Amino acid supplementation for a healthy microbiota ecosystem

Abstract

The present invention pertains to a nutritional composition for reconstituting an optimal healthy microbiota ecosystem in humans or animals. In particular, the present invention relates to an ingestible carrier containing specific amino acids designed to favor the growth of bacteria favorable to individuals health or for reducing the risk of developing deleterious events. The invention also pertains to the use of specific amino acids for reconstituting an optimal healthy microbiota ecosystem in humans or animals, in particular in infants, critically ill patients, in the case of chronic diseases or any stresses impacting the gut and in elderly people.

1 - 5 . (canceled) 
     
     
         6 . A method for the preparation of a nutritional composition or medicament intended for restoring or promoting a healthy and optimal microbiota ecosystem in humans or pets comprising the use of at least one amino acid or a mixture of amino acids in an amount efficient to favor the growth of bacterial microbiota. 
     
     
         7 . A method for the preparation of a composition or medicament intended for restoring or maintaining the integrity of gut barrier in frail population, such as infant, elderly or pet that present fragile ecosystem comprising the use of at least one amino acid or a mixture of amino acids in an amount efficient to favor the growth of bacterial microbiota. 
     
     
         8 . A method for stimulating the immune defenses and reduce allergy in individuals, such as infant, elderly or pet that present fragile ecosystem comprising administering a composition comprising of at least one amino acid or a mixture of amino acids in an amount efficient to favor the growth of bacterial microbiota for the preparation of a composition or medicament to one having a fragile ecosystem. 
     
     
         9 . The method according to  claim 6 , wherein the amino acid is selected from the group consisting of hydroxyl amino acids, sulfur-containing amino acids and heterocyclic amino acids. 
     
     
         10 . The method according to  claim 6 , wherein the amino acid is in the form selected from the group consisting of free amino acids, amino acids hydrolysates of different source of animal or plant proteins, protein source enriched in form of synthetic peptides, with free amino acids, entire proteins from natural source or synthetically peptides, or combinations thereof. 
     
     
         11 . The method according to  claim 6 , which comprises an amino acid selected from the group consisting of Serine in an amount of about 0.07 to 0.35 g/kg body weight/day; Proline in an amount of about 0.07 to 0.3 g/kg body weight/day, Threonine in an amount of about 0.04 to 0.20 g/kg body weight/day and Cysteine in an amount of about 0.03 to 0.15 g/kg body weight/day. 
     
     
         12 . A method for restoring or promoting a healthy and optimal microbiota ecosystem in humans or pets, which comprises administering to the individual a nutritional composition comprising at least one amino acid in an amount efficient to favor the growth and balance of bacterial microbiota and to reduce pathogens proliferation and risks of translocations. 
     
     
         13 . A method for restoring or maintaining the integrity of gut barrier in frail population, such as infant, elderly or pet that present fragile ecosystem, which comprises administering to an individual having a fragile ecosystem a nutritional composition comprising at least one amino acid in an amount efficient to favor the growth of bacterial microbiota. 
     
     
         14 . A method for stimulating the immune defenses and/or reduce allergy in humans or pets, which comprises administering to an individual a nutritional composition comprising at least one amino acid in an amount efficient to favor the growth of bacterial microbiota.