US2008274053A1PendingUtilityA1

Tissue metabolic stress monitoring

61
Individually held — no corporate assignee on recordPriority: Oct 17, 2005Filed: Jul 14, 2008Published: Nov 6, 2008
Est. expiryOct 17, 2025(expired)· nominal 20-yr term from priority
Inventors:Pradeep M. GupteRobert L. Delapaz
A61K 49/08A61K 49/1806
61
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Claims

Abstract

Various pathophysiological states are determined by evaluating the rate of 17 O-containing water production oxygen using proton MRI. The method can be used to identify viable but threatened myocardium, injured by viable muscle, penumbra tissue in a stroke patient, and the like.

Claims

exact text as granted — not AI-modified
1 - 14 . (canceled) 
     
     
         15 . A method of identifying abnormalities in tissue of a patient, the method comprising:
 administering  17 O 2  to the patient; and   identifying tissue under oxidative stress, said identifying comprising comparing an oxygen extraction fraction of a first zone in a first tissue zone to the oxygen extraction fraction in a second tissue zone using a proton magnetic resonance imaging system.   
     
     
         16 . The method of  claim 15  wherein the  17 O 2  is dissolved in a liquid carrier and is administered to the patient intravenously. 
     
     
         17 . The method of  claim 15 , wherein the second tissue zone is located in tissue that is ischemic and the first tissue zone is located in tissue that is not ischemic. 
     
     
         18 . The method of  claim 15 , wherein the first tissue zone and the second tissue zone are located in tissue that is ischemic.

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