US2008279825A1PendingUtilityA1

Cartilage material

63
Individually held — no corporate assignee on recordPriority: May 10, 2007Filed: May 10, 2007Published: Nov 13, 2008
Est. expiryMay 10, 2027(~0.8 yrs left)· nominal 20-yr term from priority
Inventors:Theodore I. Malinin
A61L 27/56A61K 35/32A61L 27/3654A61F 2/30965A61F 2310/00365A61L 2430/06A61F 2002/4495A61F 2/3094A61L 27/3683A61L 2430/40A61F 2002/30764A61P 19/00A61F 2/30756A61L 27/3695A61L 27/3612
63
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Claims

Abstract

Cartilage materials such as cartilage fluff and a cartilage composition comprising a particulate material are disclosed. These are suitable for stimulating chondrogenesis and/or producing cartilage regeneration. Also disclosed are processes for their preparation. Methods for regenerating articular cartilage are also disclosed, which involve, for example, placing the cartilage fluff or cartilage composition into a cartilage defect.

Claims

exact text as granted — not AI-modified
1 . A cartilage fluff comprising an animal cartilage material in the form of a fluff. 
     
     
         2 . The cartilage fluff of  claim 1 , which comprises strands of animal cartilage material, said strands having an average length of about 200 μm to about 3,000 μm. 
     
     
         3 . The cartilage fluff of  claim 1 , which comprises strands of animal cartilage material, said strands having an average width of about 40 μm to about 140 μm. 
     
     
         4 . The cartilage fluff of  claim 1 , which comprises strands of animal cartilage material, said strands having one or more branches of an average width up to about 50 μm. 
     
     
         5 . The cartilage fluff of  claim 4 , wherein the one or more branches are intertwined with one or more of said strands. 
     
     
         6 . The cartilage fluff of  claim 1 , wherein the strands have an average length from about 1,000 μm to about 3,000 μm. 
     
     
         7 . The cartilage fluff of  claim 1 , wherein the strands have at least one or more strands having branches of an average width from about 5 μm to about 50 μm. 
     
     
         8 . The cartilage fluff of  claim 1 , wherein the animal cartilage material comprises chemically untreated non-demineralized articular cartilage. 
     
     
         9 . The cartilage fluff of  claim 1 , wherein the animal cartilage material comprises one of hyaline cartilage, fibrocartilage, and mixtures thereof. 
     
     
         10 . The cartilage fluff of  claim 1 , wherein the animal cartilage material comprises one of allogeneic cartilage, xenogeneic cartilage, and mixtures thereof. 
     
     
         11 . The cartilage fluff of  claim 1 , wherein the animal cartilage comprises human cartilage. 
     
     
         12 . A method of regenerating cartilage in an animal in need thereof comprising administering an effective amount of the cartilage fluff of  claim 1  to a site of the animal where there is a need for regenerating articular cartilage. 
     
     
         13 . The method of  claim 12 , wherein the cartilage fluff is applied without the use of a vehicle. 
     
     
         14 . A method of preparing a cartilage fluff according to  claim 1 , comprising freeze-drying cartilage to obtain a freeze-dried cartilage, grinding the freeze-dried cartilage to obtain a ground material comprising cartilage fluff, and separating the cartilage fluff from the ground material. 
     
     
         15 . A method of preparing a cartilage fluff according to  claim 1 , comprising securing bone with cartilage in a milling and digitizing machine, and shaving the cartilage to obtain the cartilage fluff. 
     
     
         16 . The method of  claim 15 , wherein the shaving is carried out with a drill bit, core drill, or burr. 
     
     
         17 . A method of preparing a cartilage fluff according to  claim 1 , comprising freeze-drying articular cartilage and milling the freeze-dried cartilage to obtain the cartilage fluff. 
     
     
         18 . The method of  claim 17 , wherein said articular cartilage is attached to bone. 
     
     
         19 . The method of  claim 17 , wherein said articular cartilage is unattached to bone. 
     
     
         20 . A method of preparing a cartilage fluff according to  claim 1 , comprising processing fluff from frozen cartilage or from cryopreserved cartilage. 
     
     
         21 . A cartilage composition comprising non-demineralized particulate cartilage having an average particle size greater than 1,000 μm. 
     
     
         22 . The cartilage composition according to  claim 21 , wherein the non-demineralized particulate cartilage comprises chemically untreated non-demineralized particular articular cartilage. 
     
     
         23 . The cartilage composition according to  claim 21 , wherein the non-demineralized particulate cartilage comprises one of hyaline cartilage, fibrocartilage, and mixtures thereof. 
     
     
         24 . The cartilage composition according to  claim 21 , wherein the non-demineralized particulate cartilage comprises one of allogeneic cartilage, xenogeneic cartilage, and mixtures thereof. 
     
     
         25 . The cartilage composition according to  claim 21 , wherein the cartilage comprises human cartilage. 
     
     
         26 . A method of preparing a cartilage composition according to  claim 21 , comprising freeze-drying cartilage to obtain a freeze-dried cartilage, grinding the freeze-dried cartilage to obtain a ground material comprising a particulate cartilage composition, and separating the particulate cartilage composition from the ground material. 
     
     
         27 . A method of regenerating articular cartilage in an animal in need thereof comprising administering an effective amount of the cartilage composition of  claim 21  to a site of the animal where there is need for regenerating cartilage. 
     
     
         28 . The method of  claim 27 , wherein the cartilage composition comprises chemically untreated non-demineralized particular articular cartilage. 
     
     
         29 . The method of  claim 27 , wherein the cartilage composition comprises one of hyaline cartilage, fibrocartilage, and mixtures thereof. 
     
     
         30 . The method of  claim 27 , wherein the cartilage composition comprises one of allogeneic cartilage, xenogeneic cartilage, and mixtures thereof. 
     
     
         31 . The method of  claim 27 , wherein the cartilage composition comprises human cartilage.

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