 . A device according to  claim 2 , wherein said working electrode has a potential that is +200 to +1000 mV above the mentioned reference electrode potential. 
   
   
       17 . A device according to  claim 2 , wherein both the above mentioned flow-through chambers each have a chamber volume within the range of 0.1 to 5000 μl. 
   
   
       18 . A device according to  claim 1 , wherein said semi-permeable membrane consists of cellulose acetate, Nafion, ceramic material, metallurgic material or polymeric material with a limitation of the permeability of high-molecular substances, exemplified but not limited to enzymes, proteins, cells, cell components, and polymers. 
   
   
       19 . A method where the device according to  claim 2  is used for qualitative and/or quantitative determination of low-molecular (Mw<5 kDa) substances in a liquid flow from a micro-dialysis probe, fermenter, cell suspension, chemical reactor, human being, tissue or animal. 
   
   
       20 . A method where the device according to  claim 2  is used for optimisation, control, or regulation of chemical or biological processes in fermenters, cell suspensions or chemical reactors.

Join the waitlist — get patent alerts

Track US2008282780A1 — get alerts on status changes and closely related new filings.

We store only your email — no account needed. See our privacy policy.