US2008269487A1PendingUtilityA1

4-anilino quinazoline derivatives as antiproliferative agents

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Assignee: ASTRAZENECA ABPriority: Mar 28, 2002Filed: Jun 26, 2008Published: Oct 30, 2008
Est. expiryMar 28, 2022(expired)· nominal 20-yr term from priority
Inventors:Robert Hugh BradburyLaurent Francois Andre HennequinJason Grant Kettle
A61P 35/02A61P 9/10A61P 35/00A61P 43/00C07D 401/12A61P 13/08C07D 403/12A61P 17/06C07D 401/14
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Claims

Abstract

The invention concerns quinazoline derivatives of Formula (I) wherein each of Q 1 , Z, R 1 and Q 2 have any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an antiproliferative agent in the prevention or treatment of tumours which are sensitive to inhibition of erbB receptor tyrosine kinases.

Claims

exact text as granted — not AI-modified
1 - 22 . (canceled) 
     
     
         23 . 6-{[1-(carbamoylmethyl)piperidin-4-yl]oxy}-4-(3-chloro-2-fluoroanilino)-7-methoxyquinazoline and/or a pharmaceutically acceptable salt thereof.

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